Application and Chemical Characterization of Plant Natural Products

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2142

Special Issue Editor


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Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Università degli Studi di Palermo, I-90128 Palermo, Italy
Interests: essential oils chemical composition; plant chemistry

Special Issue Information

Dear Colleagues,

The plant kingdom is the main source of chemical diversity from which hundreds of organic molecular frameworks are produced, which means several thousands of compounds and hundreds of new molecules are discovered every day in industrial and academic laboratories around the world.

Nature still remains the most efficient and imaginative “synthetic chemist”, and this impressive mass of chemical knowledge is the grounds for the development of a potentially infinite number of new applications in the contexts of agriculture, food science, and pharmacology, without neglecting the very interesting new applications of plant products in the preservation of cultural heritage artefacts.

The isolation and chemical characterization of new complex structures remain fascinating challenges for natural product researchers.

The present Special Issue will be addressed mainly, but not exclusively, to presenting the most recent results concerning new applications (nutraceutical, biological, pharmacological, etc.) of plant extracts, essential oils, and pure compounds isolated from plants; the description of previously unknown phytochemical profiles of plant species; and the structural elucidation of non-banal new molecules from plant extracts.

Prof. Dr. Maurizio Bruno
Guest Editor

Manuscript Submission Information

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Keywords

  • essential oils
  • plant extracts
  • bioactivity
  • new phytochemicals

Published Papers (2 papers)

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Research

11 pages, 1842 KiB  
Article
The Biological Properties of the Essential Oil from the Jordan Accession of Phagnalon sinaicum Bornm. & Kneuck.
by Natale Badalamenti, Michela Di Napoli, Giusy Castagliuolo, Mario Varcamonti, Maurizio Bruno and Anna Zanfardino
Plants 2023, 12(23), 4007; https://doi.org/10.3390/plants12234007 - 28 Nov 2023
Viewed by 662
Abstract
The genus Phagnalon Cass. (Asteraceae) is composed of widely distributed species and most of them, due to the medicinal properties they possess, are widely used in folk medicine but also as spices in the culinary field. The polar and non-polar extracts, as well [...] Read more.
The genus Phagnalon Cass. (Asteraceae) is composed of widely distributed species and most of them, due to the medicinal properties they possess, are widely used in folk medicine but also as spices in the culinary field. The polar and non-polar extracts, as well as the complex mixtures of their essential oils, from several Phagnalon species and ssp., have shown antibiotic, antiviral, cytotoxic, and several other biological properties. In this work, the chemical composition and the antimicrobial, cytotoxic, and antioxidant properties of the Jordan accession of Phagnalon sinaicum Bornm. & Kneuck. essential oil (EO), an extremely rare plant that grows in ravines in the Middle East, were investigated. The EO, analyzed by GC-MS, was found to be rich in terpenoid compounds, and, in particular, in oxygenated monoterpenes, with the main compound being artemisia ketone (22.3%), followed by α-thujone (17.7%), and santolin alcohol (14.8%). The EO had good antimicrobial activity, especially against Escherichia coli Gram-negative bacterium (3 mg/mL MIC values) and was also effective in counteracting in vitro biofilm formation. Furthermore, this EO showed low cytotoxicity against immortalized human keratinocytes lines, but had good antioxidant activity on the same eukaryotic cellular models. Full article
(This article belongs to the Special Issue Application and Chemical Characterization of Plant Natural Products)
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15 pages, 2146 KiB  
Article
Antioxidant Activity and Chemical Composition of Geranium Oil and Its Synergistic Potential against Pneumococci with Various Antibiotic Combinations
by Berrak Dumlupinar, Gökçe Şeker Karatoprak, Betül Demirci, Esra Küpeli Akkol and Eduardo Sobarzo-Sánchez
Plants 2023, 12(17), 3080; https://doi.org/10.3390/plants12173080 - 28 Aug 2023
Cited by 2 | Viewed by 1078
Abstract
The essential oil of Pelargonium graveolens L. is valuable for its therapeutic benefits, so this study aimed to determine the synergistic effect of the combination of the essential oil of this plant with antibiotics instead of the extracts prepared with various solvents. In [...] Read more.
The essential oil of Pelargonium graveolens L. is valuable for its therapeutic benefits, so this study aimed to determine the synergistic effect of the combination of the essential oil of this plant with antibiotics instead of the extracts prepared with various solvents. In addition, the second goal of this study was to determine whether the essential oil combined with various antibiotics increased the overall killing activity in mouse macrophage cells with the aim of introducing an immunotherapeutic approach to the infection treatments used today. Herein, the volatile profile of Geranium oil (G.O) was analyzed using GC/MS. The current study sought to assess the synergistic characteristics of several antibiotic combinations using G.O against pneumococci, as well as the oil’s antioxidant and antimicrobial activities. The major components of the oil were citronellol, geraniol, and isomenthone. In the combinations of G.O and antibiotics, the synergism of the Streptococcus pneumoniae to antibiotics advanced. When the time-kill data were evaluated, G.O + antibiotic combinations quickly diminished the viable cell count of S. pneumoniae from the 6th h. In this study, the combined use of existing antibiotics used in infection treatments with G.O could improve antibiotic effectiveness and thus prevent bacteria from developing antibiotic resistance. Full article
(This article belongs to the Special Issue Application and Chemical Characterization of Plant Natural Products)
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