Advances in Rabies Research 2023

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1896

Special Issue Editors


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Guest Editor
Former Director at Centro Nacional de Servicios de Diagnóstico en Salud Animal, Senasica, Mexico
Interests: molecular virology; cell culture; immunology of infectious diseases; virus diseases; immunization; diagnostics; emerging infectious diseases; infectious disease control and prevention; vaccines; veterinary diagnostics

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Guest Editor

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Advances in Rabies Research 2023”, continues the series dedicated to research on rabies, following “Special issue on Advances in Rabies Research”, which was specifically focused on the molecular biology of rabies in order to better understand its viral transmission dynamics,  vaccination strategies, and rabies diagnosis (https://www.mdpi.com/journal/viruses/special_issues/advance_rabies).

The aim of this Special Issue is to continue to collect novel contributions in the field of rabies research, providing new insights and addressing research on unresolved issues. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, clinical virology of medical and veterinarian relevance, gene therapy, and novel antiviral strategies are a just selection of topics relevant to research in the field, and can be contributed to this Special Issue.

The Special Issue is associated with the conference “XXXIII Rabies In The Americas“ (RITA) international conference, which will now be taking place in Bogota, Colombia, in October 2023, as an on-site event. RITA is a conference that has been held every year since 1990 by the United States of America, Canada, and Mexico, and more recently by Brazil and Argentina, as well as other Latin American countries; it aims to connect researchers, national and local directors of programs, laboratory workers and all those in the Americas and in other parts of the world who are involved in the surveillance, prevention and control of Rabies. RITA conferences are events strictly centered on all aspects of rabies research and provide excellent opportunities to focus on research topics in this area. Symposium participants, as well as all researchers working in the field, are cordially invited to contribute original research papers or propose reviews to this Special Issue of Viruses. For further information, visit the dedicated website: https://www.rabiesintheamericas.org/.

Dr. Juan A. Montaño-Hirose
Prof. Dr. Charles E. Rupprecht
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

22 pages, 6191 KiB  
Article
Toward the Development of a Pan-Lyssavirus Vaccine
by Sabrine Ben Hamed, Jacob F. Myers, Anisha Chandwani, Christoph Wirblich, Drishya Kurup, Nir Paran and Matthias J. Schnell
Viruses 2024, 16(7), 1107; https://doi.org/10.3390/v16071107 - 10 Jul 2024
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Abstract
In addition to the rabies virus (RABV), 16 more lyssavirus species have been identified worldwide, causing a disease similar to RABV. Non-rabies-related human deaths have been described, but the number of cases is unknown, and the potential of such lyssaviruses causing human disease [...] Read more.
In addition to the rabies virus (RABV), 16 more lyssavirus species have been identified worldwide, causing a disease similar to RABV. Non-rabies-related human deaths have been described, but the number of cases is unknown, and the potential of such lyssaviruses causing human disease is unpredictable. The current rabies vaccine does not protect against divergent lyssaviruses such as Mokola virus (MOKV) or Lagos bat virus (LBV). Thus, a more broad pan-lyssavirus vaccine is needed. Here, we evaluate a novel lyssavirus vaccine with an attenuated RABV vector harboring a chimeric RABV glycoprotein (G) in which the antigenic site I of MOKV replaces the authentic site of rabies virus (RABVG-cAS1). The recombinant vaccine was utilized to immunize mice and analyze the immune response compared to homologous vaccines. Our findings indicate that the vaccine RABVG-cAS1 was immunogenic and induced high antibody titers against both RABVG and MOKVG. Challenge studies with different lyssaviruses showed that replacing a single antigenic site of RABV G with the corresponding site of MOKV G provides a significant improvement over the homologous RABV vaccine and protects against RABV, Irkut virus (IRKV), and MOKV. This strategy of epitope chimerization paves the way towards a pan-lyssavirus vaccine to safely combat the diseases caused by these viruses. Full article
(This article belongs to the Special Issue Advances in Rabies Research 2023)
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