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Processes
Special Issues
Extraction, Separation, and Purification of Bioactive Compounds
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Extraction, Separation, and Purification of Bioactive Compounds

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Separation Processes".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1791

Special Issue Editors

Dr. Martina Jakovljević Kovač

E-Mail Website
Guest Editor
Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 18, 31000 Osijek, Croatia
Interests: extraction; plants; bioactive components; chromatographic methods; deep eutectic solvents
Prof. Dr. Stela Jokić

E-Mail Website
Guest Editor
Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 18, 31000 Osijek, Croatia
Interests: response surface methodology; extraction; solubility; supercritical carbon dioxide; industrial design; antioxidant activity; flavonoids; antioxidants; phenolic compounds; polyphenols
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Given the growing awareness of the importance and chemical diversity of bioactive components, their application is rapidly expanding across the food, pharmaceutical, and cosmetic sectors. Consequently, it is vital that we develop efficient extraction and purification methods that maximize component yields. The yield of bioactive components is influenced by various factors, such as the solvent and sample characteristics, solid-to-liquid ratio, extraction time, and temperature. Therefore, these parameters are frequently optimized for specific groups of compounds or for individual compounds to enhance the extraction efficiency. However, even if the efficiency of extraction is increased, purification still presents substantial challenges due to different impurities in extracts, interference from other compounds, and the need to preserve the stability and activity of the bioactive compounds. The extracts usually require additional concentration and purification steps, which often lead to reduced yields of the desired bioactive substances.

For this Special Issue on “Extraction, Separation, and Purification of Bioactive Compounds”, we welcome submissions of high-quality work focusing on extraction and purification methods that provide possible solutions to the numerous shortcomings of conventional extraction and purification techniques. This Special Issue will also cover recent advances in the development and application of novel solvents in extraction, as well as innovative extraction and purification techniques.

Topics include, but are not limited to, the following:

  • the extraction, separation, and purification of bioactive compounds;
  • innovative extraction and purification techniques in bioactive compounds;
  • the development and application of novel solvents for extraction;
  • the optimization of extraction, separation, or purification processes;
  • the influence of extraction and purification parameters on extraction yield.

Dr. Martina Jakovljević Kovač
Prof. Dr. Stela Jokić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extraction
  • purification
  • bioactive components
  • solvents
  • chromatography
  • optimization
  • innovative techniques

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Published Papers (2 papers)

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Research

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18 pages, 4752 KiB  
Article
Antidiabetic Potential of Chinese Giant Salamander (Andrias davidianus)-Derived Peptide: Isolation and Characterization of DPP4 Inhibitory Peptides
by Chi-Wei Lee, Christoper Caesar Yudho Sutopo, Jong-Yuan Lee, Wei-Ting Hung, Yu-Kuo Chen and Jue-Liang Hsu
Processes 2025, 13(2), 453; https://doi.org/10.3390/pr13020453 - 7 Feb 2025
Viewed by 701
Abstract
Amid the global rise in type 2 diabetes, natural peptide-based therapies provide a safer alternative to synthetic drugs with fewer side effects. This study highlights the antidiabetic potential of peptides derived from cultured Chinese giant salamander (CGS) meat hydrolyzed by Alcalase 2.4L FG [...] Read more.
Amid the global rise in type 2 diabetes, natural peptide-based therapies provide a safer alternative to synthetic drugs with fewer side effects. This study highlights the antidiabetic potential of peptides derived from cultured Chinese giant salamander (CGS) meat hydrolyzed by Alcalase 2.4L FG through DPP4 inhibitory activity. The hydrolysate exhibited significant DPP4 inhibitory activity, with an IC50 value of 1317.0 ± 29.5 μg/mL. Using activity-guided modified-SPE fractionation, the most potent DPP4 inhibitory peptide, PPAAQLL (PL7), was identified from CGS alcalase hydrolysate, with an IC50 of 230.1 ± 4.9 μM. PL7 was identified as a non-competitive inhibitor through enzyme kinetic studies, and intermolecular docking simulations suggested that it does not interact with the active site of DPP4. Additionally, PL7’s stability against DPP4 and simulated gastrointestinal protease digestion suggested that its inhibitory activity remains intact, indicating potential for effective oral administration. SRM quantification analysis revealed nearly a six-fold enrichment of PL7 in the RP-SPE fraction S1 compared to the crude hydrolysate, underscoring the effectiveness of the fractionation method. These findings highlight CGS alcalase hydrolysate as a promising source of DPP4 inhibitory peptides for managing type 2 diabetes. Future studies should focus on the in vivo efficacy, bioavailability, and pharmacokinetics of PL7. Full article
(This article belongs to the Special Issue Extraction, Separation, and Purification of Bioactive Compounds)
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Review

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23 pages, 1443 KiB  
Review
High-Pressure Extraction Techniques for Efficient Recovery of Flavonoids and Coumarins from Flower Seeds
by Carolina E. Demaman Oro, João H. C. Wancura, Maicon S. N. dos Santos, Luciana D. Venquiaruto, Rogério M. Dallago and Marcus V. Tres
Processes 2025, 13(2), 300; https://doi.org/10.3390/pr13020300 - 22 Jan 2025
Viewed by 854
Abstract
The extraction of bioactive compounds, such as flavonoids and coumarins, from natural sources has gained significant attention due to their potential health benefits. This review aims to explore the application of high-pressure extraction processes, particularly supercritical fluid extraction (SFE) and pressurized liquid extraction [...] Read more.
The extraction of bioactive compounds, such as flavonoids and coumarins, from natural sources has gained significant attention due to their potential health benefits. This review aims to explore the application of high-pressure extraction processes, particularly supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE), for obtaining flavonoids and coumarins from flower seeds. These techniques offer a greener, more efficient alternative to conventional extraction methods, minimizing the use of harmful solvents and improving the yield and purity of the target compounds. Flower seeds, a rich source of bioactive molecules, are an underutilized reservoir for these valuable compounds. For example, seeds from plants such as Calendula officinalis (calendula) and Helianthus annuus (sunflower) are rich in flavonoids and coumarins. The proposed review will examine the influence of extraction parameters—such as temperature, pressure, solvent choice, and extraction time—on the yield and quality of flavonoids and coumarins. This review aims to provide a comprehensive understanding of high-pressure extraction methods and optimize protocols for the efficient, sustainable extraction of flavonoids and coumarins from flower seeds. Full article
(This article belongs to the Special Issue Extraction, Separation, and Purification of Bioactive Compounds)
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