Biomimetic and Biogenic Multifunctional Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 4638

Special Issue Editors

Department of Micro and Nanoelectronics, Saint Petersburg Electrotechnical University “LETI”, 197022 Saint Petersburg, Russia
Interests: magnetic composites; radio-wave absorbing materials; electromagnetic measurements; sol–gel; nanomaterials; theranostics; superparamagnetism; magnetic nanoparticles; biomineralization; magnetosomes; continuous flow synthesis
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Guest Editor
Center of Translational Cancer Research (TranslaTUM), Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany
Interests: superparamagnetic iron oxide nanoparticles; nanoparticle therapy; molecular layering; heat-shock proteins; theranostics; immunotherapy; biomarkers; monoclonal antibodies; biosensors; biodistribution; nanotubes; tissue engineering

Special Issue Information

Dear Colleagues,

This Special Issue is devoted to an important direction in the development of new magnetic and nonmagnetic nanomaterials associated with the use of natural, namely biogenic, components in their composition or in their preparation, as well as with the imitation of natural processes in the synthesis of biomimetic nanomaterials. The use of biogenic nanomaterials, including bacterial metallic and semiconductor nanoparticles, and magnetosomes provides high physicochemical and biological characteristics that are not always achievable for fully synthetic nanomaterials. At the same time, the productivity of biomineralization processes is still inferior to the productivity of modern synthesis techniques, including the bioinspired methods for obtaining colloidal quantum dots, noble metal nanoparticles and magnetic liposomes. In addition, the imitation of natural processes in the preparation of magnetic nanomaterials makes it possible to significantly simplify paleomagnetic studies of magnetic minerals, including those containing biogenic nanosized inclusions of iron oxides of various polymorphic modifications. Finally, new biogenic, biomimetic and hybrid natural-synthetic nanomaterials for a full understanding of the processes occurring during their synthesis and subsequent application make developing new research methods relevant, including instrumental techniques and mathematical modeling.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Biogenic magnetic and nonmagnetic nanomaterials;
  • Biomimetic magnetic and nonmagnetic nanomaterials;
  • Hybrid natural-synthetic nanomaterials;
  • Natural minerals containing biogenic nanoparticles and their synthetic analogues;
  • Nanostructured composite membranes for biomimetic actuators and sensors;
  • Sustainable multifunctional biomimetic nanomaterials;
  • Bioinspired synthesis of nanomaterials;
  • Novel methods for study of biomimetic and biogenic nanomaterials;
  • Mathematical modeling of biomimetic and biogenic nanomaterials;
  • Applications of biomimetic and biogenic nanomaterials.

We look forward to receiving your contributions.

Dr. Kamil Gareev
Dr. Maxim Shevtsov
Guest Editors

Manuscript Submission Information

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Keywords

  • biomimetics
  • biomineralization
  • sustainability
  • multifunctional nanomaterials
  • nanoparticles
  • magnetic liposomes
  • magnetosomes
  • biomimetic actuators and sensors
  • mathematical modeling
  • bioinspired synthesis

Published Papers (2 papers)

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Research

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20 pages, 3284 KiB  
Article
Liposomal Form of 2,4-Dinitrophenol Lipophilic Derivatives as a Promising Therapeutic Agent for ATP Synthesis Inhibition
by Kseniya Yu. Vlasova, Petr Ostroverkhov, Daria Vedenyapina, Tamara Yakimova, Alla Trusova, Galina Yurievna Lomakina, Stepan Sergeevich Vodopyanov, Mikhail Grin, Natalia Klyachko, Vladimir Chekhonin and Maxim Abakumov
Nanomaterials 2022, 12(13), 2162; https://doi.org/10.3390/nano12132162 - 23 Jun 2022
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Abstract
Mitochondrial uncoupler 2,4-dinitrophenol (2,4-DNP) is a promising antidiabetic and antiobesity agent. Its clinical use is limited by a narrow dynamic range and accumulation in non-target sensitive organs, which results in whole-body toxicity. A liposomal formulation could enable the mentioned drawbacks to be overcome [...] Read more.
Mitochondrial uncoupler 2,4-dinitrophenol (2,4-DNP) is a promising antidiabetic and antiobesity agent. Its clinical use is limited by a narrow dynamic range and accumulation in non-target sensitive organs, which results in whole-body toxicity. A liposomal formulation could enable the mentioned drawbacks to be overcome and simplify the liver-targeted delivery and sustained release of 2,4-DNP. We synthesized 2,4-DNP esters with carboxylic acids of various lipophilic degrees using carboxylic acid chloride and then loaded them into liposomes. We demonstrated the effective increase in the entrapment of 2,4-DNP into liposomes when esters were used. Here, we examined the dependence of the sustained release of 2,4-DNP from liposomes on the lipid composition and LogPoct of the ester. We posit that the optimal chain length of the ester should be close to the palmitic acid and the lipid membrane should be composed of phospholipids with a certain phase transition point depending on the desired release rate. The increased effect of the ATP synthesis inhibition of the liposomal forms of caproic and palmitic acid esters compared to free molecules in liver hepatocytes was demonstrated. The liposomes’ stability could well be responsible for this result. This work demonstrates promising possibilities for the liver-targeted delivery of the 2,4-DNP esters with carboxylic acids loaded into liposomes for ATP synthesis inhibition. Full article
(This article belongs to the Special Issue Biomimetic and Biogenic Multifunctional Nanomaterials)
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Review

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30 pages, 8293 KiB  
Review
Biomimetic Nanomaterials: Diversity, Technology, and Biomedical Applications
by Kamil G. Gareev, Denis S. Grouzdev, Veronika V. Koziaeva, Nikita O. Sitkov, Huile Gao, Tatiana M. Zimina and Maxim Shevtsov
Nanomaterials 2022, 12(14), 2485; https://doi.org/10.3390/nano12142485 - 20 Jul 2022
Cited by 18 | Viewed by 3794
Abstract
Biomimetic nanomaterials (BNMs) are functional materials containing nanoscale components and having structural and technological similarities to natural (biogenic) prototypes. Despite the fact that biomimetic approaches in materials technology have been used since the second half of the 20th century, BNMs are still at [...] Read more.
Biomimetic nanomaterials (BNMs) are functional materials containing nanoscale components and having structural and technological similarities to natural (biogenic) prototypes. Despite the fact that biomimetic approaches in materials technology have been used since the second half of the 20th century, BNMs are still at the forefront of materials science. This review considered a general classification of such nanomaterials according to the characteristic features of natural analogues that are reproduced in the preparation of BNMs, including biomimetic structure, biomimetic synthesis, and the inclusion of biogenic components. BNMs containing magnetic, metal, or metal oxide organic and ceramic structural elements (including their various combinations) were considered separately. The BNMs under consideration were analyzed according to the declared areas of application, which included tooth and bone reconstruction, magnetic and infrared hyperthermia, chemo- and immunotherapy, the development of new drugs for targeted therapy, antibacterial and anti-inflammatory therapy, and bioimaging. In conclusion, the authors’ point of view is given about the prospects for the development of this scientific area associated with the use of native, genetically modified, or completely artificial phospholipid membranes, which allow combining the physicochemical and biological properties of biogenic prototypes with high biocompatibility, economic availability, and scalability of fully synthetic nanomaterials. Full article
(This article belongs to the Special Issue Biomimetic and Biogenic Multifunctional Nanomaterials)
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