State-of-the-Art of Microfluidic Technologies and Applications in Iberia

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5410

Special Issue Editors


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Guest Editor
Mechanical Engineering Department, Minho University, Campus de Azurém, 4800-058 Guimarães, Portugal
Interests: biomicrofluidics; microcirculation; biofluid mechanics; blood-on-chips; conventional and confocal micro-PIV; nanofluids; energy and environment
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Mechanical Engineering Department, Technical University of Catalonia-BarcelonaTech, 08034 Barcelona, Spain
Interests: microfluidics; MEMS; micro-particle image velocimetry; plasma separation
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Guest Editor

Special Issue Information

Dear Colleagues,

In the last decade, microfabrication technologies in the Iberian Peninsula have become an important research area for microfluidic applications in different scientific and industrial fields, from the environment to pharmaceutics or biomedical engineering. In particular, biomedical microsystem technologies for diagnosis applications have provided a significant change in the way that modern biomedicine is performed in Iberia.

This Special Issue title “State-of-the-Art of Microfluidic Technologies and Applications in Iberia” invites researchers from the Iberian Peninsula to submit original and review articles on the latest advances and challenges in the development and applications of microfluidic technologies. Topics include but are not limited to:

  • Lab-on-a-chip technology;
  • Microfluidic systems;
  • Micromachining;
  • Microfabrication;
  • Fabrication of microfluidic devices;
  • Micro and nanoparticles;
  • Nanofluids;
  • Biomicrofluidics;
  • Organ-on-chips;
  • Microfluidic control;
  • Micropump of microfluidics;
  • Point of care diagnostics;
  • Biomedical microdevices;
  • Blood flow in microdevices;
  • Blood analogues in microdevices;
  • Acoustic streaming in microfluidics;
  • Heat and mass transport of micro and nanofluids;
  • Numerical simulation of flow, mass and heat transport in microdevices;
  • Microbubbles and microdroplets;
  • Biorheology in microfluidics;
  • Biosensors, optics and detection in microfluidics;
  • Image analysis in microfluidics;
  • Cell and particle transport in microfluidics;
  • Chemistry and biology on a chip.

Prof. Dr. Rui A. Lima
Prof. Dr. Jasmina Casals Terre
Dr. Diana Pinho
Prof. Dr. Graça Minas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • nanofluids
  • biomicrofluidics
  • micromachining
  • microfabrication
  • mass transport
  • heat transport
  • computational fluid dynamics
  • lab-on-a-chip
  • organ-on-chips
  • cell mechanics
  • microparticles
  • nanoparticles
  • blood flow
  • microcirculation
  • biosensors

Published Papers (3 papers)

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Research

13 pages, 4386 KiB  
Article
Numerical Model Validation of the Blood Flow through a Microchannel Hyperbolic Contraction
by Filipe Barbosa, Jorge Dueñas-Pamplona, Cristiano S. Abreu, Mónica S. N. Oliveira and Rui A. Lima
Micromachines 2023, 14(10), 1886; https://doi.org/10.3390/mi14101886 - 30 Sep 2023
Viewed by 1125
Abstract
A computational fluid dynamics (CFD) model of blood flow through hyperbolic contraction with a discrete phase model (DPM) was experimentally validated. For this purpose, the positions and velocities of red blood cells (RBCs) flowing in a microchannel with hyperbolic contraction were experimentally assessed [...] Read more.
A computational fluid dynamics (CFD) model of blood flow through hyperbolic contraction with a discrete phase model (DPM) was experimentally validated. For this purpose, the positions and velocities of red blood cells (RBCs) flowing in a microchannel with hyperbolic contraction were experimentally assessed using image analysis techniques, and were subsequently compared with the numerical results. The numerically and experimentally obtained velocity fields were in good agreement, with errors smaller than 10%. Additionally, a nearly constant strain rate was observed in the contraction region, which can be attributed to the quasilinear increase in the velocity along the hyperbolic contraction. Therefore, the numerical technique used was validated due to the close similarity between the numerically and experimentally obtained results. The tested CFD model can be used to optimize the microchannel design by minimizing the need to fabricate prototypes and evaluate them experimentally. Full article
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10 pages, 3280 KiB  
Article
Labeling on a Chip of Cellular Fibronectin and Matrix Metallopeptidase-9 in Human Serum
by Briliant Adhi Prabowo, Carole Sousa, Susana Cardoso, Paulo Freitas and Elisabete Fernandes
Micromachines 2022, 13(10), 1722; https://doi.org/10.3390/mi13101722 - 12 Oct 2022
Cited by 1 | Viewed by 1484
Abstract
We present a microfluidic chip for protein labeling in the human serum-based matrix. Serum is a complex sample matrix that contains a variety of proteins, and a matrix is used in many clinical tests. In this study, the device performance was tested using [...] Read more.
We present a microfluidic chip for protein labeling in the human serum-based matrix. Serum is a complex sample matrix that contains a variety of proteins, and a matrix is used in many clinical tests. In this study, the device performance was tested using commercial serum samples from healthy donors spiked with the following target proteins: cellular fibronectin (c-Fn) and matrix metallopeptidase 9 (MMP9). The microfluidic molds were fabricated using micro milling on acrylic and using stereolithography (SLA) three-dimensional (3D) printing for an alternative method and comparison. A simple quality control was performed for both fabrication mold methods to inspect the channel height of the chip that plays a critical role in the labeling process. The fabricated microfluidic chip shows a good reproducibility and repeatability of the performance for the optimized channel height of 150 µm. The spiked proteins of c-Fn and MMP9 in the human serum-based matrix, were successfully labeled by the functionalized magnetic nanoparticles (MNPs). The biomarker labeling occurring in the serum was compared using a simple matrix sample: phosphate buffer. The measured signals obtained by using a magnetoresistive (MR) biochip platform showed that the labeling using the proposed microfluidic chip is in good agreement for both matrixes, i.e., the analytical performance (sensitivity) obtained with the serum, near the relevant cutoff values, is within the uncertainty of the measurements obtained with a simple and more controlled matrix: phosphate buffer. This finding is promising for stroke patient stratification where these biomarkers are found at high concentrations in the serum. Full article
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20 pages, 3941 KiB  
Article
Analysis of a Vegetable Oil Performance in a Milling Process by MQL Lubrication
by Inês S. Afonso, José Pereira, António E. Ribeiro, Joana S. Amaral, Nuno Rodrigues, José R. Gomes, Rui Lima and João Ribeiro
Micromachines 2022, 13(8), 1254; https://doi.org/10.3390/mi13081254 - 4 Aug 2022
Cited by 4 | Viewed by 1822
Abstract
In this work, we carried out a comparison between the dry machining of an aluminum block with conventional cutting oil and a block with vegetable oil. The two oils had different flow rates. Using the Taguchi method, it was possible to determine the [...] Read more.
In this work, we carried out a comparison between the dry machining of an aluminum block with conventional cutting oil and a block with vegetable oil. The two oils had different flow rates. Using the Taguchi method, it was possible to determine the matrices for optimizing the best parameters for each group of tests. Then, we studied the utility of using vegetable oil as a cutting lubricant. We found that the vegetable oil studied in this work had good properties in terms of reducing cutting temperatures but was less effective than conventional cutting oil in reducing the surface roughness of the machined part. Tribological tests were carried out to understand the influence of the selected lubricants in reducing friction and wear. After the sliding experiments, which were performed without lubrication in the presence of the same lubricants that were used in the machining tests and in the presence of distilled water, we concluded that vegetable oil has satisfactory lubricating properties that are similar to those of the conventional cutting fluid, indicating a potential for consideration as an effective alternative to the conventional cutting fluid, with economic, environmental, and health advantages. Full article
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