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Nanomaterials
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Recent Advances in Cancer Nanotechnology
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Recent Advances in Cancer Nanotechnology

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 5895

Special Issue Editors

Dr. Devika Chithrani

E-Mail Website
Guest Editor
Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Road, Elliott Building, Room 101, Victoria, BC V8P 5C2, Canada
Interests: cancer nanotechnology; drug delivery; radiotherapy; chemotherapy; tissue engineering
Dr. Gopinath Packirisamy

E-Mail Website
Guest Editor
Indian Institute of Technology, Roorkee Department of Biotechnology, Centre for Nanotechnology, India
Interests: biomedical nanotechnology; drug delivery; bioimaging; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanotechnology is playing a vital role in improving current cancer therapeutics. The highly tunable physical and optical properties and the ability to bind an ever-expanding library of ligands have catapulted nanoparticles into current cancer research. As nanoparticles inch closer to being fully deployed at the clinical level, some of the recent advances in the applications of nanoparticles in cancer nanomedicine will be discussed in this Special Issue. From imaging and diagnostics to therapy and treatment, a variety of nanoparticles are presented along with their physical and optical properties to be used in a diverse array of medical applications. This Special Issue aims to offer a more widespread view on visualization, diagnosis and treatment of disease with various types of nanoparticles.

Dr. Devika Chithrani
Dr. Gopinath Packirisamy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • drug delivery
  • imaging
  • radiotherapy
  • photothermal therapy
  • photodynamic therapy
  • chemotherapy

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Published Papers (2 papers)

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Research

23 pages, 8714 KiB  
Article
Combinatorial Delivery of Gallium (III) Nitrate and Curcumin Complex-Loaded Hollow Mesoporous Silica Nanoparticles for Breast Cancer Treatment
by Thimma Mohan Viswanathan, Vaithilingam Krishnakumar, Dharmaraj Senthilkumar, Kaniraja Chitradevi, Ramakrishnan Vijayabhaskar, Velu Rajesh Kannan, Nachimuthu Senthil Kumar, Krishnan Sundar, Selvaraj Kunjiappan, Ewa Babkiewicz, Piotr Maszczyk and Thandavarayan Kathiresan
Nanomaterials 2022, 12(9), 1472; https://doi.org/10.3390/nano12091472 - 26 Apr 2022
Cited by 17 | Viewed by 3666
Abstract
The main aims in the development of a novel drug delivery vehicle is to efficiently carry therapeutic drugs in the body’s circulatory system and successfully deliver them to the targeted site as needed to safely achieve the desired therapeutic effect. In the present [...] Read more.
The main aims in the development of a novel drug delivery vehicle is to efficiently carry therapeutic drugs in the body’s circulatory system and successfully deliver them to the targeted site as needed to safely achieve the desired therapeutic effect. In the present study, a passive targeted functionalised nanocarrier was fabricated or wrapped the hollow mesoporous silica nanoparticles with 3-aminopropyl triethoxysilane (APTES) to prepare APTES-coated hollow mesoporous silica nanoparticles (HMSNAP). A nitrogen sorption analysis confirmed that the shape of hysteresis loops is altered, and subsequently the pore volume and pore diameters of GaC-HMSNAP was reduced by around 56 and 37%, respectively, when compared with HMSNAP. The physico-chemical characterisation studies of fabricated HMSNAP, Ga-HMSNAP and GaC-HMSNAP have confirmed their stability. The drug release capacity of the fabricated Ga-HMSNAP and GaC-HMSNAP for delivery of gallium and curcumin was evaluated in the phosphate buffered saline (pH 3.0, 6.0 and 7.4). In an in silico molecular docking study of the gallium-curcumin complex in PDI, calnexin, HSP60, PDK, caspase 9, Akt1 and PTEN were found to be strong binding. In vitro antitumor activity of both Ga-HMSNAP and GaC-HMSNAP treated MCF-7 cells was investigated in a dose and time-dependent manner. The IC50 values of GaC-HMSNAP (25 µM) were significantly reduced when compared with free gallium concentration (40 µM). The mechanism of gallium-mediated apoptosis was analyzed through western blotting and GaC-HMSNAP has increased caspases 9, 6, cleaved caspase 6, PARP, and GSK 3β(S9) in MCF-7 cells. Similarly, GaC-HMSNAP is reduced mitochondrial proteins such as prohibitin1, HSP60, and SOD1. The phosphorylation of oncogenic proteins such as Akt (S473), c-Raf (S249) PDK1 (S241) and induced cell death in MCF-7 cells. Furthermore, the findings revealed that Ga-HMSNAP and GaC-HMSNAP provide a controlled release of loaded gallium, curcumin and their complex. Altogether, our results depicted that GaC-HMNSAP induced cell death through the mitochondrial intrinsic cell death pathway, which could lead to novel therapeutic strategies for breast adenocarcinoma therapy. Full article
(This article belongs to the Special Issue Recent Advances in Cancer Nanotechnology)
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15 pages, 1282 KiB  
Article
Design, Synthesis, and Cytotoxicity Assessment of [64Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker
by Meysam Khosravifarsani, Samia Ait-Mohand, Benoit Paquette, Léon Sanche and Brigitte Guérin
Nanomaterials 2021, 11(9), 2154; https://doi.org/10.3390/nano11092154 - 24 Aug 2021
Cited by 14 | Viewed by 3719
Abstract
Maximum benefits of chemoradiation therapy with platinum-based compounds are expected if the radiation and the drug are localized simultaneously in cancer cells. To optimize this concomitant effect, we developed the novel chemoradiotherapeutic agent [64Cu]Cu-NOTA-C3-TP by conjugating, via a short flexible alkyl [...] Read more.
Maximum benefits of chemoradiation therapy with platinum-based compounds are expected if the radiation and the drug are localized simultaneously in cancer cells. To optimize this concomitant effect, we developed the novel chemoradiotherapeutic agent [64Cu]Cu-NOTA-C3-TP by conjugating, via a short flexible alkyl chain spacer (C3), a terpyridine platinum (TP) moiety to a NOTA chelator complexed with copper-64 (64Cu). The decay of 64Cu produces numerous low-energy electrons, enabling the 64Cu-conjugate to deliver radiation energy close to TP, which intercalates into G-quadruplex DNA. Accordingly, the in vitro internalization kinetic and the cytotoxic activity of [64Cu]Cu-NOTA-C3-TP and its derivatives were investigated with colorectal cancer (HCT116) and normal human fibroblast (GM05757) cells. Radiolabeling by 64Cu results in a >55,000-fold increase of cytotoxic potential relative to [NatCu]Cu-NOTA-C3-TP at 72 h post administration, indicating a large additive effect between 64Cu and the TP drug. The internalization and nucleus accumulation of [64Cu]Cu-NOTA-C3-TP in the HCT116 cells were, respectively, 3.1 and 6.0 times higher than that for GM05757 normal human fibroblasts, which is supportive of the higher efficiency of the [64Cu]Cu-NOTA-C3-TP for HCT116 cancer cells. This work presents the first proof-of-concept study showing the potential use of the [64Cu]Cu-NOTA-C3-TP conjugate as a targeted chemoradiotherapeutic agent to treat colorectal cancer. Full article
(This article belongs to the Special Issue Recent Advances in Cancer Nanotechnology)
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