Analysing Canine and Feline Sepsis

Dear Colleagues,

Recently sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis involves organ dysfunction, indicating a pathobiology more complex than infection plus an accompanying inflammatory response alone. Severity of organ dysfunction has been associated with various scoring system, according to clinical findings, laboratory data, and therapeutic interventions. The predominant score in current use is the Sequential Organ Failure Assessment (SOFA). Clinical Criteria of sepsis have been summarized: suspected or documented infection and an acute increase ≥ 2 SOFA score.

Sepsis and MODS have previously been reported in dogs with sepsis of gastrointestinal origin and was associated with increased risk of death.

Recently, the clinical characteristics, outcome, and clinical importance of MODS in dogs with urogenital infections has been evaluated. However, specific risk factors for development urosepsis have not been described.

Finally, the role of viral infections on development of sepsis in dogs and cats have not completely investigated. Parvoviral infection is a predisposing factor for sepsis in dogs, but the role of co-infections and the emerging viruses in the development of sepsis is not completely understood.

This Special Issue aims to publish original research work, reviews or case reports that provide readers with an update on the most recent advances in infections disease predisposing sepsis in dogs and cats.

Examples of manuscript topics that will be considered are:

• New insights into pathogenesis and risk factors
• New insights into clinical criteria and prognostic factors
• Advances in diagnostic tests (eg. molecular test), and imaging
• Novel treatment strategies
• Comparative aspects of sepsis condition in the context of “One Health”

In this Special Issue, original research articles, reviews, and case reports are welcome. All researchers working in the field are cordially invited to contribute relevant articles on this topic.

We look forward to receiving your contributions.

Dr. Giovanni Aste
Dr. Sara Canal
Prof. Dr. Barbara Di Martino
Dr. Roberto Tamburro
Guest Editors

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• sepsis
• urogenital infections
• surgical site infections
• gastrointestinal infections
• neuro-infections
• CNS complications
• SOFA
• qSOFA
• APPLE fast
• bacteriuria
• bacterial culture
• blood culture
• diagnostic
• molecular sequencing
• viruses
• systemic infection