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State-of-the-Art Aquatic Viruses Research in China

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A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 23305

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Prof. Dr. Jinxing Wang

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School of Life Sciences, Shandong University, Qingdao, China
Interests: innate immunity; invertebrates; pattern recognition receptors; immune signal transduction; antimicrobial peptides; trained immunity; shrimp microbiota; anti-viral responses; viral immune evasion

Special Issue Information

Dear Colleagues,

Aquatic viruses include infected viruses in organisms and free-floating viruses in freshwater and marine environments. They are extremely diverse and highly abundant and there are extensive virus-host interactions with eukaryotic organisms, including shellfish, crustaceans and fishes. Aquatic viruses are also involved in aquatic animal diseases, and some pathogenetic viruses cause serious economic losses in the aquaculture industry.

Chinese scientists actively participate in the study of aquatic viruses, especially viruses in aquaculture animals, and numerous important advancements have been achieved in virus identification and characterization, mechanisms of viral pathogenesis, and host-virus interaction, including host immune responses against viruses and viral immune evasion. All these new achievements have provided essential information and knowledge for developing new strategies in viral disease prevention and control in the aquaculture industry. In this special issue, the state-of-the-art on aquatic viruses research in China, we welcome submissions for original research articles and comprehensive reviews including—but not limited to—all the above mentioned areas.

Prof. Dr. Jinxing Wang
Guest Editor

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Keywords

host-virus interaction
anti-viral responses
viral immune evasion
small non-coding RNAs
immune signal transduction
aquatic viruses
viral disease control
immune system
interferons
antiviral effectors

Published Papers (12 papers)

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12 pages, 6320 KiB

Open AccessArticle

Type II Grass Carp Reovirus Rapidly Invades Grass Carp (Ctenopharyngodon idella) via Nostril–Olfactory System–Brain Axis, Gill, and Skin on Head

by Wentao Zhu, Meihua Qiao, Meidi Hu, Xingchen Huo, Yongan Zhang and Jianguo Su

Viruses 2023, 15(7), 1614; https://doi.org/10.3390/v15071614 - 23 Jul 2023

Cited by 1 | Viewed by 1063

Abstract

Type II grass carp reovirus (GCRV-II) with high pathogenicity and infectivity causes severe hemorrhagic disease, which leads to extensive death in the grass carp and black carp aquaculture. However, the early invasion portal remains unclear. In this study, we explored the invasion portal, time, and pathway of GCRV-II by immersion infection in grass carp. Through the detection of the infected grass carp external body surface tissues, most of them could be detected to carry GCRV-II within 45 min except for the skin covered by scales. Further shortening the duration of infection, we proved that GCRV-II rapidly invades through the nostril (especially), gill, and skin on head at only 5 min post-immersion, rather than merely by adhesion. Subsequently, visual localization investigations of GCRV-II were conducted on the nostril, olfactory system (olfactory bulb and olfactory tract), and brain via immunofluorescence microscopy and transmission electron microscopy. We found that few viruses were located in the nostril at 5 min post-immersion infection, while a significantly increased quantity of viruses were distributed in all of the examined tissues at 45 min. Furthermore, the semi-qRT-PCR and Western blotting results of different infection times confirmed that GCRV-II invades grass carp via the nostril–olfactory system–brain axis and then viral replication unfolds. These results revealed the infection mechanism of GCRV-II in terms of the invasion portal, time, and pathway in grass carp. This study aims to understand the invasion mode of GCRV-II in grass carp, thus providing theoretical support for the prevention and control strategies of hemorrhagic disease. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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15 pages, 13100 KiB

Open AccessArticle

Coinfection with Yellow Head Virus Genotype 8 (YHV-8) and Oriental Wenrivirus 1 (OWV1) in Wild Penaeus chinensis from the Yellow Sea

by Jiahao Qin, Fanzeng Meng, Guohao Wang, Yujin Chen, Fan Zhang, Chen Li, Xuan Dong and Jie Huang

