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Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors

Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma, E-28029 Madrid, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Luis Martinez-Sobrido
Viruses 2016, 8(5), 134;
Received: 18 March 2016 / Revised: 10 May 2016 / Accepted: 12 May 2016 / Published: 21 May 2016
(This article belongs to the Special Issue Replication-Competent Reporter-Expressing Viruses)
PDF [1730 KB, uploaded 21 May 2016]


Vaccinia virus (VACV) is one of the most extensively-studied viruses of the Poxviridae family. It is easy to genetically modify, so it has become a key tool for many applications. In this context, reporter genes facilitate the study of the role of foreign genes introduced into the genome of VACV. In this review, we describe the type of reporter genes that have been used to generate reporter-expressing VACV and the applications of the recombinant viruses obtained. Reporter-expressing VACV are currently employed in basic and immunology research, in the development of vaccines and cancer treatment. View Full-Text
Keywords: vaccinia virus; vaccine; reporter-expressing virus vaccinia virus; vaccine; reporter-expressing virus

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Al Ali, S.; Baldanta, S.; Fernández-Escobar, M.; Guerra, S. Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors. Viruses 2016, 8, 134.

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