Special Issue "Protoparvoviruses: Friends or Foes?"
Deadline for manuscript submissions: closed (31 January 2018).
Interests: Virology, small DNA Viruses, Virus-Host Cell Interactions, Signaling Cascades, Intracellular Transport, cytoskeleton dynamics, Virotherapy of Cancer, Paroviruses
Over the last few decades, accumulating evidence has demonstrated that some members of the Parvoviridae family, in particular some rodent Protoparvoviruses have natural anticancer activities, while being nonpathogenic to humans. Based on in vitro and pre-clinical studies a first phase I/IIa clinical trial of rat H-1PV was conducted in patients with glioblastoma multiforme. Novel parvovirus-based anticancer strategies with enhanced specificity and efficacy are currently under investigation.
However, a number of Parvoviruses cause diseases in humans and animals. Recently, deep sequencing and metagenomic techniques have allowed the discovery of several novel parvoviruses, suspected of being pathogenic; in particular bufaviruses, which were assigned to the genus Protoparvovirus.
While Protoparvoviruses have a low genetic complexity, many steps of the virus cycle are still not completely understood. This Special Issue of Viruses will explore the impact of Protoparvovirus evolution on the outcome of the interactions of these agents with host cells and organisms. Topics may include studies on various steps of the viral cycle, virus adaptation, immune responses to infection and mechanisms of virus immune evasion, clinical presentation of virus infection, and strategies for vaccine development.
Dr. Christiane Dinsart
Dr. Jürg Nüesch
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Parvovirus-host cell interaction
- Parvovirus adaptation/evolution
- New parvoviral pathogens
- Parvoviral therapeutics and vaccines