Viruses 2023, 15(2), 361; https://doi.org/10.3390/v15020361 - 27 Jan 2023

Cited by 1 | Viewed by 1587

Abstract

At present, there are few studies on the epidemiology of diseases in wild Chinese white shrimp Penaeus chinensis. In order to enrich the epidemiological information of the World Organisation for Animal Health (WOAH)-listed and emerging diseases in wild P. chinensis, we collected a total of 37 wild P. chinensis from the Yellow Sea in the past three years and carried out molecular detection tests for eleven shrimp pathogens. The results showed that infectious hypodermal and hematopoietic necrosis virus (IHHNV), Decapod iridescent virus 1 (DIV1), yellow head virus genotype 8 (YHV-8), and oriental wenrivirus 1 (OWV1) could be detected in collected wild P. chinensis. Among them, the coexistence of IHHNV and DIV1 was confirmed using qPCR, PCR, and sequence analysis with pooled samples. The infection with YHV-8 and OWV1 in shrimp was studied using molecular diagnosis, phylogenetic analysis, and transmission electron microscopy. It is worth highlighting that this study revealed the high prevalence of coinfection with YHV-8 and OWV1 in wild P. chinensis populations and the transmission risk of these viruses between the wild and farmed P. chinensis populations. This study enriches the epidemiological information of WOAH-listed and emerging diseases in wild P. chinensis in the Yellow Sea and raises concerns about biosecurity issues related to wild shrimp resources. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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16 pages, 3632 KiB

Open AccessArticle

A Novel Hemocyte-Specific Small Protein Participates in White Spot Syndrome Virus Infection via Binding to Viral Envelope Protein

by Mingzhe Sun, Shihao Li, Yang Yu, Xiaojun Zhang and Fuhua Li

Viruses 2023, 15(1), 227; https://doi.org/10.3390/v15010227 - 13 Jan 2023

Cited by 3 | Viewed by 1729

Abstract

Hemocytes are essential components of the immune system against invading pathogens in shrimp. Many uncharacterized transcripts exist in hemocytes but the knowledge of them is very limited. In the present study, we identified a novel small protein from the uncharacterized transcripts in hemocytes of Litopenaeus vannamei. This transcript was specifically expressed in hemocytes and encoded a novel secretory protein, which was designated as hemocyte-specific small protein (LvHSSP). The expression level of LvHSSP was significantly up-regulated in the hemocytes of shrimp infected with white spot syndrome virus (WSSV). After knockdown of LvHSSP by RNA interference, the WSSV copy number in shrimp decreased significantly. Conversely, WSSV copy number increased in shrimp when they were infected by WSSV after incubation with recombinant LvHSSP protein. These results suggested that LvHSSP might promote viral infection in shrimp. Immunocytochemical assay showed that the recombinant LvHSSP protein was located on the membrane of hemocytes. Co-IP results showed that LvHSSP could interact with VP26, the main envelope protein of WSSV, suggesting that LvHSSP might mediate WSSV adhesion and entry into host cells by binding to viral envelope protein. Meanwhile, the total hemocyte counts were significantly decreased after LvHSSP knockdown while increased after supplementing with recombinant LvHSSP protein, supporting the idea of hemocytes as the carrier for systemic dissemination of WSSV. This study reported a novel small protein in hemocytes, which modulated the viral infection in shrimp. Our results will enrich the knowledge of invertebrate innate immunity and provide a new field in the study of hemocyte function. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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17 pages, 3320 KiB

Open AccessArticle

The sORF-Encoded Peptides, ATP Synthase Subunits, Facilitate WSSV Duplication in Shrimp

by Li-Jie Huo, Peng-Yuan Lu, Dian-Xiang Li and Xiu-Zhen Shi

Viruses 2022, 14(11), 2449; https://doi.org/10.3390/v14112449 - 04 Nov 2022

Cited by 2 | Viewed by 1348

Abstract

Short open reading frames (sORFs) are a newly identified family of genes, and the functions of most sORF genes and their encoded peptides (SEPs) are still unknown. In this study, two ATP synthase subunits were identified in kuruma shrimp (Marsupenaeus japonicus) as SEPs, namely MjATP5I and MjATP5L. They were widely distributed in all of the tested tissues of shrimp and upregulated in hemocytes and intestines in response to WSSV challenge. The injection of recombinant proteins (rMjATP5I and rMjATP5L) increased the expression of Ie1 and Vp28, while the knockdown of MjATP5I and MjATP5L decreased the expression of Ie1 and Vp28. All of the results suggest that MjATP5I and MjATP5L were beneficial for WSSV replication. Further exploration found that MjATP5I and MjATP5L RNAi significantly improved the shrimp survival rates, reduced ATP production, and upregulated the expression of antimicrobial peptide genes post viral challenge, and the two ATPase subunits and Relish negatively regulated each other. These results reveal that MjATP5I and MjATP5L facilitated WSSV duplication by regulating the production of ATP contents and the expression of antimicrobial peptide genes in shrimp. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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19 pages, 3385 KiB

