Advances of Redox Status in Disease

Dear Colleagues,

Oxidants are considered a double-edged sword. On the one hand, a fine-tuned basal level is indispensable for redox signaling and cell homeostasis, promoting adaptations to new challenging environments. On the other hand, an uncontrolled production of oxidants can be detrimental for an organism, establishing a condition commonly known as Oxidative Stress (OxS). This complicated picture is further aggravated by the interdependent relationship existing between OxS and inflammation, which may have been at least partially responsible for the failure of past antioxidant clinical trials. Therefore, complete knowledge of both oxidant status and inflammation during a pathological condition could be essential for the selection of the right therapy and adjuvant antioxidants as well. Considering this point and the involvement of both OxS and inflammation in the pathogenesis of many clinical conditions (e.g., cardiovascular diseases, neurodegenerative disorders, metabolic conditions, and tumors), it urges one to advance the knowledge on redox status and inflammation in diseases.

On these bases, we invite you to submit your latest research findings or review articles to this Special Issue, which is focused on the assessment of redox status in pathologic human conditions and, if possible, of the underlying inflammation. Both in vitro and in vivo studies relating to these topics will be suitable for the current Issue. We look forward to your contribution.

Dr. Alessandro Trentini
Dr. Maria Cristina Manfrinato
Prof. Dr. Tiziana Bellini
Guest Editors

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