Special Issue "Expert Views on HPV Infection"
Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 243987
A printed edition of this Special Issue is available here.
Interests: Viral replication mechanisms, HPV, papillomaviruses, persistent infection, keratinocyte biology, host restriction factors, viral chromatin, genetic instability
There are over two hundred different human papillomavirus (HPV) types, which replicate in mucosal and cutaneous stratified epithelial surfaces giving rise to a wide range of persistent lesions. A subset of these viruses are oncogenic and have been demonstrated to be the causative agent of approximately 5% human cancers. Papillomaviruses have a remarkable life style that relies on the differentiation state of the host epithelium; they infect the basal cells of the epithelium and establish a quiescent infection in the proliferative cells. As the infected cells differentiate, the productive life cycle is activated and virions are released from the surface of the epithelium. To support this life style, HPVs interact with, and manipulate, many key cellular pathways and the study of HPV infection has provided insight into many fundamental aspects of human biology. The goal of this Special Issue is to obtain expert viewpoints on unresolved, controversial or emerging topics related to the natural history, evolution, biology, and disease association of HPV infection.
Dr. Alison A. McBride
Dr. Karl Munger
Manuscript Submission Information
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- Human papillomavirus
- Oncogenic virus