Open AccessArticle

Lysyl Oxidase-like Protein Recognizes Viral Envelope Proteins and Bacterial Polysaccharides against Pathogen Infection via Induction of Expression of Antimicrobial Peptides

by Peng-Yuan Lu, Guo-Juan Niu, Pan-Pan Hong and Jin-Xing Wang

Viruses 2022, 14(9), 2072; https://doi.org/10.3390/v14092072 - 18 Sep 2022

Cited by 1 | Viewed by 1904

Abstract

Lysyl oxidases (LOXs) are copper-dependent monoamine oxidases, and they play critical roles in extracellular matrix (ECM) remodeling. The LOX and LOX-like (LOXL) proteins also have a variety of biological functions, such as development and growth regulation, tumor suppression, and cellular senescence. However, the functions of LOXLs containing repeated scavenger receptor cysteine-rich (SRCR) domains in immunity are rarely reported. In this study, we characterized the antiviral and antibacterial functions of a lysyl oxidase-like (LOXL) protein containing tandem SRCR domains in Marsupenaeus japonicus. The mRNA level of LoxL was significantly upregulated in the hemocytes and intestines of shrimp challenged using white spot syndrome virus (WSSV) or bacteria. After the knockdown of LoxL via RNA interference, WSSV replication and bacterial loads were apparently increased, and the survival rate of the shrimp decreased significantly, suggesting that LOXL functions against pathogen infection in shrimp. Mechanistically, LOXL interacted with the envelope proteins of WSSV or with lipopolysaccharide and peptidoglycan from bacteria in shrimp challenged using WSSV or bacteria, and it promoted the expression of a battery of antimicrobial peptides (AMPs) via the induction of Dorsal nuclear translocation against viral and bacterial infection. Moreover, LOXL expression was also positively regulated by Dorsal in the shrimp challenged by pathogens. These results indicate that, by acting as a pattern recognition receptor, LOXL plays vital roles in antiviral and antibacterial innate immunity by enhancing the expression of AMPs in shrimp. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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17 pages, 4301 KiB

Open AccessArticle

IHNV Infection Induces Strong Mucosal Immunity and Changes of Microbiota in Trout Intestine

by Zhenyu Huang, Mengting Zhan, Gaofeng Cheng, Ruiqi Lin, Xue Zhai, Haiou Zheng, Qingchao Wang, Yongyao Yu and Zhen Xu

Viruses 2022, 14(8), 1838; https://doi.org/10.3390/v14081838 - 22 Aug 2022

Cited by 12 | Viewed by 2299

Abstract

The fish intestinal mucosa is among the main sites through which environmental microorganisms interact with the host. Therefore, this tissue not only constitutes the first line of defense against pathogenic microorganisms but also plays a crucial role in commensal colonization. The interaction between the mucosal immune system, commensal microbiota, and viral pathogens has been extensively described in the mammalian intestine. However, very few studies have characterized these interactions in early vertebrates such as teleosts. In this study, rainbow trout (Oncorhynchus mykiss) was infected with infectious hematopoietic necrosis virus (IHNV) via a recently developed immersion method to explore the effects of viral infection on gut immunity and microbial community structure. IHNV successfully invaded the gut mucosa of trout, resulting in severe tissue damage, inflammation, and an increase in gut mucus. Moreover, viral infection triggered a strong innate and adaptive immune response in the gut, and RNA−seq analysis indicated that both antiviral and antibacterial immune pathways were induced, suggesting that the viral infection was accompanied by secondary bacterial infection. Furthermore, 16S rRNA sequencing also revealed that IHNV infection induced severe dysbiosis, which was characterized by large increases in the abundance of Bacteroidetes and pathobiont proliferation. Moreover, the fish that survived viral infection exhibited a reversal of tissue damage and inflammation, and their microbiome was restored to its pre−infection state. Our findings thus demonstrated that the relationships between the microbiota and gut immune system are highly sensitive to the physiological changes triggered by viral infection. Therefore, opportunistic bacterial infection must also be considered when developing strategies to control viral infection. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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15 pages, 3623 KiB

Open AccessArticle

A Deacetylase CqSIRT1 Promotes WSSV Infection by Binding to Viral Envelope Proteins in Cherax quadricarinatus

by Shucheng Zheng, Fanjuan Meng, Dongli Li, Lingke Liu, Di Ge, Qing Wang and Haipeng Liu

