Green and Scalable Bioprocess Engineering: Enzymatic Systems, Process Intensification and Sustainable Applications
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".
Deadline for manuscript submissions: 10 December 2025 | Viewed by 41

Special Issue Editors
Interests: process design; bioprocess engineering; process modeling and simulation; green chemistry; enzyme technology; fermentation processes; scale-up and equipment design; biochemical reaction engineering; biomining, sustainable process development; bioeconomy; bioconversion; downstream processing; integrated biorefineries; data science; artificial intelligence
Interests: bioprocess engineering; environmental biotechnology; solid-state fermentation; enzyme production and applications; metabolic pathways; process scale-up; sustainable bioprocesses; bioreactor design; waste valorization; bioconversion of agro-industrial residues; bioeconomy; bioprocess intensification; biomining
Interests: organic synthesis; fermentation processes; enzymatic catalysis; scale-up and process development; pharmaceutical biotechnology; green synthesis routes; bioactive compound production; downstream purification; industrial enzymology; metabolic pathways; sustainable pharmaceutical processes; bioconversion; bioeconomy
Special Issue Information
Dear Colleagues,
The transition towards a bio-based and sustainable economy requires the development of efficient, scalable, and environmentally conscious bioprocesses. As industries seek alternatives to petroleum-based manufacturing, bioprocess engineering is a driving force behind the shift toward green and scalable manufacturing for the production of pharmaceuticals, bio-based chemicals, and value-added compounds.
Recent advances in enzymatic systems, process intensification, and upstream–downstream integration are enabling the development of greener and more robust bioprocesses. These innovations support both industrial and bio-pharmaceutical sectors, offering new pathways for the synthesis of therapeutic proteins, secondary metabolites, and specialty chemicals with reduced environmental impact.
This Special Issue on “Green and Scalable Bioprocess Engineering: Enzymatic Systems, Process Intensification and Sustainable Applications” aims to gather high-quality contributions that address the design, optimization, and scale-up of sustainable bioprocesses. We invite submissions that explore novel strategies in process development, biocatalysis, and bio-based production from a systems and engineering perspective.
Topics include, but are not limited to:
- Enzymatic biocatalysis for pharmaceutical and industrial applications
- Process intensification in fermentation and bioconversion systems
- Integration of upstream and downstream operations in continuous or semi-continuous modes
- Bioprocess scale-up and pilot-to-industrial implementation
- Green chemistry principles in bioprocess design and synthesis routes
- Valorization of renewable resources and biomass in the context of the bioeconomy
- Techno-economic and life-cycle assessments of sustainable bioprocesses
- Design of eco-efficient unit operations and bioreactor systems
- Application of sustainable solvents and low-impact raw materials
This Special Issue emphasizes the process and systems engineering dimension of bioprocess development. Both experimental and computational studies are welcome, particularly those that demonstrate a clear pathway toward greener, scalable, and industrially relevant biotechnological solutions.
We look forward to your contributions.
Dr. Carlos Ocampo-López
Dr. Margarita Ramirez-Carmona
Dr. Leidy Rendón-Castrillón
Guest Editors
Manuscript Submission Information
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Keywords
- enzymatic bioprocessing
- biopharmaceutical processes
- biocatalysis
- downstream processing
- scale-up
- process intensification
- green chemistry
- bio-based products
- circular bioeconomy
- biomass valorization
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