Special Issue "Cnidarian Venom"
Deadline for manuscript submissions: closed (25 November 2022) | Viewed by 16074
Interests: investigation of peptides and polypeptides produced by the sea anemones: neurotoxins, alpha-pore-forming toxins (actinoporins), APETx-like toxins/peptides, inhibitors of Kunitz-type; searching of new members of peptides; studying of peptide structure-functional relationships and mechanisms of interaction with biological targets (various subtypes of Kv, Nav, and ASICs channel, TRPV1 receptor, serine proteases, cytoplasmic membranes); identification of pharmacological potential and perspectives applying.
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The search and the study of effective pharmacological compounds with high specificity of an action on biological targets is one of the priority areas of modern life sciences, which is stipulated by the spread of severe pathologies and infections that are difficult to treat among the population. One of the most promising natural sources of such compounds is the venom produced by marine animals of phylum Cnidaria (sea anemones, corals, jellyfishes, and hydroids). They are a complex mixture of toxins both of protein and nonprotein nature. Used by animals for protection, prey capture and digestion, as well as intraspecific competition, these compounds act at low concentrations, but with high specificity for biological targets, such as proteases, cytoplasmic membranes, ion channels/receptors that play a functionally important role in physiological processes of different organisms. By modulating the functional activity of biological targets in a pathological state, cnidarian toxins are able to exert a pharmacological effect.
This Special Issue is focused on research works devoted to the search for and identification of new functionally active compounds produced by сnidarians, the determination of their structures and molecular mechanisms of interaction with biological targets, including the modulating effect of agonists and antagonists on ion channels participating in the pathological processes of cardiovascular and nervous systems, the development of oncology, etc., the assessment of the pharmacological and therapeutic potential of compounds by in vivo, in vitro, and in silico methods, as well as the achievements of omix technologies in the study of structure–functional relationships and genetic diversity of protein compounds. Editors also welcome review articles summarizing experimental results and achievements in the abovementioned research areas as well short reports on new original experimental and theoretical works devoted to these unique marine venomous animals.
Dr. Margarita Monastyrnaya
Manuscript Submission Information
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- cnidarian phylum
- venom evolution
- biological templates
- pharmacological potential