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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antibody-Functionalized Nanomedicines for Targeted Therapy

edited by Pie Huda and

Craig A. Bell

submission deadline 30 Jun 2026 | Viewed by 54 | Submission Open

Keywords: antibody– drug conjugates; antibody fragments; nanomedicine; radiotherapy; RNA/DNA delivery systems; theranostics; immunotherapy; targeted drug delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Cell Death, Mitochondrial Metabolism and Cancer Immunotherapy

edited by

Guang Lei

submission deadline 30 Jun 2026 | Viewed by 52 | Submission Open

Keywords: regulated cell death; mitochondrial metabolism; cancer metabolism; cancer immunotherapy; tumor suppressor pathways

(This special issue belongs to the Section Pharmacology)

Pharmacological Targeting of Immune Checkpoints and Regulatory Pathways

edited by Monika Ducceschi and

Stefano Cavalieri

submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open

Keywords: immunotherapy; immune-regulatory pathways; cancer; precision medicine; mechanism of resistance; predictive biomarkers; patient selection; immune-related adverse events

(This special issue belongs to the Section Pharmacology)

Hormone Signaling in Cardioprotection and Regeneration

edited by

Polyxeni D. Mantzouratou

and

Domenico Cerullo

submission deadline 30 Jun 2026 | Viewed by 23 | Submission Open

Keywords: cardiac regeneration; cardiac repair; heart failure; myocardial cell proliferation; hormone signaling; thyroid hormone; polyploidization; cell cycle

(This special issue belongs to the Section Pharmacology)

Optimizing Immunotherapeutic Strategies for Hematologic Malignancies

edited by

Erin Alexis Dean

, Victoria S. Brown and Dina Khalaf

submission deadline 30 Jun 2026 | Viewed by 21 | Submission Open

Keywords: lymphoma; multiple myeloma; leukemia; CAR T-cell therapy; NK cell therapy; autologous; allogeneic; bridging therapy; vein-to-vein time; safety switch; bispecific antibodies

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Endometriosis

edited by

Jang-Kyung Park

, Dong Il Kim and

Soo-Hyun Sung

submission deadline 1 Jul 2026 | 4 articles | Viewed by 24290 | Submission Open

Keywords: endometriosis; pharmacotherapy; integrative medicine; herbal medicine herbal formulations; plant-based compounds; herbal extracts; pharmacopuncture; pelvic pain; infertility

(This special issue belongs to the Section Pharmacology)

Recent Advances in Cancer Diagnosis and Therapy

edited by

Adriana Grigoraș

and

Hsin-Sheng Yang

submission deadline 5 Jul 2026 | 5 articles | Viewed by 11581 | Submission Open

Keywords: early diagnosis; advanced therapy; biomarkers; immunohistochemistry; molecular diagnosis; metastasis; prognosis; targeted therapies; combination therapies; cancer pharmacology

(This special issue belongs to the Section Pharmacology)

Redox-Active Natural Compounds in Metabolic and Inflammatory Diseases: Pharmacological Potential and Limitations

edited by

Mateusz Mołoń

and

Sabina Galiniak

submission deadline 15 Jul 2026 | Viewed by 19 | Submission Open

Keywords: redox-active natural compounds; oxidative stress modulation; metabolic diseases; inflammation; antioxidant pharmacology; bioactive phytochemicals

(This special issue belongs to the Section Natural Products)

Pharmaceutical Excipients in Formulation Design and Drug Delivery: 2nd Edition

edited by

Beverley D. Glass

submission deadline 24 Jul 2026 | Viewed by 313 | Submission Open

Keywords: formulation; excipients labelling; adverse effects; inactive ingredients; stability; regulation and quality; safety

(This special issue belongs to the Section Pharmaceutical Technology)

G-Protein-Coupled Receptors as Therapeutic Targets for CNS Disorders

edited by

Fabio Del Bello

and Wilma Quaglia

submission deadline 24 Jul 2026 | Viewed by 152 | Submission Open

Keywords: GPCRs; CNS disorders; biased ligands; allosteric modulators; GPCR heteromers; multitarget ligands

(This special issue belongs to the Section Pharmacology)

Clinical Advances in the Neuropharmacological Treatment of Substance Use Disorders: 2nd Edition

edited by

Stefania Chiappini

submission deadline 25 Jul 2026 | 2 articles | Viewed by 6480 | Submission Open

Keywords: neuropharmacology; drug abuse; addiction; substance abuse

(This special issue belongs to the Section Pharmacology)

Advances in Hybrid Anticancer Drugs: Innovations and Therapeutic Potential

edited by

Dmytro Khylyuk

submission deadline 25 Jul 2026 | 3 articles | Viewed by 3701 | Submission Open

Keywords: drug design; molecular hybrids; anticancer agents; privileged scaffold; multiple mechanisms of action

(This special issue belongs to the Section Medicinal Chemistry)

