Dear Colleagues,

Manipulation of gene regulation is the most common and critical technique in various fields of molecular and cell biological research. It is not only essential for elucidation of mechanisms of cell behaviors in the molecular level, but it is also a fundamental operation for multi-disciplinary research. For instance, gene regulatory technology could integrate with nanotechnology, pharmacology, theranostic technology, drug delivery, molecular imaging, immunology, and neuroscience to approach the biomedical questions from benchside to the bedside. Although gene therapy has not been fully regarded as a modern approach for cancer treatment, the investigation of gene regulation remains essential for evalulating the prognosis of therapeutic efficacy. The genes of interest are also verstile, including coding RNA and non-coding RNA with various lengths. The technologies for gene regulation are also greatly improved for the purposes of stable and general expression, low immunogenicity, target specific editing, low or high cell selectivity, cliinical intension, combining cell therapy, and development of cancer vaccines. Drug discovery is also largely related to the technology of gene regulation to validate the potent drug mechanisms and precise medicine. Therefore, we enthusiastically invite papers presenting novel developments and inventions of gene expression technology with the values of basic research and clinical applications for cancer therapy. The appropriate topics may include but are not limited to the following:

• Genomic editing technology for expression of cancer targeting genes
• Biocompatible vehicles for cancer specific delivery of genes
• Advanced techniques for expression and regulation of coding RNA and non-coding RNA
• Bioinformatics-based design of technology for expression and regulation of genes in cancers and therapeutic implications

Prof. Dr. Yi-Jang Lee
Dr. Chun-Yuan Chang
Guest Editors

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• CRISPR/Cas9
• system biology
• transposon based gene delivery
• foamy virus, lentivirus, adenovirus and AAV
• coding RNA and non-coding RNA
• cancer
• Genomic editing