Special Issue "Replication-Competent Reporter-Expressing Viruses"
A special issue of Viruses (ISSN 1999-4915).
Deadline for manuscript submissions: closed (29 February 2016) | Viewed by 118780
A printed edition of this Special Issue is available here.
2. Texas Biomedical Research Institute, San Antonio, TX 78245, USA
Interests: virology; vaccines; antivirals; influenza viruses; arenaviruses; Zika virus; coronavirus; SARS-CoV-2; COVID-19; innate immunity; adaptive immunity; interferon; virus-host interactions
Special Issues, Collections and Topics in MDPI journals
Special Issue in Viruses: New Advances on Zika Virus Research
Special Issue in Vaccines: Feature Papers Collection on Influenza Vaccines
Special Issue in Antibodies: Antibodies, B Cell Responses and Immune Responses to SARS-CoV-2 Infections
Topical Collection in Viruses: Coronaviruses
Topical Collection in Viruses: SARS-CoV-2 and COVID-19
Topical Collection in Pathogens: SARS-CoV-2 Infection and COVID-19 Disease
With the development of reverse genetics systems, recombinant viruses expressing reporter fluorescent or bioluminescent genes represent an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of infection. Expression of reporter proteins allows for direct viral detection in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, fluorescent or bioluminescence tractable replicating-compatible viruses provide an ideal tool to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-through put screening settings. In this Special Issue, we aim to review replicating-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. Contrasting advantages, we also seek to discuss disadvantages associated with these reporter-expressing viruses. Finally, we will provide rational future perspectives and additional avenues for the development, characterization, and application of recombinant, reporter-expressing, competent viruses.
Prof. Dr. Luis Martinez-Sobrido
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- reporter genes
- recombinant viruses
- replicating-competent viruses
- in vivo imaging
- dynamics of viral infections