Special Issue "Functionalized Porous Silica-Based Nanoparticles: From Synthesis to Applications"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (10 March 2019)

Special Issue Editor

Guest Editor
Dr. Elena Aznar

CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) and Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camino de Vera s/n 46022, Valencia (Spain)
Website 1 | Website 2 | E-Mail
Interests: functional mesoporous materials; controlled release applications; nanotherapies; nanodiagnostics; smart nanomaterials

Special Issue Information

Dear Colleagues,

Porous silica-based nanoparticles are one of the most commonly-used supports to prepare functional nanomaterials. In general, these materials are synthesized using a self-assembly strategy based on the hydrolysis of an inorganic precursor around a pre-organized organic template such as surfactant micelles or block copolymers. The obtained supports can be easily chemically-modified as silicon oxide functionalization chemistry has been widely studied. At present, it is possible to modulate density, distribution, or even the location of the incorporated functional groups. Decoration of these materials with molecules, super-molecules or even with other inorganic materials confers new advantageous features to the final material, which find application in many fields, such as controlled release, molecular and biomolecular recognition, imaging, self-healing, remediation, catalysis or biomaterials among others. The present Special Issue is focused on the preparation and applications of new functional hybrid silica-based nanomaterials. This is a timely topic of research and an increasing interest in this kind of nanomaterials is envisioned due to their potential broad application in many fields.

Dr. Elena Aznar
Guest Editor

Manuscript Submission Information

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Keywords

  • Functional porous materials
  • Silica
  • Nanoparticles
  • Porous silica-based nanoparticles and controlled release
  • Porous silica-based nanoparticles and biomedical applications
  • Porous silica-based nanoparticles and self-healing
  • Porous silica-based nanoparticles and remediation
  • Porous silica-based nanoparticles and catalysis

Published Papers (6 papers)

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Research

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Open AccessArticle
Hybrid Mesoporous Nanoparticles for pH-Actuated Controlled Release
Nanomaterials 2019, 9(3), 483; https://doi.org/10.3390/nano9030483
Received: 11 March 2019 / Revised: 18 March 2019 / Accepted: 21 March 2019 / Published: 26 March 2019
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Abstract
Among a variety of inorganic-based nanomaterials, mesoporous silica nanoparticles (MSNs) have several attractive features for application as a delivery system, due to their high surface areas, large pore volumes, uniform and tunable pore sizes, high mechanical stability, and a great diversity of surface [...] Read more.
Among a variety of inorganic-based nanomaterials, mesoporous silica nanoparticles (MSNs) have several attractive features for application as a delivery system, due to their high surface areas, large pore volumes, uniform and tunable pore sizes, high mechanical stability, and a great diversity of surface functionalization options. We developed novel hybrid MSNs composed of a mesoporous silica nanostructure core and a pH-responsive polymer shell. The polymer shell was prepared by RAFT polymerization of 2-(diisopropylamino)ethyl methacrylate (pKa ~6.5), using a hybrid grafting approach. The hybrid nanoparticles have diameters of ca. 100 nm at pH < 6.5 and ca. 60 nm at pH > 6.5. An excellent control of cargo release is achieved by the combined effect of electrostatic interaction of the cargo with the charged silica and the extended cationic polymer chains at low pH, and the reduction of electrostatic attraction with a simultaneous collapse of the polymer chains to a globular conformation at higher pH. The system presents a very low (almost null) release rate at acidic pH values and a large release rate at basic pH, resulting from the squeezing-out effect of the coil-to-globule transition in the polymer shell. Full article
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Open AccessArticle
A Study of Catalytic Oxidation of a Library of C2 to C4 Alcohols in the Presence of Nanogold
Nanomaterials 2019, 9(3), 442; https://doi.org/10.3390/nano9030442
Received: 26 January 2019 / Revised: 9 March 2019 / Accepted: 12 March 2019 / Published: 15 March 2019
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Abstract
The classical stoichiometric oxidation of alcohols is an important tool in contemporary organic chemistry. However, it still requires huge modifications in order to comply with the principles of green chemistry. The use of toxic chemicals, hazardous organic solvents, and the large amounts of [...] Read more.
The classical stoichiometric oxidation of alcohols is an important tool in contemporary organic chemistry. However, it still requires huge modifications in order to comply with the principles of green chemistry. The use of toxic chemicals, hazardous organic solvents, and the large amounts of toxic wastes that result from the reactions are a few examples of the problems that must be solved. Nanogold alone or conjugated with palladium were supported on different carriers (SiO2, C) and investigated in order to evaluate their catalytic potential for environmentally friendly alcohol oxidation under solvent-free and base-free conditions in the presence H2O2 as a clean oxidant. We tested different levels of Au loading (0.1–1.2% wt.) and different active catalytic site forms (monometallic Au or bimetallic Au–Pd sites). This provided new insights on how the structure of the Au-dispersions affected their catalytic performance. Importantly, the examination of the catalytic performance of the resulting catalysts was oriented toward a broad scope of alcohols, including those that are the most resistant to oxidation—the primary aliphatic alcohols. Surprisingly, the studies proved that Au/SiO2 at a level of Au loading as low as 0.1% wt. appeared to be efficient and prospective catalytic system for the green oxidation of alcohol. Most importantly, the results revealed that 0.1% Au/SiO2 might be the catalyst of choice with a wide scope of utility in the green oxidation of various structurally different alcohols as well as the non-activated aliphatic ones. Full article
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Open AccessArticle
Tailored Synthesis of Core-Shell Mesoporous Silica Particles—Optimization of Dye Sorption Properties
Nanomaterials 2018, 8(4), 230; https://doi.org/10.3390/nano8040230
Received: 19 March 2018 / Revised: 30 March 2018 / Accepted: 5 April 2018 / Published: 10 April 2018
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Abstract
Monodisperse spherical silica particles, with solid cores and mesoporous shells (SCMS), were synthesized at various temperatures using a one-pot method utilizing a cationic surfactant template. The temperature of the synthesis was found to significantly affect the diameters of both the cores (ca. 170–800 [...] Read more.
Monodisperse spherical silica particles, with solid cores and mesoporous shells (SCMS), were synthesized at various temperatures using a one-pot method utilizing a cationic surfactant template. The temperature of the synthesis was found to significantly affect the diameters of both the cores (ca. 170–800 nm) and shells (ca. 11–80 nm) of the particles, which can be tailored for specific applications that require a high specific surface area of the nanocarriers (mesoporous shells) and simultaneously their mechanical robustness for, e.g., facile isolation from suspensions (dense cores). The applied method enabled the formation of the relatively thick mesoporous shells at conditions below room temperature. Radially ordered pores with narrow distributions of their sizes in 3–4 nm range were found in the shells. The adsorption ability of the SCMS particles was studied using rhodamine 6G as a model dye. Decolorization of the dye solution in the presence of the SCMS particles was correlated with their structure and specific surface area and reached its maximum for the particles synthesized at 15 °C. The presented strategy may be applied for the fine-tuning of the structure of SCMS particles and the enhancement of their adsorption capabilities. Full article
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Review

