Special Issue "Functional Polymeric Nanoparticles"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 10 September 2020.

Special Issue Editor

Dr. Krzysztof Szczepanowicz
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Guest Editor
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences Niezapominajek 8, PL - 30239 Krakow, Poland
Interests: Nanomaterials, nanomedicine, polymeric nanoparticles, nanocapsules, drug delivery, targeted therapy, passive, active and physical targeting, theranostics, imaging, metallic nanoparticles, layer by layer, anticancer therapy, neurodegenerative disorders, physical chemistry, surface modification

Special Issue Information

Dear Colleagues,

Continued advancements in nanotechnology are expanding the boundaries of medical research, most notably as a drug delivery system for anticancer treatment. Application of nanotechnology in the delivery of therapeutic as well as imaging agents can offer greater control over their biodistribution, usually toxic compounds, to improve the therapeutic index. Controlling materials at the nanoscale offers the opportunity to develop medicines with precisely engineered functions in the body. The design of the majority of therapeutic and imaging agents delivery system hugely relies on nanoparticles. Because nanoparticles can exhibit high surface to volume ratios, unique optical properties, tunable shapes, and/or modifiable surfaces, they provide a mechanism for controlling the transport of various therapeutic cargo, within the body, both temporally and spatially.

The application of nanoscale materials in medicine, generally termed nanomedicine, has become mainstream. Nanomedicine is a field of research with huge expectations for the development of personalized medicine based on new nanoparticles. The use of nanoparticles in targeted drug delivery may overcome many intractable health challenges.

We invite researchers to contribute original and review articles regarding the functional polymeric nanoparticles. Potential topics include, but are not limited to: synthesis, modification, and functionalization of nanoparticles, encapsulation of actives, nanoparticles’ characterization and characterization methods, application of nanoparticles as drug carriers, targeted drug delivery systems, passive, active and physical targeting theranostics, formulating new nanomaterials, in vitro and in vivo studies on nanoparticulate systems.

Dr. Krzysztof Szczepanowicz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanomaterials
  • nanomedicine
  • polymeric nanoparticles
  • drug delivery
  • targeted therapy
  • passive
  • active and physical targeting
  • theranostics
  • imaging
  • functionalization

Published Papers (1 paper)

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Research

Open AccessArticle
Polymeric Core-Shell Nanoparticles Prepared by Spontaneous Emulsification Solvent Evaporation and Functionalized by the Layer-by-Layer Method
Nanomaterials 2020, 10(3), 496; https://doi.org/10.3390/nano10030496 - 10 Mar 2020
Abstract
The aim of our study was to develop a novel method for the preparation of polymeric core-shell nanoparticles loaded with various actives for biomedical applications. Poly(caprolactone) (PCL), poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared using the spontaneous emulsification solvent evaporation (SESE) [...] Read more.
The aim of our study was to develop a novel method for the preparation of polymeric core-shell nanoparticles loaded with various actives for biomedical applications. Poly(caprolactone) (PCL), poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared using the spontaneous emulsification solvent evaporation (SESE) method. The model active substance, Coumarin-6, was encapsulated into formed polymeric nanoparticles, then they were modified/functionalized by multilayer shells’ formation. Three types of multilayered shells were formed: two types of polyelectrolyte shell composed of biocompatible and biodegradable polyelectrolytes poly-L-lysine hydrobromide (PLL), fluorescently-labeled poly-L-lysine (PLL-ROD), poly-L-glutamic acid sodium salt (PGA) and pegylated-PGA (PGA-g-PEG), and hybrid shell composed of PLL, PGA, and SPIONs (superparamagnetic iron oxide nanoparticles) were used. Multilayer shells were constructed by the saturation technique of the layer-by-layer (LbL) method. Properties of our polymeric core-shell nanoparticle were optimized for bioimaging, passive and magnetic targeting. Full article
(This article belongs to the Special Issue Functional Polymeric Nanoparticles)
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