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Organ-on-a-Chip and Biosensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 11494

Special Issue Editors


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Guest Editor
Center for Microelectromechanical Systems; University of Minho; 4800-058 Guimaraes, Portugal
Interests: nanotechnology; nanomedicine; biosensors; drug delivery; hyperthermia; microfluidic devices
Special Issues, Collections and Topics in MDPI journals

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Guest Editor

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Guest Editor
Mechanical Engineering Department, Minho University, Campus de Azurém, 4800-058 Guimarães, Portugal
Interests: biomicrofluidics; microcirculation; biofluid mechanics; blood-on-chips; conventional and confocal micro-PIV; nanofluids; energy and environment
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Microfabrication and Exploratory Nanotechnology, Micro and Nanofabrication Department, International Iberian Nanotechnology Laboratory, Braga, Portugal
Interests: microfluidics; nanotechnology; micro- and nano-fabrication; biofluids

Special Issue Information

Dear Colleagues,

Organ-on-a-chip platforms—microscale recapitulations of human organs—is a hot-topic for human healthcare that promises to improve drug and nanocarrier development pipelines, personalized drug administration, as well as early detection of diseases or body disorders, by reducing the existent bias between preclinical and clinical trials. However, the integration of robust biosensing systems remains a challenge that needs to be suppressed for the standardization of this technology.

In this regard, this Special Issue on “Organ-on-a-Chip and Biosensors” seeks to gather the ultimate breakthroughs and innovative development techniques done in this multidisciplinary area, aiming toward an end-use for this technology. Therefore, it is our pleasure to invite you to submit a manuscript for this Special Issue. Full papers, short communications, and reviews are welcome. Examples of application areas include but are not limited to drug screening and discovery, theranostic nanoparticles screening, cellular/organ event monitoring, microfluidic cell capture, and cell/tissue analysis by multiplexed biosensor systems.

Dr. Raquel Rodrigues
Prof. Dr. Graça Minas
Prof. Dr. Rui Lima
Dr. Patrícia Sousa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Organ-on-a-chip
  • Biosensors
  • Microfluidics
  • Cell/tissues analysis
  • Micro/nanochemistry
  • MEMS/NEMS
  • Cell culture platforms

Published Papers (1 paper)

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Review

26 pages, 22394 KiB  
Review
3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review
by Violeta Carvalho, Inês Gonçalves, Teresa Lage, Raquel O. Rodrigues, Graça Minas, Senhorinha F. C. F. Teixeira, Ana S. Moita, Takeshi Hori, Hirokazu Kaji and Rui A. Lima
Sensors 2021, 21(9), 3304; https://doi.org/10.3390/s21093304 - 10 May 2021
Cited by 68 | Viewed by 10476
Abstract
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex [...] Read more.
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures. In contrast, 3D bioprinting, an evolving biofabrication method, focuses on the accurate deposition of hydrogel bioinks loaded with cells to construct tissue-engineered structures. The purpose of the present work is to conduct a systematic review (SR) of the published literature, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, providing a source of information on the evolution of organ-on-a-chip platforms obtained resorting to 3D printing and bioprinting techniques. In the literature search, PubMed, Scopus, and ScienceDirect databases were used, and two authors independently performed the search, study selection, and data extraction. The goal of this SR is to highlight the importance and advantages of using 3D printing techniques in obtaining organ-on-a-chip platforms, and also to identify potential gaps and future perspectives in this research field. Additionally, challenges in integrating sensors in organs-on-chip platforms are briefly investigated and discussed. Full article
(This article belongs to the Special Issue Organ-on-a-Chip and Biosensors)
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