Next Article in Journal
An Updated Review of Bioactive Peptides from Mushrooms in a Well-Defined Molecular Weight Range
Next Article in Special Issue
Citrinin Mycotoxin Contamination in Food and Feed: Impact on Agriculture, Human Health, and Detection and Management Strategies
Previous Article in Journal
Cloning and Characterization of Three Novel Enzymes Responsible for the Detoxification of Zearalenone
Previous Article in Special Issue
Ecotoxicological Effects of Aflatoxins on Earthworms under Different Temperature and Moisture Conditions
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Toxins
Volume 14
Issue 2
10.3390/toxins14020083
toxins-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Tissular Genomic Responses to Oral FB1 Exposure in Pigs

by
Léonie Dopavogui
,
Arnaud Polizzi
,
Anne Fougerat
,
Pascal Gourbeyre
,
Chloé Terciolo
,
Wendy Klement
,
Philippe Pinton
,
Joëlle Laffite
,
Anne-Marie Cossalter
,
Jean-Denis Bailly
,
Olivier Puel
,
Yannick Lippi
,
Claire Naylies
,
Hervé Guillou
,
Isabelle P. Oswald
* and
Nicolas Loiseau
*
Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, 31300 Toulouse, France
*
Authors to whom correspondence should be addressed.
Toxins 2022, 14(2), 83; https://doi.org/10.3390/toxins14020083
Submission received: 14 December 2021 / Revised: 12 January 2022 / Accepted: 18 January 2022 / Published: 22 January 2022
(This article belongs to the Special Issue Toxic Effect of Mycotoxins)
Browse Figures
Versions Notes

Abstract

Fumonisin B1 (FB1) is a widespread mycotoxin produced by fungal Fusarium species—mainly in maize, one of the plants most commonly used for food and feed. Pigs and horses are the animal species most susceptible to this mycotoxin. FB1 exposure can cause highly diverse clinical symptoms, including hepatotoxicity, immunotoxicity, and intestinal barrier function disturbance. Inhibition of ceramide synthetase is a well-understood ubiquitous molecular mechanism of FB1 toxicity, but other more tissue-specific effects remain to be elucidated. To investigate the effects of FB1 in different exposed tissues, we cross-analyzed the transcriptomes of fours organs: liver, jejunum, jejunal Peyer’s patches, and spleen. During a four-week study period, pigs were fed a control diet or a FB1-contaminated diet (10 mg/kg feed). In response to oral FB1 exposure, we observed common biological processes in the four organs, including predominant and recurrent processes (extracellular matrix organization, integrin activation, granulocyte chemotaxis, neutrophil migration, and lipid and sterol homeostasis), as well as more tissue-specific processes that appeared to be related to lipid outcomes (cell cycle regulation in jejunum, and gluconeogenesis in liver).
Keywords: fumonisin; liver; jejunum; spleen; Peyer’s patches; swine fumonisin; liver; jejunum; spleen; Peyer’s patches; swine

Share and Cite

MDPI and ACS Style

Dopavogui, L.; Polizzi, A.; Fougerat, A.; Gourbeyre, P.; Terciolo, C.; Klement, W.; Pinton, P.; Laffite, J.; Cossalter, A.-M.; Bailly, J.-D.; et al. Tissular Genomic Responses to Oral FB1 Exposure in Pigs. Toxins 2022, 14, 83. https://doi.org/10.3390/toxins14020083

AMA Style

Dopavogui L, Polizzi A, Fougerat A, Gourbeyre P, Terciolo C, Klement W, Pinton P, Laffite J, Cossalter A-M, Bailly J-D, et al. Tissular Genomic Responses to Oral FB1 Exposure in Pigs. Toxins. 2022; 14(2):83. https://doi.org/10.3390/toxins14020083

Chicago/Turabian Style

Dopavogui, Léonie, Arnaud Polizzi, Anne Fougerat, Pascal Gourbeyre, Chloé Terciolo, Wendy Klement, Philippe Pinton, Joëlle Laffite, Anne-Marie Cossalter, Jean-Denis Bailly, and et al. 2022. "Tissular Genomic Responses to Oral FB1 Exposure in Pigs" Toxins 14, no. 2: 83. https://doi.org/10.3390/toxins14020083

APA Style

Dopavogui, L., Polizzi, A., Fougerat, A., Gourbeyre, P., Terciolo, C., Klement, W., Pinton, P., Laffite, J., Cossalter, A.-M., Bailly, J.-D., Puel, O., Lippi, Y., Naylies, C., Guillou, H., Oswald, I. P., & Loiseau, N. (2022). Tissular Genomic Responses to Oral FB1 Exposure in Pigs. Toxins, 14(2), 83. https://doi.org/10.3390/toxins14020083

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop