2nd Edition of Natural Products for Drug Discovery and Development

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1016

Special Issue Editors

Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, Wuzhong No. 111, Renai Road, Suzhou 215123, China
Interests: peptide; drug discovery; molecular pharmacology; natural products; chemical biology
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Guest Editor
Wisdom Lake Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, Wuzhong No.111, Renai Road, Suzhou 215123, China
Interests: precision medicine; peptide drug discovery and design; mass spectrometry; proteomics-based target-identification, functional and structural characterization; high-throughput drug screening and validation; peptide and protein chemistry; molecular pharmacology; targeted protein modifiers; targeted drug delivery; natural products
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2. Department of Pharmacological Sciences, Faculty of Health Sciences, University of Macau, Macao, China
Interests: cardiovascular; neurodegenerative diseases and brain disorders; molecular pharmacology; mitochondrial functions; systems biology; genome; transcriptome; proteome; protein interaction network; natural product chemistry; Chinese medicine; peptide chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first edition of this Special Issue, “Natural Products for Drug Discovery and Development”, was published in Processes in 2021 and comprised 12 interesting papers (1 editorial, 9 articles, and 2 reviews), attracting many potential authors and readers with more than 16,000 views. Due to the large success of the first volume and the high interest in this topic, we decided to propose a second edition of this Special Issue, entitled “2nd Edition of Natural Products for Drug Discovery and Development”.

Natural products are defined as chemical compounds produced by living organisms, including plants, animals, insects, and microbes. For many years, natural products and their structural analogs have played key roles in drug discovery and development for many therapeutic areas, such as cancer, infectious diseases, cardiovascular diseases, and metabolic disorders. Some best-known examples include penicillin from Penicillium moulds as antibiotics, artemisinin from the plant Artemisia annua for malaria, ω-conotoxin MVIIA from the marine snail Conus magus for pain, and paclitaxel from the plant Taxus brevifolia for cancer.

This Special Issue of Processes, devoted to the topic of "Natural Products for Drug Discovery and Development", invites high-quality research papers and reviews focusing on new understandings and technologies being used in natural product research for drug discovery and therapeutic applications.

Topics of interest include, but are not limited to:

  • The discovery, identification, and biological evaluation of natural products;
  • Structure–activity relationships;
  • Target identification;
  • Molecular mechanisms;
  • New technologies to improve the drug discovery process of natural products.

Dr. Antony Kam
Dr. Shining Loo
Prof. Dr. Lee Simon Ming-Yuen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural product
  • discovery
  • structure–activity relationship
  • herbal medicine
  • molecular mechanism
  • high-throughput screening
  • target identification

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Published Papers (1 paper)

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Research

26 pages, 4296 KiB  
Article
Electron-Shuttling Characteristics of Cassia obtusifolia Seed Extracts and Antiviral Activities of Anthraquinone Compounds Through In Silico Studies
by Stephanie Claire M. Tiongson, Bor-Yann Chen, Kathlia A. De Castro-Cruz, Chung-Chuan Hsueh, Yeh Lien and Po-Wei Tsai
Processes 2025, 13(2), 458; https://doi.org/10.3390/pr13020458 - 8 Feb 2025
Viewed by 718
Abstract
Previous studies have linked the electron-shuttling properties of Traditional Chinese Medicine (TCM) species to antiviral efficacy. This study explores the antiviral potential of Cassia obtusifolia seeds through electrochemical analyses using microbial fuel cells (MFCs) and cyclic voltammetry (CV) complemented by in silico methods. [...] Read more.
Previous studies have linked the electron-shuttling properties of Traditional Chinese Medicine (TCM) species to antiviral efficacy. This study explores the antiviral potential of Cassia obtusifolia seeds through electrochemical analyses using microbial fuel cells (MFCs) and cyclic voltammetry (CV) complemented by in silico methods. The phytochemical contents and antioxidant activity of Cassia seed extracts were assessed and correlated with bioenergy generation and electrochemical stability. A principal component analysis (PCA) indicated that phytochemical and antioxidant activity influence Cassia’s power-generating potential. The MFC study revealed a 1.87-fold power amplification in unprocessed Cassia seed water extract (CTS-W), while CV analysis demonstrated enhanced electrochemical stability and reversibility due to the presence of electron-shuttling (ES) species. In silico analyses, including network pharmacology and molecular docking, provided supporting evidence for the antiviral potential of bioactive metabolites in Cassia seeds, particularly in targeting Hepatitis B virus-related genes. Furthermore, a mathematical model highlighted the superior therapeutic efficacy of electron-shuttling (ES) species compared to antioxidants in disease treatment. These findings demonstrate a strong correlation between the electron-shuttling properties and the antiviral potential of C. obtusifolia seed extracts, suggesting that bioenergy-mediated mechanisms may play a crucial role in the development of effective antiviral therapies. Full article
(This article belongs to the Special Issue 2nd Edition of Natural Products for Drug Discovery and Development)
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