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Open AccessReview
Recent Studies on Fluorinated Silica Nanometer-Sized Particles
Nanomaterials 2019, 9(5), 684; https://doi.org/10.3390/nano9050684
Received: 9 April 2019 / Revised: 18 April 2019 / Accepted: 23 April 2019 / Published: 2 May 2019
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Abstract
Since initially being reported, fluorinated silica nanometer-sized particles (F-SiNPs) have gained much interest in the scientific community, due to their unique properties. These properties, include, low surface energies, increased mechanical strength, thermal robustness, and chemical resistance, and are a direct result of the [...] Read more.
Since initially being reported, fluorinated silica nanometer-sized particles (F-SiNPs) have gained much interest in the scientific community, due to their unique properties. These properties, include, low surface energies, increased mechanical strength, thermal robustness, and chemical resistance, and are a direct result of the incorporation of fluorine with a nanometer-sized silica network. This review aims to summarize the synthetic methods that have, and are still, being utilized to prepare these specialized materials. Following this, applications for F-SiNPs, with an emphasis on recent examples, will be presented in further detail. Full article
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Open AccessReview
Smart Mesoporous Silica Nanoparticles for Protein Delivery
Nanomaterials 2019, 9(4), 511; https://doi.org/10.3390/nano9040511
Received: 10 March 2019 / Revised: 20 March 2019 / Accepted: 23 March 2019 / Published: 2 April 2019
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Abstract
Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting [...] Read more.
Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting the loading of protein into MSN and general strategies for targeted delivery and controlled release of proteins with MSN. Additionally, we also give an outlook for the remaining challenges in the clinical translation of protein-loaded MSNs. Full article
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Open AccessReview
Functionalized Porous Silica-Based Nano/Micro Particles for Environmental Remediation of Hazard Ions
Nanomaterials 2019, 9(2), 247; https://doi.org/10.3390/nano9020247
Received: 15 January 2019 / Revised: 1 February 2019 / Accepted: 2 February 2019 / Published: 12 February 2019
Cited by 1 | PDF Full-text (5399 KB) | HTML Full-text | XML Full-text
Abstract
The adsorption and separation of hazard metal ions, radioactive nuclides, or minor actinides from wastewater and high-level radioactive waste liquids using functional silica-based nano/micro-particles modified with various inorganic materials or organic groups, has attracted significant attention since the discovery of ordered mesoporous silica-based [...] Read more.
The adsorption and separation of hazard metal ions, radioactive nuclides, or minor actinides from wastewater and high-level radioactive waste liquids using functional silica-based nano/micro-particles modified with various inorganic materials or organic groups, has attracted significant attention since the discovery of ordered mesoporous silica-based substrates. Focusing on inorganic and organic modified materials, the synthesis methods and sorption performances for specific ions in aqueous solutions are summarized in this review. Three modification methods for silica-based particles, the direct synthesis method, wetness impregnation method, and layer-by-layer (LBL) deposition, are usually adopted to load inorganic material onto silica-based particles, while the wetness impregnation method is currently used for the preparation of functional silica-based particles modified with organic groups. Generally, the specific synthesis method is employed based on the properties of the loading materials and the silicon-based substrate. Adsorption of specific toxic ions onto modified silica-based particles depends on the properties of the loaded material. The silicon matrix only changes the thermodynamic and mechanical properties of the material, such as the abrasive resistance, dispersibility, and radiation resistance. In this paper, inorganic loads, such as metal phosphates, molybdophosphate, titanate-based materials, and hydrotalcite, in addition to organic loads, such as 1,3-[(2,4-diethylheptylethoxy)oxy]-2,4-crown-6-Calix{4}arene (Calix {4}) arene-R14 and functional 2,6-bis-(5,6-dialkyl-1,2,4-triazin-3-yl)-pyridines(BTP) are reviewed. More specifically, we emphasize on the synthesis methods of such materials, their structures in relation to their capacities, their selectivities for trapping specific ions from either single or multi-component aqueous solutions, and the possible retention mechanisms. Potential candidates for remediation uses are selected based on their sorption capacities and distribution coefficients for target cations and the pH window for an optimum cation capture. Full article
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