Biomaterial Applications in Polymer Processing and Drug Design

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 1655

Special Issue Editors


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Guest Editor
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Skłodowskiej, 41-819 Zabrze, Poland
Interests: polymer processing; drug design

E-Mail Website
Guest Editor
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34, M. Curie-Skłodowska St., 41-800 Zabrze, Poland
Interests: three-dimensional printing; (bio)degradable polyester; prototype container; composability ; biodegradability; weathering test; (bio)degradable polyesters; hydrolytic degradation; defect; shrinkage after post-processing heat treatment; electrospinning; drug delivery; PLGA; propolis; burn wounds; PCL; titanium(iv)-oxo complex; composite; physicochemical properties; photocatalytic activity; reactive oxygen species; antimicrobial activity; wound; dressing; biodegradable; polymer; nonwoven

E-Mail Website
Guest Editor
Center of Polymer and Carbon Materials of the Polish Academy of Sciences, 41-819 Zabrze, Poland
Interests: polymers

Special Issue Information

Dear Colleagues,

In the realm of biomedical research, the fusion of biomaterials, polymer processing, and drug design heralds a new era of innovation and breakthroughs. With a focus on leveraging biomaterials for drug delivery systems, tissue engineering, and regenerative medicine, this interdisciplinary field is poised to significantly improve healthcare.

This Special Issue, entitled “Biomaterial Applications in Polymer Processing and Drug Design”, is dedicated to showcasing the latest advancements in this dynamic area of study. From novel polymer processing methodologies like electrospinning and micoinjection molding, to the synthesis and characterization of biomaterials tailored for specific biomedical applications, this issue aims to illuminate the cutting-edge research driving progress within the field.

Dr. Mateusz Stojko
Dr. Michał Sobota
Dr. Jakub Włodarczyk
Guest Editors

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Keywords

  • biomaterials
  • polymer processing
  • drug design
  • drug delivery systems
  • tissue engineering
  • regenerative medicine
  • electrospinning
  • microneedle fabrication
  • 3D bioprinting
  • extrusion
  • injection molding
  • biomedical applications

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Published Papers (1 paper)

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Research

22 pages, 2852 KiB  
Article
Modification of Cotton with Chitosan: Deposition of Copper(II) Sulfate by Complexation Copper Ions
by Małgorzata Świerczyńska, Zdzisława Mrozińska, Michał Juszczak, Katarzyna Woźniak and Marcin H. Kudzin
Processes 2024, 12(12), 2772; https://doi.org/10.3390/pr12122772 - 5 Dec 2024
Viewed by 1271
Abstract
This study introduces a novel approach for enhancing the functional properties of cotton fibers through complexation of copper sulfate, and subsequent combination with chitosan (COT-CuSO4-CTS). Our preliminary investigations focused on the development composites as candidate materials for functional coatings with antimicrobial [...] Read more.
This study introduces a novel approach for enhancing the functional properties of cotton fibers through complexation of copper sulfate, and subsequent combination with chitosan (COT-CuSO4-CTS). Our preliminary investigations focused on the development composites as candidate materials for functional coatings with antimicrobial properties. The materials were thoroughly characterized via scanning electron microscopy (SEM) and optical microscopy, providing insights into their structural features and composition. The findings show that the modified cotton materials exhibit potent antimicrobial activity. Specifically, the COT-CuSO4 and COT-CuSO4-CTS samples demonstrated zones of inhibition against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, confirming their ability to reduce microbial growth significantly. The incorporation of a chitosan layer significantly enhanced the Ultraviolet Protection Factor (UPF) of the cotton fabric from 3.37 to over 50, indicating exceptional UV shielding capabilities, while copper(II) oxide treatment provided a moderate UPF value of 14.56. Blood compatibility studies further revealed that COT-CuSO4 and COT-CuSO4-CTS fabrics influence coagulation parameters, with a marked prolongation in activated partial thromboplastin time (aPTT) and prothrombin time (PT) compared to untreated cotton. This anticoagulant effect is primarily linked to the presence of copper, although the addition of chitosan modulates this response, slightly reducing clotting times compared to COT-CuSO4 alone. Cytotoxicity and genotoxicity assessments using Peripheral Blood Mononuclear (PBM) cells indicated that untreated cotton was non-toxic and non-genotoxic. However, COT-CuSO4 and COT-CuSO4-CTS fabrics displayed a reduction in cell viability and induced DNA damage, highlighting their potential cytotoxic and genotoxic effects. Notably, COT-CuSO4-CTS showed lower cytotoxicity and genotoxicity than COT-CuSO4-CTS, suggesting that chitosan reduces the overall cytotoxic and genotoxic potential of the composite. Furthermore, plasmid DNA relaxation assays indicated that COT-CuSO4 and COT-CuSO4-CTS interact with DNA, with COT-CuSO4 exhibiting a stronger interaction than COT-CuSO4-CTS, consistent with the findings on PBM cells. Full article
(This article belongs to the Special Issue Biomaterial Applications in Polymer Processing and Drug Design)
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