Advances in Understanding Spontaneously Occurring Melanoma in Animals
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 55171
Interests: oncology; cancer; metastasis; cancer genetics; cancer genomics; comparative oncology; comparative genomics; animal models of cancer
Special Issues, Collections and Topics in MDPI journals
Interests: veterinary clinical soft tissue surgery; veterinary surgical education; veterinary infection control; naturally occuring canine oral melanoma
Melanoma is a tumour that arises from the uncontrolled proliferation of melanocytes (pigment‐producing cells), found in the skin (cutaneous melanoma), in the mucosal surfaces (mucosal melanoma), the eye (ocular melanoma), and leptomeninges (leptomeningeal melanoma). Although all these subtypes are derived from melanocytes, the aetiology, pathogenesis, genetic landscape and biological behaviour of each are very different.
There are numerous case reports of animals that spontaneously develop melanoma, ranging from fish and snakes to birds and mammals. There has also been significant research into the commonly occurring forms of melanoma that affect dogs (canine oral melanoma) and cats (feline ocular melanoma).
This issue aims to look at the advances that have been made in terms of understanding melanoma in animals—the genetic and epigenetic landscape of the tumour, antigen expression by the tumour, intratumoral immune composition, mechanisms of resistance? Has this translated to new treatment options/regimes, the identification of prognostic indicators or biomarkers, and improved survival outcomes? Do we have any new tools to help us understand melanoma?
This issue aims to publish original research works, reviews or case reports that explore our understanding of spontaneous melanoma in animals.
Dr. Louise van der Weyden
Dr. Kelly Lisa Bowlt Blacklock
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- immune composition
- prognostic markers