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3D Printed Microfluidic Devices

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensor Materials".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 10056

Special Issue Editors


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Guest Editor
MEMS, Microfluidics and Nanoelectronics (MMNE) Lab, Department of Electrical and Electronics Engineering, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, India
Interests: smart sensors; energy harvesters; microfluidics; MEMS; printed electronics; nanoelectronics; wearable devices; organ on chip; point-of-care devices
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Co-Guest Editor
School of Engineering, Macquarie University, Sydney, NSW 2109, Australia
Interests: smart sensors; sensing technology; WSN; IoT; ICT; smart grid; energy harvesting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics is a well-proven and well-applied field, which has now moved towards real-life fully robust and automated applications. With rigorous properties amenable enough to be used in a variety of areas, microfluidics has evolved into a contemporary field by incorporating various other leading methods and processes. One of the basic features of this technology is the evolution of new and novel fabrication technologies. One such technology is 3D printing, where a 3D microfluidic device can be fabricated in a fully one-step manner by feeding a 3D design to the printer in a fully robotic way. Evidently, a lot of work is underway to realize various sensing and monitoring platform technologies. This Special Issue focuses on publishing original, significant, and visionary papers describing the development of 3D-printed devices, their applications, and future scope towards the development of fully integrated, automated, and robust microfluidic devices. The Special Issue is a broad platform to publish recent developments to realize efficient, 3D-printed microsensors and their wide-ranging applications.

Dr. Sanket Goel
Guest Editor

Manuscript Submission Information

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Keywords

  • biosensor
  • biofuel cell
  • smart sensors
  • rapid prototyping
  • MEMS sensors
  • point-of-care diagnostics
  • optical detection
  • electrical/electrochemical detection

Published Papers (3 papers)

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Research

13 pages, 1726 KiB  
Communication
Modelling of Power-Law Fluid Flow Inside a Piezoelectric Inkjet Printhead
by Ju Peng, Jin Huang and Jianjun Wang
Sensors 2021, 21(7), 2441; https://doi.org/10.3390/s21072441 - 01 Apr 2021
Cited by 4 | Viewed by 2258
Abstract
Piezoelectric three-dimensional inkjet printing has been used to manufacture heterogeneous objects due to its high level of flexibility. The materials used are non-Newtonian inks with complex rheological properties, and their behavior in the context of inkjet printing has not been fully understood: for [...] Read more.
Piezoelectric three-dimensional inkjet printing has been used to manufacture heterogeneous objects due to its high level of flexibility. The materials used are non-Newtonian inks with complex rheological properties, and their behavior in the context of inkjet printing has not been fully understood: for example, the fact that the shear-thinning viscosity affects the droplet generation. Therefore, a control strategy coping with shear-thinning behaviors is needed to ensure printing consistency. In this paper, a novel model-based approach is presented to describe the shear-thinning ink dynamics inside the piezoelectric inkjet printhead, which provides the basis to design the excitation parameters in a systematic way. The dynamic equation is simplified into a quasi-one-dimensional equation through the combination of the boundary layer theory and the constitutive equation of the power-law fluid, of which the viscosity is shear-thinning. Based on this, a nonlinear time-varying equivalent circuit model is presented to simulate the power-law fluid flow rate inside the tube. The feasibility and effectiveness of this model can be evaluated by comparing the results of computational fluid dynamics and the experimental results. Full article
(This article belongs to the Special Issue 3D Printed Microfluidic Devices)
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12 pages, 16313 KiB  
Article
Fabrication of Microfluidic Chips Based on an EHD-Assisted Direct Printing Method
by Xiang Chi, Xinyu Zhang, Zongan Li, Zhe Yuan, Liya Zhu, Feng Zhang and Jiquan Yang
Sensors 2020, 20(6), 1559; https://doi.org/10.3390/s20061559 - 11 Mar 2020
Cited by 8 | Viewed by 2787
Abstract
Microfluidic chips have been widely used in many areas such as biology, environmental monitoring, and micromixing. With the increasing popularity and complexity of microfluidic systems, rapid and convenient approaches for fabricating microfluidic chips are necessary. In this study, a method based on EHD [...] Read more.
Microfluidic chips have been widely used in many areas such as biology, environmental monitoring, and micromixing. With the increasing popularity and complexity of microfluidic systems, rapid and convenient approaches for fabricating microfluidic chips are necessary. In this study, a method based on EHD (electrohydrodynamic)-assisted direct printing is proposed. Firstly, the principle of EHD-assisted direct printing was analyzed. The influence of the operating voltage and moving speed of the work table on the width of a paraffin wax model was studied. Then, two kinds of paraffin wax molds for micromixing with channel widths of 120 μm were prepared. A polydimethylsiloxane (PDMS) micromixer was fabricated by replicating the paraffin wax mold, and the micromixing of blue and yellow dye was realized. The results show that EHD-assisted direct printing can be used to make complex microscale structures, which has the potential to greatly simplify the manufacturing process. Full article
(This article belongs to the Special Issue 3D Printed Microfluidic Devices)
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12 pages, 3063 KiB  
Article
3D-Printed Modular Microfluidic Device Enabling Preconcentrating Bacteria and Purifying Bacterial DNA in Blood for Improving the Sensitivity of Molecular Diagnostics
by Abdurhaman Teyib Abafogi, Jaewon Kim, Jinyeop Lee, Merem Omer Mohammed, Danny van Noort and Sungsu Park
Sensors 2020, 20(4), 1202; https://doi.org/10.3390/s20041202 - 21 Feb 2020
Cited by 16 | Viewed by 4518
Abstract
Molecular diagnostics for sepsis is still a challenge due to the presence of compounds that interfere with gene amplification and bacteria at concentrations lower than the limit of detection (LOD). Here, we report on the development of a 3D printed modular microfluidic device [...] Read more.
Molecular diagnostics for sepsis is still a challenge due to the presence of compounds that interfere with gene amplification and bacteria at concentrations lower than the limit of detection (LOD). Here, we report on the development of a 3D printed modular microfluidic device (3DpmμFD) that preconcentrates bacteria of interest in whole blood and purifies their genomic DNA (gDNA). It is composed of a W-shaped microchannel and a conical microchamber. Bacteria of interest are magnetically captured from blood in the device with antibody conjugated magnetic nanoparticles (Ab-MNPs) at 5 mL/min in the W-shaped microchannel, while purified gDNA of the preconcentrated bacteria is obtained with magnetic silica beads (MSBs) at 2 mL/min in the conical microchamber. The conical microchamber was designed to be connected to the microchannel after the capturing process using a 3D-printed rotary valve to minimize the exposure of the MSBs to interfering compounds in blood. The pretreatment process of spiked blood (2.5 mL) can be effectively completed within about 50 min. With the 3DpmμFD, the LOD for the target microorganism Escherichia coli O157:H7 measured by both polymerase chain reaction (PCR) with electrophoresis and quantitative PCR was 10 colony forming unit (CFU) per mL of whole blood. The results suggest that our method lowers the LOD of molecular diagnostics for pathogens in blood by providing bacterial gDNA at high purity and concentration. Full article
(This article belongs to the Special Issue 3D Printed Microfluidic Devices)
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