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Viruses
Special Issues
Hepatitis E Virus (HEV) 2.0
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Special Issue "Hepatitis E Virus (HEV) 2.0"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3476

Special Issue Editor

Dr. Siddharth Sridhar

E-Mail Website
Guest Editor
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
Interests: viral hepatitis; clinical virology; zoonosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hepatitis E virus (HEV) is one of the most important causes of viral hepatitis globally. HEV is actually an umbrella term for a large group of variants, many of which can cause human infections. Through multiple transmission routes (food-borne zoonotic, human-to-human, blood-borne), HEV has established niches in various epidemiological settings. The clinical spectrum of hepatitis E ranges from asymptomatic infection to fulminant hepatitis. Extrahepatic manifestations are increasingly recognized, and immunocompromised patients are prone to persistent infections.

We are honoured to act as guest editors for this Special Issue entitled ‘Hepatitis E Virus (HEV)’, which seeks to publish high-quality original research and review articles on unanswered questions in the field of hepatitis E pathogenesis, epidemiology, clinical management, and control. Both clinical research and basic research with translational relevance are welcome.

Dr. Siddharth Sridhar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatitis E virus
  • epidemiology
  • clinical diagnostics
  • clinical management
  • animal models
  • antivirals
  • vaccines

Published Papers (2 papers)

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Research

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Article
Clustered Cases of Waterborne Hepatitis E Virus Infection, France
by
Sébastien Lhomme
,
Sébastien Magne
,
Sylvie Perelle
,
Emmanuelle Vaissière
,
Florence Abravanel
,
Laetitia Trelon
,
Catherine Hennechart-Collette
,
Audrey Fraisse
,
Sandra Martin-Latil
,
Jacques Izopet
,
Julie Figoni
and
Guillaume Spaccaferri
Viruses 2023, 15(5), 1149; https://doi.org/10.3390/v15051149 - 11 May 2023
Cited by 2 | Viewed by 1128
Abstract
The identification of seven cases of hepatitis E virus infection in a French rural hamlet in April 2015 led to investigations confirming the clustering and identifying the source of the infection. Laboratories and general practitioners in the area actively searched for other cases [...] Read more.
The identification of seven cases of hepatitis E virus infection in a French rural hamlet in April 2015 led to investigations confirming the clustering and identifying the source of the infection. Laboratories and general practitioners in the area actively searched for other cases based on RT-PCR and serological tests. The environment, including water sources, was also checked for HEV RNA. Phylogenetic analyses were performed to compare HEV sequences. No other cases were found. Six of the seven patients lived in the same hamlet, and the seventh used to visit his family who lived there. All HEV strains were very similar and belonged to the HEV3f subgenotype, confirming the clustering of these cases. All the patients drank water from the public network. A break in the water supply to the hamlet was identified at the time the infection probably occurred; HEV RNA was also detected in a private water source that was connected to the public water network. The water flowing from the taps was quite turbid during the break. The private water supply containing HEV RNA was the likely source of the contamination. Private water supplies not disconnected from the public network are still frequent in rural areas, where they may contribute to public water pollution. Full article
(This article belongs to the Special Issue Hepatitis E Virus (HEV) 2.0)
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Review

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Review
The Re-Emergence of Hepatitis E Virus in Europe and Vaccine Development
by
Gergana Zahmanova
,
Katerina Takova
,
Valeria Tonova
,
Tsvetoslav Koynarski
,
Laura L. Lukov
,
Ivan Minkov
,
Maria Pishmisheva
,
Stanislav Kotsev
,
Ilia Tsachev
,
Magdalena Baymakova
and
Anton P. Andonov
Viruses 2023, 15(7), 1558; https://doi.org/10.3390/v15071558 - 16 Jul 2023
Viewed by 1899
Abstract
Hepatitis E virus (HEV) is one of the leading causes of acute viral hepatitis. Transmission of HEV mainly occurs via the fecal-oral route (ingesting contaminated water or food) or by contact with infected animals and their raw meat products. Some animals, such as [...] Read more.
Hepatitis E virus (HEV) is one of the leading causes of acute viral hepatitis. Transmission of HEV mainly occurs via the fecal-oral route (ingesting contaminated water or food) or by contact with infected animals and their raw meat products. Some animals, such as pigs, wild boars, sheep, goats, rabbits, camels, rats, etc., are natural reservoirs of HEV, which places people in close contact with them at increased risk of HEV disease. Although hepatitis E is a self-limiting infection, it could also lead to severe illness, particularly among pregnant women, or chronic infection in immunocompromised people. A growing number of studies point out that HEV can be classified as a re-emerging virus in developed countries. Preventative efforts are needed to reduce the incidence of acute and chronic hepatitis E in non-endemic and endemic countries. There is a recombinant HEV vaccine, but it is approved for use and commercially available only in China and Pakistan. However, further studies are needed to demonstrate the necessity of applying a preventive vaccine and to create conditions for reducing the spread of HEV. This review emphasizes the hepatitis E virus and its importance for public health in Europe, the methods of virus transmission and treatment, and summarizes the latest studies on HEV vaccine development. Full article
(This article belongs to the Special Issue Hepatitis E Virus (HEV) 2.0)
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