Special Issue "Baculovirus Advances and Applications"
Deadline for manuscript submissions: closed (30 September 2018).
Interests: insect virus biology; baculovirus expression systems; baculovirus-host cell interactions at cellular level
It is now more than 30 years since the use of baculoviruses as expression vectors was first described. Since then, many hundreds, if not thousands, of genes have been expressed in insect cells using the baculovirus system. Advances have been made to enable multiple genes to be expressed that can assemble into protein complexes including virus-like particles. High yields of quality proteins including those targeted to membranes or for secretion can be attained. The vectors have also been modified to facilitate gene expression in mammalian and human cells. These developments have enabled the insect expression system to be at the forefront of developments to produce new vaccines for human and animal health, and as a vector for the delivery of genes into human tissue. It is these developments that form the focus of this Special Issue.Prof. Linda King
Prof. Robert Possee
Manuscript Submission Information
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- baculovirus expression vectors
- BacMam vectors
- insect cells
- mammalian cells
- virus-like particles
- gene therapy