Research Progress and Drug Intervention Strategies for Oral Health-Related Diseases

edited by

Claudia Florina Bogdan-Andreescu

and Mariana Pacurar

submission deadline 25 Jul 2026 | 1 articles | Viewed by 639 | Submission Open

Keywords: oral health; dental caries; periodontal diseases; drug intervention; biomaterials; biomarkers; microbiome; pharmacogenomics; targeted therapy; oral drug delivery; oral disease prevention

(This special issue belongs to the Section Pharmacology)

Therapeutic Drug Monitoring and Adverse Drug Reactions: 3rd Edition

edited by Engi Abd El Hady Algharably and

Ursula Gundert-Remy

submission deadline 25 Jul 2026 | Viewed by 59 | Submission Open

Keywords: therapeutic drug monitoring; adverse drug reactions; pharmacokinetics; personalized medicine; medication safety; pharmacogenomics; medication review; pharmacokinetic modeling

(This special issue belongs to the Section Pharmacology)

Drug Target Exploration and Drug Design & Development Based on Small Molecule: 2nd Edition

edited by

Marco Tutone

and

Giulia Culletta

submission deadline 25 Jul 2026 | Viewed by 59 | Submission Open

Keywords: small molecules; drug design and development; target exploration; anticancer drugs; anti-inflammatory drugs; neuromodulation; natural compounds; nutraceuticals; virtual screenings

(This special issue belongs to the Section Pharmacology)

Development of Biomaterials for Targeted and Localized Cancer Drug Release

edited by Precious O. Etinosa and

John David Obayemi

submission deadline 25 Jul 2026 | Viewed by 1 | Submission Open

Keywords: targeted delivery; localized drug release; controlled release kinetics; cancer biomaterials; injectable hydrogels; implantable depots; nanoparticles/microparticles; tumor microenvironment

(This special issue belongs to the Section Pharmaceutical Technology)

Hybrid and Chimeric Heterocycles: A Promising Approach to Synthesizing Biologically Active Compounds

edited by

Ionel Mangalagiu

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3743 | Submission Open

Keywords: hybrid heterocyclic compounds; chimeric heterocyclic compounds; multifactorial diseases; multiple targeting drugs; biological activity: antimicrobials; antiviral; anthelmintic; anti-HIV; anticancer; antiallergic; diuretics; cardiotonic; antihypertensive; antiplatelet; analgesic; anxiolytics; antidepressant; hypnotic sedative; antineurodegenerative; anti-Alzheimer’ s etc.

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacology and Toxicology of Opioids, 2nd Edition

edited by

Juliana Faria

, Joana Barbosa and

Ricardo Dinis-Oliveira

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2991 | Submission Open

Keywords: opioid toxicity; opioid pharmacodynamics; opioid pharmacokinetics; opioid pharmacogenetics; prescription opioids; toxicity assays; in vivo; in vitro; abuse; dependence

(This special issue belongs to the Section Pharmacology)

The Nuclear Factor Kappa-B (NF-κB) Pathway as a Target for Drug Discovery

edited by Guozhou Xu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 932 | Submission Open

Keywords: NF-kappaB; TNFR; TLR; IL1R; receptor adaptor proteins; IRAK; c-IAP; AKT IKK; ubiquitin– proteasome system; inflammatory response

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Medicinal Plants and Plant-Derived Compounds: Neuroprotective, Anti-Inflammatory, Antioxidant, Anticancer, and Antimicrobial Applications

edited by Isabel Martínez Solís,

Jose Ignacio Bueso-Bordils

and

Nuria Acero de Mesa

submission deadline 31 Jul 2026 | 1 articles | Viewed by 656 | Submission Open

Keywords: medicinal plants; bioactive compounds; neuroprotection; antioxidant activity; anti-inflammatory effects; anti-tumour properties; antimicrobial agents; phytotherapy; natural product-based therapeutics

(This special issue belongs to the Section Natural Products)

Peptide Synthesis and Drug Development: Exploring Progress and Potential, 2nd Edition

edited by

Othman Al Musaimi

and Vera D'Aloisio

submission deadline 31 Jul 2026 | Viewed by 124 | Submission Open

Keywords: peptides; enzymatic degradation; drug discovery; formulation; druggability

(This special issue belongs to the Section Biopharmaceuticals)

Treating Cognitive Deficits in Neuropsychiatric and Neurodegenerative Disorders: Mechanisms, Targets, and Translational Advances

edited by Kinga Sałaciak and Klaudia Lustyk

submission deadline 31 Jul 2026 | Viewed by 96 | Submission Open

Keywords: cognitive enhancement; cognitive impairment; molecular targets; neuropharmacology; neural plasticity; translational research; memory; executive function

(This special issue belongs to the Section Pharmacology)

Advanced Three-Dimensional In Vitro Models for Disease Biology and Pharmaceutical Development

edited by

Emilia Reszczyńska

submission deadline 31 Jul 2026 | Viewed by 73 | Submission Open

Keywords: 3D in vitro culture systems; extracellular matrix modeling; tumor microenvironment; cell– cell and cell– matrix interactions; invasiveness assays; biophysical characterization of cells; plant-based therapeutic agents

(This special issue belongs to the Section Medicinal Chemistry)

