Special Issue "Molecular Imprinted Polymers: Challenges and Applications"

A special issue of Polymers (ISSN 2073-4360).

Deadline for manuscript submissions: 20 June 2019

Special Issue Editor

Guest Editor
Prof. Teresa Casimiro

LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
Website | E-Mail
Interests: synthesis and processing of polymers; molecular imprinted polymers; supercritical fluid technology; development of MIP based materials for separation, API purification, catalysis, drug delivery, sensors etc

Special Issue Information

Dear Colleagues,

Molecular imprinting is a very challenging area of research. The ability to replace expensive and complex affinity materials by Molecular Imprinted Polymers (MIPs) has high potentiality and very interesting materials have appeared in the last years. Despite the relevant works and the intensive research activity in the field, there is still lack of industrial applications of MIPs. This special issue aims to gather applications in different areas, with a special focus on MIP optimization including modeling, to improve the specificity and selectivity of active sites, new MIP applications, new and optimized production methodologies and technologies, scale-up strategies, fundamental mechanistic studies, (bio)sensors, progresses in analytical chemistry, nanotechnology, catalysis, MIP development for bio-recognition, etc.

The special issue invites papers and reviews in all areas of MIP application, with no restrictions, from fundamentals to final MIP use. It aims to highlight the advances that have been made in the field in the last years, while addressing big challenges still to be overcome in the field that could boost the use of MIPs in commercial applications.

Prof. Teresa Casimiro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

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Open AccessArticle
Fabrication of Water-Compatible Molecularly Imprinted Resin in a Hydrophilic Deep Eutectic Solvent for the Determination and Purification of Quinolones in Wastewaters
Polymers 2019, 11(5), 871; https://doi.org/10.3390/polym11050871
Received: 29 April 2019 / Revised: 7 May 2019 / Accepted: 10 May 2019 / Published: 13 May 2019
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Abstract
A novel water-compatible molecularly imprinted resin was prepared in a green solvent deep eutectic solvent (DES). Resorcinol and melamine, as functional monomers with an abundant hydrophilic group, such as –OH, –NH2 and –NH–, were introduced into the molecularly imprinted resin (MIR). Three [...] Read more.
A novel water-compatible molecularly imprinted resin was prepared in a green solvent deep eutectic solvent (DES). Resorcinol and melamine, as functional monomers with an abundant hydrophilic group, such as –OH, –NH2 and –NH–, were introduced into the molecularly imprinted resin (MIR). Three DESs (choline chloride-ethylene glycol, tetramethylammonium bromide-ethylene glycol and tetramethylammonium chloride-ethylene glycol) were used to synthesize the molecularly imprinted resin and the resulting deep eutectic solvent-based molecularly imprinted resins were characterized by particle size analysis, elemental analysis, scanning electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis. The resulting deep eutectic solvent-based molecularly imprinted resins were then applied to the adsorption of quinolones (ofloxacin) in water. The adsorption process of deep eutectic solvent-based molecularly imprinted resin followed the static adsorption model, Langmuir isotherm (R2 ≥ 0.9618) and kinetic model pseudo-second-order (R2 > 0.9814). The highest theory adsorption ability of the three kinds of deep eutectic solvent-based molecularly imprinted resins was more than 23.79 mg/g. The choline chloride-ethylene glycol-based MIR was applied to solid-phase extraction for the determination and purification of quinolones (e.g., ciprofloxacin and ofloxacin). The detection limit of deep eutectic solvent-based molecularly imprinted resin-solid-phase extraction method was less than 0.018 mg/L. The recoveries of the deep eutectic solvent-based molecularly imprinted resin-solid-phase extraction method at three spiked levels were 88.7–94.5%, with a relative standard deviation of ≤4.8%. The novel deep eutectic solvent-based molecularly imprinted resin-solid-phase extraction method is a simple, selective and accurate pre-treatment method and can be used to determine the quinolones in environmental water. Full article
(This article belongs to the Special Issue Molecular Imprinted Polymers: Challenges and Applications)
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Open AccessArticle
Luminescent Molecularly Imprinted Polymers Based on Covalent Organic Frameworks and Quantum Dots with Strong Optical Response to Quinoxaline-2-Carboxylicacid
Polymers 2019, 11(4), 708; https://doi.org/10.3390/polym11040708
Received: 15 March 2019 / Revised: 7 April 2019 / Accepted: 13 April 2019 / Published: 17 April 2019
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Abstract
Three-dimensional molecularly imprinted polymers (MIPs) based on quantum dots-grafted covalent organic frameworks (QDs-grafted COFs) are reported in this study. The compound 1,3,5-triformylphloroglucinol-P-phenylenediamine was used as COF material to react with the amino-modified CdSe/ZnS QDs by Schiff-base reactions. The amino-derived QDs reacted with quinoxaline-2-carboxylicacid [...] Read more.
Three-dimensional molecularly imprinted polymers (MIPs) based on quantum dots-grafted covalent organic frameworks (QDs-grafted COFs) are reported in this study. The compound 1,3,5-triformylphloroglucinol-P-phenylenediamine was used as COF material to react with the amino-modified CdSe/ZnS QDs by Schiff-base reactions. The amino-derived QDs reacted with quinoxaline-2-carboxylicacid (QCA) via a non-covalent interaction. The system combines the advantages of MIPs, COFs, and QDs for highly sensitive and selective QCA detection. The MIPs based on QDs-grafted COFs showed good chemical selectivity and thermal stability, as well as consistency in QCA optosensing. Under optimal conditions, the detection limit for QCA in meat and feed samples was 0.85 μmol L−1, over a linear concentration range of 1–50 μmol L−1. The current findings suggest a potential application of MIPs based on QDs-grafted COFs for the detection of trace levels of hazardous chemicals for food safety and environmental control. Full article
(This article belongs to the Special Issue Molecular Imprinted Polymers: Challenges and Applications)
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Open AccessArticle
Fabrication of Core-Shell Magnetic Molecularly Imprinted Nanospheres towards Hypericin via Click Polymerization
Polymers 2019, 11(2), 313; https://doi.org/10.3390/polym11020313
Received: 6 January 2019 / Revised: 28 January 2019 / Accepted: 3 February 2019 / Published: 13 February 2019
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Abstract
The core-shell structure molecularly imprinted magnetic nanospheres towards hypericin (Fe3O4@MIPs) were prepared by mercapto-alkyne click polymerization. The shape and size of nanospheres were characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). The nanospheres were analyzed by [...] Read more.
The core-shell structure molecularly imprinted magnetic nanospheres towards hypericin (Fe3O4@MIPs) were prepared by mercapto-alkyne click polymerization. The shape and size of nanospheres were characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). The nanospheres were analyzed by FTIR spectroscopy to verify the thiol-yne click reaction in the presence or absence of hypericin. The Brunauer–Emmet–Teller (BET) method was used for measuring the average pore size, pore volume and surface area. The Fe3O4@MIPs synthesized displayed a good adsorption capacity (Q = 6.80 µmol·g−1). In addition, so-prepared Fe3O4@MIPs showed fast mass transfer rates and good reusability. The method established for fabrication of Fe3O4@MIPs showed excellent reproducibility and has broad potential for the fabrication of other core-shell molecularly imprinted polymers (MIPs). Full article
(This article belongs to the Special Issue Molecular Imprinted Polymers: Challenges and Applications)
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Review

