Special Issue "Clinical and Molecular Analytic in Neuro-Oncology"

A special issue of Tomography (ISSN 2379-139X). This special issue belongs to the section "Cancer Imaging".

Deadline for manuscript submissions: 30 April 2023 | Viewed by 3255

Special Issue Editors

Dr. Alessandro Pesce
E-Mail Website
Guest Editor
Neurosurgery Unit, Santa Maria Goretti Hospital, Latina (LT), Italy
Interests: gliobastoma; intrinsic brain tumors; spinal intramedullary tumors
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Angelo Pompucci
E-Mail Website
Guest Editor
Santa Maria Goretti Hospital, 95121 Latina, Italy
Interests: spinal intramedullary tumors; primary brain tumors
Prof. Dr. Maurizio Salvati
E-Mail Website
Guest Editor
Istituto Neurologico Mediterraneo Neuromed, 30085 Pozzill, Italy
Interests: glioblastoma; primary brain tumors; low-grade gliomas; spinal intramedullary tumors
Prof. Dr. Alessandro Frati
E-Mail Website
Guest Editor
Neurosurgery Division, Human Neurosciences Department, Sapienza University, 00135 Rome, Italy
Interests: gliobastoma; intrinsic brain tumors; spinal intramedullary tumors; eloquent area neurosurgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

In the last years, great steps beyond in the understanding of the molecular pathophysiology of both primary and metastatic brain tumors have been made, thus producing a notable improvement of  their clinical management. The role of the 1p/19q translocation along with the IDH mutation status have been unanimously recognized and acknowledged as key factor for defining the biological behavior of the lesions, as well as MGMT methylation status has been extensively investigated as predictor of the treatment response in the primary brain neoplasms.  Such specific molecular patterns have been even associated to precise radiological appearances and clinical phenotypes, such as for instance in the more extensive expected neuropsychological impairment in patients suffering from IDH wild type Diffuse Astrocytomas in respect to their mutated counterparts. In Brain Metastases (BM) research, a wave of molecular findings has renewed our old conception of the “metastatic phenotype”, transforming it in a more wide and complex network of interactions between cytokines, microenvironment and adhesions molecules. The advanced Neuroimaging research is currently providing an increasing amount of evidences concerning the radiological implications of the molecular phenotypes of the lesions; this is not only particularly significant for PBTs and BMs, but for intracranial meningiomas and lymphomas either.

Therefore, with pleasure, we invite investigators to contribute to this Special Issue with original research articles, review articles and meta-analysis articles focusing on the current knowledge of the molecular pathogenesis of the Brain Tumors, with special regard to their clinical, radiological and surgical implications for the Neuro-oncologic practice.

Dr. Alessandro Pesce
Prof. Dr. Angelo Pompucci
Prof. Dr. Maurizio Salvati
Prof. Dr. Alessandro Frati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tomography is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Glioblastoma
  • Primary Brain Tumors
  • Low-grade gliomas
  • Spinal intramedullary tumors
  • Brain metastases
  • MRI Spectroscopy
  • Molecular analytic in Neuro-oncology
  • Advanced Neuroimaging in Neuro-oncology

Published Papers (4 papers)