Viruses 2022, 14(8), 1733; https://doi.org/10.3390/v14081733 - 06 Aug 2022

Viewed by 1810

Abstract

Sirtuin 1 (SIRT1), a member of the class III lysine deacetylases, exhibits powerful functional diversity in physiological processes and disease occurrences. However, the potential molecular mechanism underlying the role of SIRT1 during viral infection in crustaceans is poorly understood. Herein, SIRT1 was functionally characterized from the red claw crayfish Cherax quadricarinatus, which possesses typically conserved deacetylase domains and strong evolutionary relationships across various species. Moreover, gene knockdown of CqSIRT1 in crayfish haematopoietic tissue (Hpt) cell culture inhibited white spot syndrome virus (WSSV) late envelope gene vp28 transcription. In contrast, enhancement of deacetylase activity using a pharmacological activator promoted the replication of WSSV. Mechanically, CqSIRT1 was co-localized with viral envelope protein VP28 in the nuclei of Hpt cells and directly bound to VP28 with protein pulldown and co-immunoprecipitation assays. Furthermore, CqSIRT1 also interacted with another two viral envelope proteins, VP24 and VP26. To the best of our knowledge, this is the first report that WSSV structural proteins are linked to lysine deacetylases, providing a better understanding of the role of CqSIRT1 during WSSV infection and novel insights into the basic mechanism underlying the function of lysine deacetylases in crustaceans. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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16 pages, 3142 KiB

Open AccessArticle

Long Noncoding RNA MIR122HG Inhibits MAVS-Mediated Antiviral Immune Response by Deriving miR-122 in Miiuy Croaker (Miichthys miiuy)

by Junxia Cui, Weiwei Zheng, Tianjun Xu and Yuena Sun

Viruses 2022, 14(5), 930; https://doi.org/10.3390/v14050930 - 29 Apr 2022

Cited by 5 | Viewed by 1714

Abstract

Long noncoding RNAs (lncRNAs) function as micro regulators to impact gene expression after multiple pathogen infections, which have been largely studied in the last few years. Although lncRNA studies on lower vertebrates have received less attention than those on mammals, current studies suggest that lncRNA plays an important role in the immune response of fish to pathogen infections. Here, we studied the effect of MIR122HG as the host gene of miR-122 and indirectly negatively regulate MAVS-mediated antiviral immune responses in miiuy croaker (Miichthysmiiuy). We found that poly(I:C) significantly increases the host MIR122HG expression. The increased MIR122HG expression inhibited the production of the antiviral immune-related genes IFN-1, ISG15 and Viperin upon SCRV treatment. In addition, MIR122HG can act as a pivotally negative regulator involved in the MAVS-mediated NF-κB and IRF3 signaling pathways, which can effectively avoid an excessive immune response. Additionally, we found that MIR122HG can promote the replication of SCRV. Our study provides evidence about the involvement of lncRNAs in the antiviral immune response of fish and broadens the understanding of the function of lncRNAs as a precursor miRNA in teleost fish. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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15 pages, 6029 KiB

Open AccessArticle

ADRV 12L: A Ranaviral Putative Rad2 Family Protein Involved in DNA Recombination and Repair

by Fei Ke and Qi-Ya Zhang

Viruses 2022, 14(5), 908; https://doi.org/10.3390/v14050908 - 27 Apr 2022

Cited by 4 | Viewed by 1529

Abstract

The Andrias davidianus ranavirus (ADRV) is a member of the family Iridoviridae and belongs to the nucleocytoplasmic large DNA viruses. Based on genomic analysis, an ADRV-encoding protein, ADRV 12L, and its homologs from other iridoviruses were predicted as Rad2 family proteins based on the conserved amino acids, domains, and secondary structures. Expression analysis showed that the transcription of ADRV 12L started at 4 h post infection, and its expression was not inhibited by a DNA-replication inhibitor. Meanwhile, immunofluorescence localization showed that ADRV 12L mainly localized in viral factories and colocalized with the viral nascent DNA, which hinted at a possible role in DNA replication. Furthermore, a mutant ADRV lacking 12L (ADRV-Δ12L) was constructed. In both luciferase assays based on homologous recombination (HR) and double-strand break repair (DSBR) that followed, ADRV-Δ12L induced less luciferase activity than the wild-type ADRV, indicating that HR and DSBR were impaired in ADRV-Δ12L infected cells. In addition, infection with ADRV-Δ12L resulted in smaller plaque sizes and lower viral titers than that with wild-type ADRV, indicating an important role for 12L in efficient virus infection. Therefore, the results suggest that Rad2 homologs encoded by iridovirus have important roles in HR- and DSBR-process of the viral DNA and, thus, affect virus replication and the production of progeny virions. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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13 pages, 3926 KiB

Open AccessArticle

Characterization of Host Cell Potential Proteins Interacting with OsHV-1 Membrane Proteins

by Jiangnan Yu, Ying Liu, Bowen Huang, Chen Li, Dandan Wang, Mengli Yao, Lusheng Xin, Changming Bai and Chongming Wang

