Comparative Studies on HIV and FIV in Animals and Humans

Dear Colleagues,

Animal models are essential components of efforts devoted to the development of treatments for diseases and injury for both human and veterinary medicine. This is clearly demonstrated for feline immunodeficiency virus (FIV), where research has not only led to the development of a vaccine effective against heterologous virus challenge, but also has provided a wealth of information on retroviral biology, immunology and neuro-immune interactions relevant to humans infected with human immunodeficiency virus (HIV). The success of efforts focused on the development of interventions for human diseases depends not only on the unique information provided by animal models but also on successful translation of findings from animal studies to humans. The melding of veterinary and human medicine is essential to the process but often receives too little attention leading to costly, inefficient and often-ineffective development strategies. In this Special Issue, “Comparative Studies on HIV and FIV in Animals and Humans”, original articles and short communications will highlight cutting-edge lentiviral research focusing on translational applications. As a complement to original research, several mini-reviews discussing contributions and limitations of the FIV model to our understanding of retroviral pathogenesis will be included. We are excited about this opportunity to present recent advances using this important translational model.

Rick Meeker, PhD
Jonathan Fogle, DVM, PhD, DACVIM
Guest Editors

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