Special Issue "Toxic Effect of Mycotoxins"
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".
Deadline for manuscript submissions: 30 November 2021.
Special Issue Editor
Interests: mycotoxins; proteomics; integrative biology; intestinal pathophysiology; animal sciences
Special Issue Information
Dear Colleagues,
Understanding the individual toxicity of regulated and emerging toxins is essential to establishing their associated risk and contribution to disease pathogenesis. In this sense, the use and integration of global technical approaches, such as -omics approaches, is particularly useful for investigating the adverse outcome pathways and toxicity of mycotoxins with very little a priori information, as well as identifying specific toxic endpoints of “biomarkers of effect”. The latter is especially useful when investigating the toxic interaction of mycotoxins. Indeed, the simultaneous presence of different mycotoxins is potentially able to produce synergistic toxic effects that cannot be predicted from the toxicity of individual mycotoxins. Interaction studies using known and/or new toxicity endpoints are largely needed for multiexposure risk assessment.
Recent studies have associated the toxicity of regulated mycotoxins and the development and/or aggravation of known diseases, particularly when associated with other factors such as stress or obesity as well as other pathogens or toxicants. Likewise, it is becoming evident that several mycotoxins have insidious toxic effects under sub-acute and chronic exposure conditions. However, the exact mechanisms leading to such effects are poorly understood.
Recent advances in the characterization of the metabolome of mycotoxigenic fungal species are providing lists of newly discovered molecules. It is important to associate these discoveries with the development and validation of high-throughput toxicity screening assays to identify new emerging mycotoxins.
We look forward to receiving your contributions for this Special Issue in the form of original research or review papers aiming at advancing the knowledge of the toxicity of any mycotoxin(s) in any species, alone or in combination. Original research articles or reviews on toxicity screening methodology development, including biomarkers of effect, are also welcome.
Dr. Laura Soler-Vasco
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mycotoxins
- risk assessment
- mycotoxin interaction
- proteomics
- transcriptomics
- metabolomics
- biomarker of effect
- toxicity screening
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Research on the metabolic disruption induced by the natural endocrine disruptor zearalenone
Abstract: Zearalenone (ZEN) is a mycoestrogen classified as an endocrine disruptor. Many endocrine disruptors, notably estrogenic agents (i.e. phthalates, polychlorinated bisphenols) are also metabolic disruptors. Although some data available suggest that ZEN can have an impact on metabolism (i.e. the derivative of ZEN Zeranol is employed as an anabolic growth promoter), the role of ZEN as a metabolic disruptor is relatively unexplored. Metabolic disruption is related with changes in energy balance and the regulation of inflammatory processes. A family of protein hormones known as adipokines controls these functions. Signaling pathways known to be altered by ZEN regulate the expression of several adipokines, but the influence of ZEN exposure in the circulating levels of adipokines has not been explored to date. The objective of the study is to evaluate the role of ZEN as a metabolic disruptor in pigs, thus investigating the changes in energy balance and adipokines levels upon exposure to ZEN. Results indicate that exposure to different concentrations to ZEN has a major, non-monotonic impact in lipid and glucose metabolism. In agreement with these changes, ZEN altered adipokine profiles were altered in agreement with these changes, showing significant changes in adiponectin, resistin, and fetuin B thus confirming that ZEN functions as a metabolic disruptor.