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Open AccessReview
Molecularly Imprinted Polymer Materials as Selective Recognition Sorbents for Explosives: A Review
Polymers 2019, 11(5), 888; https://doi.org/10.3390/polym11050888
Received: 27 March 2019 / Revised: 9 May 2019 / Accepted: 10 May 2019 / Published: 15 May 2019
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Abstract
Explosives are of significant interest to homeland security departments and forensic investigations. Fast, sensitive and selective detection of these chemicals is of great concern for security purposes as well as for triage and decontamination in contaminated areas. To this end, selective sorbents with [...] Read more.
Explosives are of significant interest to homeland security departments and forensic investigations. Fast, sensitive and selective detection of these chemicals is of great concern for security purposes as well as for triage and decontamination in contaminated areas. To this end, selective sorbents with fast binding kinetics and high binding capacity, either in combination with a sensor transducer or a sampling/sample-preparation method, are required. Molecularly imprinted polymers (MIPs) show promise as cost-effective and rugged artificial selective sorbents, which have a wide variety of applications. This manuscript reviews the innovative strategies developed in 57 manuscripts (published from 2006 to 2019) to use MIP materials for explosives. To the best of our knowledge, there are currently no commercially available MIP-modified sensors or sample preparation methods for explosives in the market. We believe that this review provides information to give insight into the future prospects and potential commercialization of such materials. We warn the readers of the hazards of working with explosives. Full article
(This article belongs to the Special Issue Molecular Imprinted Polymers: Challenges and Applications)
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Graphical abstract

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