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Research

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Article
Extradural Clinoidectomy in Clinoidal Meningiomas: Analysis of the Surgical Technique and Evaluation of the Clinical Outcome
Tomography 2022, 8(5), 2360-2368; https://doi.org/10.3390/tomography8050197 - 23 Sep 2022
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Abstract
The surgical treatment of clinoidal meningiomas is currently still discussed in the literature. Different surgical approaches have been proposed and evaluated, in multiple studies, in order to improve the surgical outcomes. The aim of this study is to evaluate the advantages of extradural [...] Read more.
The surgical treatment of clinoidal meningiomas is currently still discussed in the literature. Different surgical approaches have been proposed and evaluated, in multiple studies, in order to improve the surgical outcomes. The aim of this study is to evaluate the advantages of extradural clinoidectomy in the context of tumor removal radicality for visual function improvement. A retrospective analysis was performed on 74 patients—of which 26 patients with clinoidal meningiomas were in group III, according to Al Mefty classification—who underwent surgery at the Policlinico Umberto I Hospital between 2000 and 2019. Further, extradural clinoidectomy was performed on 15 patients (Group A), and 11 patients underwent the pterional approach only (Group B). Additionally, visual impairment was present in all 26 patients before surgery. Next, visual function assessment was performed on all patients, both in presurgery and postsurgery. Radiological follow up was performed at 3 and 6 months, and then every 12 months. Gross Total Resection (GTR) was achieved in 13/15 (86.7%) patients who underwent clinoidectomy, and in 4/11 (36.4%) patients who did not undergo clinoidectomy. Visual function improvement was achieved in 12/15 (80%) patients who underwent clinoidectomy and in 4 of 11 (36.4%) who did not undergo clinoidectomy. According to our study, extradural clinoidectomy is the most suitable method for facilitating the gross total resection of clinoidal meningiomas. Our experience and data suggest that a higher rate of total resection and, subsequently, the best visual outcomes are achieved. Extradural drilling via the anterior clinoid process reveals a wider surgical corridor for meticulous tumor resection. Full article
(This article belongs to the Special Issue Clinical and Molecular Analytic in Neuro-Oncology)
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Article
Peritumoral Brain Edema in Relation to Tumor Size Is a Variable That Influences the Risk of Recurrence in Intracranial Meningiomas
Tomography 2022, 8(4), 1987-1996; https://doi.org/10.3390/tomography8040166 - 08 Aug 2022
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Abstract
Peritumoral brain edema (PBE) is common in intracranial meningiomas (IM) and can increase their morbidity. It is not uncommon for a neurosurgeon to confront meningiomas with a large proportion of PBE independently from the site and size of the contrast-enhancing lesion with increased [...] Read more.
Peritumoral brain edema (PBE) is common in intracranial meningiomas (IM) and can increase their morbidity. It is not uncommon for a neurosurgeon to confront meningiomas with a large proportion of PBE independently from the site and size of the contrast-enhancing lesion with increased surgical risks. We performed a retrospective review of 216 surgically-treated patients suffering from IM. We recorded clinical, biological, and radiological data based on the rate of tumor and edema volume and divided the patients into a group with high Edema/Tumor ratio and a group with a low ratio. We investigated how the ratio of edema/lesion may affect the outcome. Multivariate analysis was performed for the two groups. Smokers were found to be more likely to belong to the high-rate group. The edema/tumor ratio did not affect the surgical radicality; however, independently of the biological sub-type, WHO grading, and EOR, a higher frequency of recurrence is shown in patients with a high edema/tumor ratio (70.5% vs. 8.4%. p < 0.01). There is evidence to suggest that the blood-brain barrier (BBB) damage from smoke could play a role in an increased volume of PBE. The present study demonstrates that IMs showing a high PBE ratio to tumor volume at diagnosis are associated with a smoking habit and a higher incidence of recurrence independently of their biological type and grading. Full article
(This article belongs to the Special Issue Clinical and Molecular Analytic in Neuro-Oncology)
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Article
Is It Worth Considering Multicentric High-Grade Glioma a Surgical Disease? Analysis of Our Clinical Experience and Literature Review
Tomography 2021, 7(4), 523-532; https://doi.org/10.3390/tomography7040045 - 05 Oct 2021
Cited by 3 | Viewed by 979
Abstract
Introduction. The simultaneous presence of multiple foci of high-grade glioma is a rare condition with a poor prognosis. By definition, if an anatomical connection through white matter bundles cannot be hypothesized, multiple lesions are defined as multicentric glioma (MC); on the other hand, [...] Read more.
Introduction. The simultaneous presence of multiple foci of high-grade glioma is a rare condition with a poor prognosis. By definition, if an anatomical connection through white matter bundles cannot be hypothesized, multiple lesions are defined as multicentric glioma (MC); on the other hand, when this connection exists, it is better defined as multifocal glioma (MF). Whether surgery can be advantageous for these patients has not been established yet. The aim of our study was to critically review our experience and to compare it to the existing literature. Materials and Methods. Retrospective analysis of patients operated on for MC HGG in two Italian institutions was performed. Distinction between MC and MF was achieved through revision of MR FLAIR images. Clinical and radiological preoperative and postoperative data were analyzed through chart revision and phone interviews. The same data were extracted from literature review. Univariate and multivariate analyses were conducted for the literature review only, and the null hypothesis was rejected for a p-value ≥ 0.05. Results. Sixteen patients met the inclusion criteria; male predominance and an average age of 66.5 years were detected. Sensory/motor deficit was the main onset symptom both in clinical study and literature review. A tendency to operate on the largest symptomatic lesion was reported and GTR was reached in the majority of cases. GBM was the histological diagnosis in most part of the patients. OS was 8.7 months in our series compared to 7.5 months from the literature review. Age ≤ 70 years, a postoperative KPS ≥ 70, a GTR/STR, a second surgery and adjuvant treatment were shown to be significantly associated with a better prognosis. Pathological examination revealed that MC HGG did not originate by LGG. Conclusions. MC gliomas are rare conditions with high malignancy and a poor prognosis. A maximal safe resection should be attempted whenever possible, especially in younger patients with life-threatening large mass. Full article
(This article belongs to the Special Issue Clinical and Molecular Analytic in Neuro-Oncology)
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Case Report
Full-Thickness Craniodural Metastasis with Leptomeningeal Infiltration of Salivary Origin: A Radiological Lesson and a Technical Remark
Tomography 2022, 8(5), 2164-2170; https://doi.org/10.3390/tomography8050181 - 27 Aug 2022
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Abstract
Calvarial metastases are a relatively rare entity, with an overall incidence of 3–4%. Among these cases, metastases arising from salivary gland cancers are even rarer; in fact, large studies regarding salivary gland tumors showed that brain metastases are observed in 0.8% of the [...] Read more.
Calvarial metastases are a relatively rare entity, with an overall incidence of 3–4%. Among these cases, metastases arising from salivary gland cancers are even rarer; in fact, large studies regarding salivary gland tumors showed that brain metastases are observed in 0.8% of the cases. Generally, bone metastases have been described in proximity to primary tumors, while bloodstream-disseminated lesions are often located inside the brain parenchyma. During every surgical step, traction on lower-lying infiltrated tissues must be avoided in order to successfully remove the lesion. This case report presents the first ever case of a 67-year-old woman affected by submandibular gland undifferentiated adenocarcinoma metastasis with a full-thickness involvement of the calvarium, pachy- and leptomeninges. Full article
(This article belongs to the Special Issue Clinical and Molecular Analytic in Neuro-Oncology)
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