Veterinary Sciences

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Special Issue Editors

Dr. Christof Albert Bertram

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Guest Editor

Institute of Pathology, University of Veterinary Medicine Vienna, Vienna, Austria
Interests: tumor pathology (standardization and prognostication); digital pathology; automated image analysis

Dr. Taryn Donovan

E-Mail Website
Guest Editor

Schwarzman Animal Medical Center, New York, NY, USA
Interests: tumor pathology (standardization and prognostication); neuropathology; cardiac pathology

Special Issue Information

Dear Colleagues,

Cytology, histology and immunohistochemistry are the foundation of tumor diagnosis and prognosis. While molecular and genetic tests of tumors and patients are of increasing research interest, microscopic examination by pathologists is likely to remain a fundamental step in the diagnostic workflow due to its practicality and low cost. Microscopic examination is indispensable for clinicians, oncologists and surgeons when making clinical decisions for tumor patients. Despite the high diagnostic and prognostic value of tumor microscopy, many tests within this area have marked observer variability due to their subjective nature and insufficiently described methods. This Special Issue focuses on the diagnosis and prognosis of animal tumors using microscopic methods to improve routine pathologist evaluation.

Topics of interest include, but are not limited to: standardization and validation of prognostic markers and diagnostic criteria; evaluation of new prognostic markers or diagnostic criteria; evaluation of new methods such as digital microscopy and automated image analysis.

This Special Issue aims to publish original research, systematic reviews, reviews, commentaries and consensus statements/guidelines on microscopic tumor evaluation. We look forward to receiving your submissions.

Dr. Christof Albert Bertram
Dr. Taryn Donovan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

artificial intelligence
biomarkers
cytology
diagnosis
guideline
histology
immunohistochemistry
prognosis
standardization
tumor
validation

Published Papers (2 papers)

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Research

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13 pages, 5064 KiB

Open AccessArticle

Analysis of the Prevalence of Canine Splenic Mass Lesions in Republic of Korea via Histopathological Diagnosis with Immunohistochemistry

by Yeong-Ung Ko, Min-Kyung Bae, Jung-Hyang Sur and Nong-Hoon Choe

Vet. Sci. 2023, 10(4), 247; https://doi.org/10.3390/vetsci10040247 - 25 Mar 2023

Cited by 1 | Viewed by 3463

Abstract

The histopathological diagnosis of canine splenic mass lesions is crucial for prognostication. However, thus far, no study has been conducted on the histopathology of canine splenic mass lesions in Republic of Korea. Herein, the prevalence of splenic diseases was analyzed in 137 canine splenic mass lesions via histopathological diagnosis, and the microscopic pattern associated with each disorder was described. Immunohistochemistry was performed for CD31, CD3, PAX5, Iba1, and C-kit for a more accurate diagnosis of splenic tumors. The proportion of non-neoplastic disorders, including nodular hyperplasia (48.2%, n = 66) and hematoma (24.1%, n = 33), was 72.3%. Splenic tumors, including splenic hemangiosarcoma (10.2%, n = 14), splenic lymphoma (nodular and diffuse types, 8.0%, n = 11), splenic stromal sarcoma (7.3%, n = 10), myelolipoma (1.5%, n = 2), and mast cell tumors (0.7%, n = 1), accounted for 27.7% of cases. The results of this study will aid veterinary clinicians in communication with pet owners about prognoses, recommendations for splenectomy, and subsequent histopathological diagnoses. This study will facilitate further investigations with more detailed comparisons of splenic mass lesions between small- and large-breed dogs. Full article

(This article belongs to the Special Issue Veterinary Oncologic Diagnostic and Prognostic Microscopy: Old and New Methods)

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Other

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12 pages, 2032 KiB

Open AccessCase Report

Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma

by Ka-To Chu, Omid Nekouei and Jeanine Rhoda Sandy

Vet. Sci. 2023, 10(3), 190; https://doi.org/10.3390/vetsci10030190 - 2 Mar 2023

Cited by 2 | Viewed by 2601

Abstract

Canine hemangiosarcoma is a common, highly fatal tumor of older dogs, and predictors of survivability may provide clinically useful information. The objectives of this case series were to determine if a previously published tumor histological grading scheme, the level of tumor cellular atypia, clinical staging, or the level of CD 31 expression were useful for predicting the survival time in dogs with splenic hemangiosarcoma. Canine splenic hemangiosarcomas from 16 dogs were histologically graded, clinically staged, and assessed for CD 31 expression. Medical records were reviewed, the date of death was obtained, and survival data were analyzed statistically. Histopathological grading and clinical staging of canine splenic hemangiosarcomas, and the expression of CD 31 by the tumor cells were not significantly associated with the median survival time of the dogs in this study. However, strong expression of CD 31 by canine splenic hemangiosarcoma tumor cells was observed in dogs with short survival times, which warrants further studies to evaluate the potential prognostic value of CD 31 expression for the survival of dogs with splenic hemangiosarcoma. Full article

(This article belongs to the Special Issue Veterinary Oncologic Diagnostic and Prognostic Microscopy: Old and New Methods)

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