Viruses 2021, 13(12), 2518; https://doi.org/10.3390/v13122518 - 15 Dec 2021

Cited by 2 | Viewed by 2079

Abstract

The interaction between viral membrane associate proteins and host cellular surface molecules should facilitate the attachment and entry of OsHV-1 into host cells. Thus, blocking the putative membrane proteins ORF25 and ORF72 of OsHV-1 with antibodies that have previously been reported to subdue OsHV-1 replication in host cells, especially ORF25. In this study, prey proteins in host hemocytes were screened by pull-down assay with recombinant baits ORF25 and ORF72, respectively. Gene Ontology (GO) analysis of these prey proteins revealed that most of them were mainly associated with binding, structural molecule activity and transport activity in the molecular function category. The protein–protein interaction (PPI) network of the prey proteins was constructed by STRING and clustered via K-means. For both ORF25 and ORF72, three clusters of these prey proteins were distinguished that were mainly associated with cytoskeleton assembly, energy metabolism and nucleic acid processing. ORF25 tended to function in synergy with actins, while ORF72 functioned mainly with tubulins. The above results suggest that these two putative membrane proteins, ORF25 and ORF72, might serve a role in the transport of viral particles with the aid of a cytoskeleton inside cells. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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14 pages, 2545 KiB

Open AccessArticle

Characterization of Ictalurid herpesvirus 1 Glycoprotein ORF59 and Its Potential Role on Virus Entry into the Host Cells

by Shu-Xin Li, Fei Yu, Hong-Xun Chen, Xiao-Dong Zhang, Li-Hui Meng, Kai Hao and Zhe Zhao

Viruses 2021, 13(12), 2393; https://doi.org/10.3390/v13122393 - 29 Nov 2021

Cited by 6 | Viewed by 2132

Abstract

The channel catfish virus (CCV, Ictalurid herpesvirus 1) has caused sustained economic losses in the fish industry because of its strong infectivity and pathogenicity. Thus, it is necessary to determine the function of viral proteins in the CCV infection process. The present study aimed to characterize CCV glycoprotein ORF59 and explore its impact on virus infection in host cells. Firstly, its exclusive presence in the membrane fraction of the cell lysate and subcellular localization verified that CCV ORF59 is a viral membrane protein expressed at late-stage infection. A protein blocking assay using purified His6 tagged ORF59, expressed in sf9 insect cells using a baculovirus expression system, indicated a dose-dependent inhibitory effect of recombinant ORF59 protein on virus invasion. Knockdown of the ORF59 using a short hairpin (shRNA) showed that ORF59 silencing decreased the production of infectious virus particles in channel catfish ovary cells. The results of this study suggest that recombinant ORF59 protein might inhibit CCV entry into the host cells. These findings will promote future studies of the key functions of glycoprotein ORF59 during CCV infection. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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Review

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18 pages, 366 KiB

Open AccessReview

Role of Cellular Receptors in the Innate Immune System of Crustaceans in Response to White Spot Syndrome Virus

by Ngoc Tuan Tran, Huifen Liang, Ming Zhang, Md. Akibul Hasan Bakky, Yueling Zhang and Shengkang Li

Viruses 2022, 14(4), 743; https://doi.org/10.3390/v14040743 - 01 Apr 2022

Cited by 20 | Viewed by 2947

Abstract

Innate immunity is the only defense system for resistance against infections in crustaceans. In crustaceans, white spot diseases caused by white spot syndrome virus (WSSV) are a serious viral disease with high accumulative mortality after infection. Attachment and entry into cells have been known to be two initial and important steps in viral infection. However, systematic information about the mechanisms related to WSSV infection in crustaceans is still limited. Previous studies have reported that cellular receptors are important in the innate immune system and are responsible for the recognition of foreign microorganisms and in the stimulation of the immune responses during infections. In this review, we summarize the current understanding of the functions of cellular receptors, including Toll, C-type lectin, scavenger receptor, β-integrin, polymeric immunoglobulin receptor, laminin receptor, globular C1q receptor, lipopolysaccharide-and β-1,3-glucan-binding protein, chitin-binding protein, Ras-associated binding, and Down syndrome cell adhesion molecule in the innate immune defense of crustaceans, especially shrimp and crabs, in response to WSSV infection. The results of this study provide information on the interaction between viruses and hosts during infections, which is important in the development of preventative strategies and antiviral targets in cultured aquatic animals. Full article

(This article belongs to the Special Issue State-of-the-Art Aquatic Viruses Research in China)

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