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Veterinary Sciences
Special Issues
Genetic Diversity, Conservation, and Innovative Breeding in Pigs—2nd Edition
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Genetic Diversity, Conservation, and Innovative Breeding in Pigs—2nd Edition

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Biomedical Sciences".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1379

Special Issue Editors

Dr. Ligang Wang

E-Mail Website
Guest Editor
Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Interests: pig; disease resistance; diversity; breeding
Special Issues, Collections and Topics in MDPI journals
Dr. Hongbo Chen

E-Mail Website
Guest Editor
School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Interests: livestock genetics and breeding; animal genomics; genome selection; animal disease resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Genetic diversity represents the heritable variation within and between populations, which is usually associated with economic traits such as disease resistance, growth rates, size, and meat quality characteristics. Thus, the conservation of genetic diversity is essential to present and future breeding.

Therefore, we are pleased to invite you to submit original research concerning the field of pig genetics, investigating the heritability and/or genomic regions associated with pathologies, the exterior, growth, or other traits of interest (coat colors, morphological traits, breed specialization, etc.). The evaluation of genetic diversity in populations, either local or internationally diffused, and the study of domestication, breed development, and history are also topics of interest. In addition, genetic investigations into the relationship between disease and growth are encouraged.

With this Special Issue, we aim to increase the knowledge around the genetic mechanisms underlying disease resistance and traits of interest, thus contributing to pig welfare. Moreover, studying the history and genetic diversity of breeds and populations could aid in their management and conservation. For this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.

Dr. Ligang Wang
Dr. Hongbo Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pig
  • disease resistance
  • pathogenesis and mechanisms of diseases
  • biomedical engineering
  • genetic diversity
  • pig breeding
  • morphological traits
  • breed specialization

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Related Special Issue

Published Papers (2 papers)

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Research

10 pages, 588 KiB  
Article
Genome-Wide Association Study of Gluteus Medius Muscle Size in a Crossbred Pig Population
by Yu He, Chunyan Bai, Junwen Fei, Juan Ke, Changyi Chen, Xiaoran Zhang, Wuyang Liu, Jing Li, Shuang Liang, Boxing Sun and Hao Sun
Vet. Sci. 2025, 12(8), 730; https://doi.org/10.3390/vetsci12080730 (registering DOI) - 3 Aug 2025
Abstract
The size of the gluteus medius muscle (GM) in swine significantly impacts both hindlimb conformation and carcass yield, while little is known about the genetic architecture of this trait. This study aims to estimate genetic parameters and identify candidate genes associated with this [...] Read more.
The size of the gluteus medius muscle (GM) in swine significantly impacts both hindlimb conformation and carcass yield, while little is known about the genetic architecture of this trait. This study aims to estimate genetic parameters and identify candidate genes associated with this trait through a genome-wide association study (GWAS). A total of 439 commercial crossbred pigs, possessing both Landrace and Yorkshire ancestry, were genotyped using the Porcine 50K chip. The length and width of the GM were directly measured, and the area was then calculated from these values. The heritabilities were estimated by HIBLUP (V1.5.0) software, and the GWAS was conducted employing the BLINK model implemented in GAPIT3. The heritability estimates for the length, width, and area of the GM were 0.43, 0.40, and 0.46, respectively. The GWAS identified four genome-wide significant SNPs (rs81381267, rs697734475, rs81298447, and rs81458910) associated with the gluteus medius muscle area. The PDE4D gene was identified as a promising candidate gene potentially involved in the regulation of gluteus medius muscle development. Our analysis revealed moderate heritability estimates for gluteus medius muscle size traits. These findings enhance our understanding of the genetic architecture underlying porcine muscle development. Full article
(This article belongs to the Special Issue Genetic Diversity, Conservation, and Innovative Breeding in Pigs—2nd Edition)
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20 pages, 1236 KiB  
Article
Validation of Polymorphisms Associated with the Immune Response After Vaccination Against Porcine Reproductive and Respiratory Syndrome Virus in Yorkshire Gilts
by Salvador Icedo-Nuñez, Rosa I. Luna-Ramirez, R. Mark Enns, Scott E. Speidel, Jesús Hernández, Xi Zeng, Miguel A. Sánchez-Castro, Carlos M. Aguilar-Trejo, Guillermo Luna-Nevárez, Martha C. López-González, Javier R. Reyna-Granados and Pablo Luna-Nevárez
Vet. Sci. 2025, 12(4), 295; https://doi.org/10.3390/vetsci12040295 - 22 Mar 2025
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Abstract
Porcine respiratory and reproductive syndrome is a viral disease that impacts the health and profitability of swine farms, largely due to significant variation in the vaccination response. The objective was to identify and validate molecular markers associated with the antibody response in gilts [...] Read more.
Porcine respiratory and reproductive syndrome is a viral disease that impacts the health and profitability of swine farms, largely due to significant variation in the vaccination response. The objective was to identify and validate molecular markers associated with the antibody response in gilts following vaccination against the PRRSV. The study included one hundred (n = 100) 6-month-old Yorkshire gilts that were negative for the PRRSV. Gilts were randomly assigned to one of two treatments, PRRS-vaccinated (n = 75) and control (n = 25) groups. Blood samples collected on day 21 were analyzed to evaluate the antibody response, as indicated by the sample-to-positive (S/P) ratio, to the PRRSV following vaccination. DNA was extracted and genotyped using a low-density chip containing 10,000 single nucleotide polymorphisms (SNPs). A genome-wide association study (GWAS) was conducted to identify candidate SNPs associated with the S/P ratio, which were validated in two independent gilt populations (n = 226). The SNPs rs707264998, rs708860811, and rs81358818 in the genes RNF144B, XKR9, and BMAL1, respectively, were significantly associated (p < 0.01) with the S/P ratio and demonstrated an additive effect. In conclusion, three SNPs are proposed as candidate markers for an enhanced immune response to vaccination against the PRRSV and may be beneficial in genetic selection programs. Full article
(This article belongs to the Special Issue Genetic Diversity, Conservation, and Innovative Breeding in Pigs—2nd Edition)
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