Exploring the Antimicrobial Resistance Potential of Plant-Derived Compounds

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 1238

Special Issue Editors


E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano, 49, I-80131 Naples, Italy
Interests: natural product chemistry; chromatography; phytochemicals; natural product isolation; extraction; natural product drug discovery; compound isolation; NMR structure elucidation; mass spectrometry; metabolomics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, I-80131 Naples, Italy
Interests: phytochemistry; chromatography; antimalarial compounds; semi-synthetic natural products; extraction and isolation; natural product drug discovery; compound isolation; NMR structure elucidation; mass spectrometry; metabolomics

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit original research manuscripts, review articles or communications to the Special Issue titled “Exploring the Antimicrobial Resistance Potential of Plant-derived Compounds”.

In the field of public health, one of the present principal emergencies is antimicrobial resistance (AMR), which poses a significant global health threat. Since bacterial resistance to antimicrobials is mediated by a few core mechanisms, plant-derived natural products can play a crucial role in fighting multi-drug resistance because they can act as antibacterial agents through a variety of modes of action that target these resistant mechanisms and other pathways necessary for bacterial survival. Ongoing research in the phytochemistry field is imperative to identify, isolate, and characterize novel antimicrobial compounds from plants. In addition, modern techniques, such as metabolomics and bioinformatics, can aid in the discovery of promising candidates.

Specifically, we are interested in new research identifying the chemical structures and evaluating the antimicrobial potential of natural and semi-synthetic nature-inspired small molecules. Furthermore, as Guest Editors of this Special Issue, we encourage the submission of research papers describing the modern approaches of phytochemical analysis based on chemical dereplication, finger-printing, metabolomic studies and molecular networking. Comprehensive review papers that synthesize the current knowledge on this topic are also welcome.

Prof. Dr. Giuseppina Chianese
Dr. Carmina Sirignano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • secondary metabolites
  • metabolomics
  • NMR
  • extraction
  • structure elucidation
  • LC/MS
  • biological activity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

23 pages, 683 KiB  
Article
Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome
by Jennyfer A. Aldana-Mejía, Victor Pena Ribeiro, Kumar Katragunta, Bharathi Avula, Kiran Kumar Tatapudi, Jairo Kenupp Bastos, Ikhlas A. Khan, Kumudini Meepagala and Samir A. Ross
Plants 2024, 13(24), 3576; https://doi.org/10.3390/plants13243576 - 21 Dec 2024
Cited by 1 | Viewed by 803
Abstract
Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated [...] Read more.
Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects. Full article
Show Figures

Figure 1

Back to TopTop