Comparative Oncology of Companion Animals

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 30 October 2025 | Viewed by 1053

Special Issue Editors

1. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
2. Comprehensive Health Research Center (CHRC), University of Évora, 7004-516 Évora, Portugal
3. Department of Zootechnics, School of Sciences and Technology, University of Évora, 7004-516 Évora, Portugal
Interests: veterinary medicine; experimental animal models; lifestyle; tumor angiogenesis; natural compounds; animal welfare
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Guest Editor
1. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
2. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
Interests: animal models; in vivo studies; natural compounds
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Post-Graduate Programme in Adult Health (PPGSAD), Federal University of Maranhão, São Luís 65085-580, Brazil
2. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
Interests: cancer cachexia; animal models of cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is among the most common causes of death in companion animals. Companion animals with naturally occurring cancers are widely utilized as a natural model for cancer research. Dogs and cats develop multiple types of cancer with numerous clinical, molecular, histopathological, and genetic similarities to human cancers.

Cancer constitutes a significant clinical challenge in veterinary medicine, with a high prevalence among companion animals. Despite the availability of numerous treatment approaches for cancer, advancements in the understanding of cancer mechanisms and the development of innovative treatments would offer the prospect of improved outcomes for oncologic patients. It is therefore necessary to find new methods for earlier diagnosis and more effective treatment of this disease. The following Special Issue, entitled “Comparative Oncology of Companion Animals”, aims to publish original research works and reviews concerning the diagnosis, treatment, and prognosis of cancer in companion animals, highlighting new advances in this field.

Dr. Ana Faustino
Prof. Dr. Paula Oliveira
Dr. Rui Gil da Costa
Guest Editors

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Keywords

  • cancer
  • companion animals
  • diagnosis
  • prognosis
  • treatment

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Published Papers (1 paper)

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Research

18 pages, 2849 KiB  
Article
Effects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically Induced Rat Model
by Jessica Silva, Tiago Azevedo, Inês Aires, Catarina Medeiros, Maria J. Neuparth, Fernanda Seixas, Rita Ferreira, Ana I. Faustino-Rocha, Paula A. Oliveira and José Alberto Duarte
Vet. Sci. 2025, 12(4), 303; https://doi.org/10.3390/vetsci12040303 - 26 Mar 2025
Viewed by 735
Abstract
Breast cancer remains a significant global health issue, affecting both humans and companion animals, particularly female dogs and cats, where mammary tumors are among the most common cancers. Strategies to minimize the impact of this disease on patients, pet owners, and veterinary medicine [...] Read more.
Breast cancer remains a significant global health issue, affecting both humans and companion animals, particularly female dogs and cats, where mammary tumors are among the most common cancers. Strategies to minimize the impact of this disease on patients, pet owners, and veterinary medicine are essential. This study analyses the effects of resistance training on the development of chemically induced mammary cancer in female Wistar rats, divided into four groups: sedentary control (CTR), sedentary induced (CTR+N-methyl-N-nitrosourea (MNU)), exercised control (EX), and exercised induced (EX+MNU). The exercise protocol involved ladder climbing three times a week for 18 weeks with the load progressively increasing. At the study’s end, blood and histopathological samples were collected and analyzed. Although tumor onset occurred two weeks earlier and incidence was slightly higher in the exercised group (EX+MNU) compared to the control group (CTR+MNU), the mortality rate was lower, and the malignancy was not as aggressive. No systemic inflammation was observed, as the levels of albumin, C-reactive protein (CRP), and interleukin 6 (IL-6) in the MNU groups remained similar to the controls. Exercise has been shown to promote overall health by increasing physical fitness, boosting immunological function, and improving metabolic health. These findings may offer valuable insights into the potential role of resistance training in managing mammary cancer in companion animals. However, further research is required to assess clinical applicability and to establish safe and effective exercise protocols for veterinary oncology. Full article
(This article belongs to the Special Issue Comparative Oncology of Companion Animals)
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