Recent Advances in the Construction and Applications of Nanozymes

Dear Colleagues,

Biological enzymes are macromolecular-sized catalysts that catalyze biochemical reactions. Although each enzyme performs a particular function, it holds several drawbacks, limiting its utilization in broad-spectrum applications. Therefore, as an alternative, several synthetic strategies have been introduced to formulate novel types of enzymes that can mimic intrinsic enzymatic properties and overcome the limitations of natural enzymes. The new generation of nanoparticle-based artificial enzymes (nanoenzymes) has gained recognition as surrogates for natural enzymes owing to their physicochemical attributes and advantages, including low-cost and straightforward synthesis methods, high stability, robust catalytic performance, and ease of surface modification. Seeing these advantages of nanozymes, a rapid expansion of the development of artificial biocatalysts is much needed. However, nanozymes have already found multidisciplinary applications in a wide range of applications in biosensing, immunoassays, disease diagnosis and therapy, theranostics, cell/tissue growth, protection from oxidative stress, and removal of pollutants. This Special Issue will comprehensively highlight the scientific and commercial value of nanozymes, mainly in the field of cancer diagnosis, imaging, and treatments, as well as the study of the enzyme-like properties (such as peroxidase, catalase, superoxide dismutase, and oxidase), exhibited by various metal nanoparticles. We cordially invite authors to contribute either research articles or reviews, or short communication to this emerging area of nanozymes.

Special Issue Research areas may include (but are not limited to) the following areas.

• Synthetic strategies and applications of various enzyme-mimicking nanomaterials.
• Precise tailoring of the enzymatic activities of nanozymes.
• Mechanistic insights of nanozymes.
• Study of nanoenzyme properties.
• Peroxidase, catalase, superoxide dismutase, and oxidase.
• Nanozyme applications for cancer diagnostics, therapeutics, and theranostics.

We are looking forward to receiving your contributions.

Dr. Prakash Kshirsagar
Dr. Valeria De Matteis
Dr. Sudipto Pal
Guest Editors

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