Special Issue "Immune Responses to Nanomaterials for Biomedical Applications"
Deadline for manuscript submissions: 15 October 2020.
Interests: Innate immune system; chemokines; nanomaterials; nanobiointeractions; adjuvants
Special Issues and Collections in MDPI journals
Nanotechnology has consolidated its success in the past years by producing novel devices and materials, which are currently applied in several fields of research and industry. Our interest is focused on biomedical applications of nanotechnologies to improve the therapeutics’ performances, as well as diagnostics. Successful nanodevices for drug or gene delivery, imaging or synthesized with materials acting per se (e.g., nanozimes) require full biocompatibility. Recent literature has highlighted the importance of host immune responses to nanomaterials as a critical issue to be addressed in order to create safe-by-design nanotools.
The present Special Issue would like to overcome the “classical nanotoxicology” as limited to toxicity results on cell death mechanisms, rather providing information on the several interactions that the immune system has with nanomaterials developed to biomedical applications. Novel results on immune cell, tissue or different animal models’ inflammatory responses to nanomaterials will be welcome, as well as critical review articles challenging the present knowledge and offering an expert platform to discussion.
Dr. Giuseppe Bardi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- biomedical applications
- innate immune system
- adaptive immune system
- immune responses
- immune cells
- immune response
- inflammatory mediators
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions
Authors: Marina S. Dukhinova 1, Artur. Y. Prilepskii 1, Alexander A. Shtil 1,2, Vladimir V. Vinogradov 1,*
1 ITMO University, Saint-Petersburg, Russian Federation
2 Blokhin National Medical Center of Oncology, Moscow, Russian Federation
Correspondence: [email protected]
Abstract: Macrophages (MΦ) are the components of the innate immune system that control a plethora
of biological processes. In response to the cues such as bacterial pathogens, MΦ can be activated towards pro-inflammatory (M1) or anti-inflammatory (M2) phenotype upon the request; however, the polarization process is often misshaped in pathologies such as in cancer or autoimmune conditions. Metal oxide nanoparticles (zinc, iron, titanium, copper, etc.) are widely used in therapeutic applications as drugs, nanocarriers, and diagnostic tools. It is known that MΦs can recognize and phagocyte nanoparticles, while the influence of MΦ-nanoparticle interaction on MΦ polarization remains unclear. In this review, we summarize the primary molecular mechanisms that drive MΦs activation phenotypes and functions in vitro and in vivo models of pathological inflammation. Also, a brief overview of metal oxide nanoparticles synthesis procedures is outlined. While often seen as simple drug transporters, metal oxide nanoparticles themselves have immunotherapeutic potential, as nanoparticles can have pro- or anti-inflammatory effect on MΦs and become essential instruments of MΦ profiling in cancer, wounds, viral and bacterial infections, and autoimmunity. MΦ-nanoparticle interactions require further investigations for precise therapeutic control and novel targets in immune-related disorders.
Keywords: metal oxide nanoparticles; macrophages; inflammation; immunotherapy
Title: Metal oxide nanoparticles enhance Toll-like receptors in vitro
Authors: Koshel E, Fakhardo A., Vasilichin V, Tsyimbal S, Anastasova E., Shtil A, Vinogradov V. *
ITMO University, Saint-Petersburg, Russian Federation
Correspondence: [email protected]
Abstract: For the widespread application of nanotechnology in biomedicine, it is necessary to obtain
information about their safety. A critical problem is host immune responses to nanomaterials. It is suggested that the innate immune system is important for the interaction between cells and nanomaterials. However, there is only fragmentary data on the innate immune system activation by some nanoparticles (NPs). In this study, we investigated Toll-like receptors activation by clinically relevant and promising NPs such as Fe3O4, TiO2, ZnO, CuO, Ag2O and AlOOH. Cytotoxicity and effects on innate immunity factors were studied in THP-1 cell culture. NPs caused an increase in the expression of Toll-like receptors 4 and 6 to varying degrees. This suggests that the studied NPs can stimulate the innate immune system response inside the host. The data obtained should be taken into account in future research and to create safe-by-design biomedical nanomaterials.