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Photonics
Special Issues
Optical Sensors for Advanced Biomedical Applications
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Optical Sensors for Advanced Biomedical Applications

A special issue of Photonics (ISSN 2304-6732).

Deadline for manuscript submissions: 10 February 2025 | Viewed by 976

Special Issue Editors

Dr. Susana O. Catarino

E-Mail Website
Guest Editor
Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
Interests: lab-on-a-chip; optical microdevices; integrated optics; sensors and actuators; spectrophotometry
Special Issues, Collections and Topics in MDPI journals
Dr. Graça Minas

E-Mail Website
Guest Editor
Center for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
Interests: lab-on-a-chip; organ-on-a-chip; microsensors and mi-croactuators; integrated optics; microelectronics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last few decades, significant achievements have been accomplished in the field of optical sensors, namely in novel detection approaches, biosensing, microfabrication technologies, and integration in biomedical devices, featuring significant advancements in terms of functionality, versatility, and integration capabilities. Such improvements have revolutionized and tailored new applications of these sensors in the areas of medical diagnostics and therapeutics, lab-on-a-chip and organ-on-a-chip devices, monitoring of microfluidic environments, biomedical research, biotechnology, and environmental monitoring.

In this Special Issue, we welcome submissions (review articles, original research papers, and brief communications) contributing to the latest advances and challenges in optical sensors for advanced biomedical applications. Both experimental and simulation studies may be considered, aiming to report research and progress in their integration in the fields of, but not limited to, lab- and organ-on-a-chip devices, sensing and control systems for microfluidics, diagnosis and therapeutics, microfabrication of optical sensor devices, and the modeling and simulation of optical microsystems.

Dr. Susana O. Catarino
Dr. Graça Minas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostics and therapeutics
  • integrated optics
  • lab-on-a-chip
  • microelectronics
  • optics
  • sensors
  • modeling and simulation

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Published Papers (1 paper)

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15 pages, 8849 KiB  
Article
Complementary Metal Oxide Semiconductor-Based Optical Detection System for Fluidic Cellular Medium pH Quantification
by André A. Santos, Gabriel M. Ferreira, Paulo J. Sousa, Patrícia C. Sousa, Susana O. Catarino and Graça Minas
Photonics 2024, 11(12), 1130; https://doi.org/10.3390/photonics11121130 - 29 Nov 2024
Viewed by 458
Abstract
Accurate pH sensing is essential for the effective physiological control of the culture media in organ-on-a-chip (OoC) systems. This work proposes a miniaturized optical detection system, based on optical transmittance, for pH level quantification of the EGM™-2 Endothelial Cell Growth Medium-2 BulletKit™ culture [...] Read more.
Accurate pH sensing is essential for the effective physiological control of the culture media in organ-on-a-chip (OoC) systems. This work proposes a miniaturized optical detection system, based on optical transmittance, for pH level quantification of the EGM™-2 Endothelial Cell Growth Medium-2 BulletKit™ culture medium. Firstly, using a commercial spectrophotometric setup, a set of wavelengths (500, 560, and 600 nm) was selected, as these wavelengths assure distinctive slope variations for the different pH levels. Then, a current-to-frequency converter, based on a low-power Schmitt trigger model with a voltage enhancer, was proposed as the readout electronics and simulated in Cadence Tools using UMC L180 MM/RF technology. A resolution of 0.002 nA was achieved in the linear range of 30 pA to 3800 nA. A miniaturized system composed of a CMOS n-well/p-substrate photodiode and a polydimethilsiloxane (PDMS) microchannel for the culture media substrate was experimentally tested. For a pH range from 6.6 to 6.2, the results clearly demonstrate a magnitude shift of the slope signal, which becomes negative in basic media and positive in acidic media. Additionally, in the 500–560 nm spectral range, the amplitude of the slopes increases for both basic and acidic culture media. In the 560–600 nm range, the slope decreases progressively as the pH of the medium lowers. This miniaturized system was able to quantify the pH of the culture medium, showing potential to be integrated into an organ-on-a-chip device. Full article
(This article belongs to the Special Issue Optical Sensors for Advanced Biomedical Applications)
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