Special Issue "Deciphering the Molecular Targets of Prion and Prion-Like Strains"
Deadline for manuscript submissions: closed (31 January 2019).
Interests: neuroscience; neurodegeneration; prion diseases; Alzheimer’s disease; proteinopathies
Prion strains are conformational variants of abnormal prion proteins and can be distinguished by differences in disease incubation times, lesion profiles and electrophoretic mobilities. It has long been postulated that differences in clinical phenotypes may be associated with distinct prion strains, but direct evidence for this hypothesis is missing due to the lack of understanding of molecular disease pathways.
While initially attributed to prion diseases, it is now becoming evident that strains of aggregation-prone proteins are found in other neurodegenerative diseases. Recent data on the strain-properties of α-synuclein, Tau, Aβ, SOD1, and TDP-43 suggests that strains may be a ubiquitous phenomenon of pathogenic protein aggregates. Data on selective neuronal vulnerability and distinct clinical phenotypes in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and tauopathies show compelling analogies with those in prion diseases.
This common interest in prion-like mechanisms across disciplines in dementia research creates opportunities to identify the critical targets and disease pathways of neurodegeneration that may be difficult or impossible to infer from the data available to a single discipline. The critical and most challenging question concerns the mechanistic underpinning of the selective neuronal vulnerability of strains. To address this, the most suitable and advanced models, from tissue cultures to mouse models, have to be implemented to provide translatable data.
This Special Issue is a forum to share and publish data and insights on the strain properties of protein aggregates, including recent data on the molecular targets of strains, biological and/or adaptive responses to strains and suggestions for new concepts to decipher the molecular targets of selective neuronal vulnerability.Dr. Peter Kloehn
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Amyloid beta
- clincial target area
- selective neuronal vulnerability
- prion diseases
- Alzheimer’s disease
- Parkinson’s disease
- amyotrophic lateral sclerosis
- frontotemporal dementia