Supersaturated Formulations in Drug Development: From Solubility Investigations to the Advancement of In Vitro–In Vivo Predictability

edited by Réka Angi,

Tamas Solymosi

, Anna Vincze,

María Peña Fernández

and

Ziyaur Rahman

submission deadline 31 Jul 2026 | Viewed by 67 | Submission Open

Keywords: supersaturation; solubility assessment; dissolution mechanisms; advanced formulations; amorphous solid dispersion; nanoprecipitation; in vitro– in vivo prediction; absorption modelling; phase transitions

(This special issue belongs to the Section Pharmaceutical Technology)

Advances in GPCR Drug Discovery

edited by

Santo Previti

submission deadline 31 Jul 2026 | Viewed by 53 | Submission Open

Keywords: GPCR; agonists; antagonists; biased ligands; allosteric sites; drug discovery; pharmacological tools; diagnostic tools; theranostics; biodistribution

(This special issue belongs to the Section Biopharmaceuticals)

New Advances and Treatment in Thrombosis and Endothelial Injury Syndromes

edited by

Paschalis Evangelidis

and

Panagiota Anyfanti

submission deadline 31 Jul 2026 | Viewed by 30 | Submission Open

Keywords: antiphospholipid syndrome; autoimmune rheumatic diseases; cardiovascular disease; endothelial dysfunction; hematopoietic cell transplantation; thromboinflammation; thrombosis; thrombotic microangiopathies; venous thromboembolism

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases

edited by

Luzineide Tinoco

and

Pedro De Sena Murteira Pinheiro

submission deadline 28 Aug 2026 | 7 articles | Viewed by 17591 | Submission Open

Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure– activity relationship; preclinical evaluation

(This special issue belongs to the Section Medicinal Chemistry)

Plant-Based Extracts and the Therapeutic Potential of Bioactive Compounds, 2nd Edition

edited by

Grażyna Zgórka

submission deadline 31 Aug 2026 | 6 articles | Viewed by 8423 | Submission Open

Keywords: plant extracts; herbal medicinal products; standardization; phytochemical profiling; bioactive plant compounds; therapeutic effects

(This special issue belongs to the Section Natural Products)

Recent Advancements in the Development of Antiprotozoal Agents: 2nd Edition

edited by Francesco Saccoliti and Alessandro Giraudo

submission deadline 25 Sep 2026 | Viewed by 74 | Submission Open

Keywords: antiprotozoal; drug discovery; chemotherapy; parasite; protozoa; mechanism of antiprotozoal agents

(This special issue belongs to the Section Medicinal Chemistry)

Multi-Targeted Natural Products as Therapeutics, 2nd Edition

edited by

Elena Y. Enioutina

Catherine M. T. Sherwin

and

Kathleen M. Job

submission deadline 30 Sep 2026 | 1 articles | Viewed by 637 | Submission Open

Keywords: natural products; medicinal herbs; marine products; animal products; bioactive compounds; multifactorial diseases; multi-targeting phytochemicals

(This special issue belongs to the Section Natural Products)

Omics Approaches in Drug Discovery, Precision Therapy, and Disease Prevention

edited by

Antonia Efstathiou

and

Dimitra K. Toubanaki

submission deadline 30 Sep 2026 | Viewed by 68 | Submission Open

Keywords: omics technologies; multi-omics analysis; drug target discovery; biomarker discovery; vaccine target identification; translational therapeutics; genomics; transcriptomics; proteomics; metabolomics; pharmacogenomics

(This special issue belongs to the Section Medicinal Chemistry)

New Advances in Antiarrhythmic Drugs

edited by

Norbert Szentandrássy

submission deadline 20 Oct 2026 | 7 articles | Viewed by 20492 | Submission Open

Keywords: antiarrhythmic drugs; ion channel blockers; cardiac action potential; sudden cardiac death; cardiac arrhythmia; proarrhythmic action

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Thromboembolism

edited by

Matej Samoš

Tomáš Bolek

and

Marián Mokáň

submission deadline 25 Oct 2026 | 8 articles | Viewed by 24091 | Submission Open

Keywords: activated factor XI inhibitors; platelet glycoprotein VI antagonists; PAR4 antagonists; PI3K inhibitorslong-term anticoagulation; antiplatelet therapy; novel antithrombotic drugs; anticoagulation-related bleeding; post-vascular procedure-related thrombosis

(This special issue belongs to the Section Pharmacology)

New Structural, Biophysical and Computational Perspectives on the Use of Proteins in Drug Design and Discovery

edited by

Marino F. A. Santos

Luís Passarinha

and

João Paquete-Ferreira

submission deadline 31 Oct 2026 | Viewed by 163 | Submission Open

Keywords: artificial intelligence; bioinformatics; computational modelling; drug discovery and design; functional proteomics; mass spectrometry; molecular dynamics; protein– ligand interactions; structural proteomics; structural biology; target identification and validation

(This special issue belongs to the Section Biopharmaceuticals)

Displaying special issue 351-400 on page 8 of 8.

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