Special Issue "Immune Responses to Nanomaterials for Biomedical Applications"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 15 November 2019

Special Issue Editor

Guest Editor
Dr. Giuseppe Bardi

Istituto Italiano di Tecnologia, Genoa, Italy
Website | E-Mail
Interests: nanobiointeractions; immune system; inflammation; nanoparticles

Special Issue Information

Dear Colleagues,

Nanotechnology has consolidated its success in the past years by producing novel devices and materials, which are currently applied in several fields of research and industry. Our interest is focused on biomedical applications of nanotechnologies to improve the therapeutics’ performances, as well as diagnostics. Successful nanodevices for drug or gene delivery, imaging or synthesized with materials acting per se (e.g., nanozimes) require full biocompatibility. Recent literature has highlighted the importance of host immune responses to nanomaterials as a critical issue to be addressed in order to create safe-by-design nanotools.

The present Special Issue would like to overcome the “classical nanotoxicology” as limited to toxicity results on cell death mechanisms, rather providing information on the several interactions that the immune system has with nanomaterials developed to biomedical applications. Novel results on immune cell, tissue or different animal models’ inflammatory responses to nanomaterials will be welcome, as well as critical review articles challenging the present knowledge and offering an expert platform to discussion.

Dr. Giuseppe Bardi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biomedical applications
  • immune-compatibility
  • innate immune system
  • adaptive immune system
  • immune responses
  • inflammation
  • immune cells
  • immune response
  • inflammatory mediators
  • cytokines
  • chemokines
  • phagocytosis

Published Papers (1 paper)

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Review

Open AccessReview Metallic Nanoparticles: General Research Approaches to Immunological Characterization
Nanomaterials 2018, 8(10), 753; https://doi.org/10.3390/nano8100753
Received: 4 September 2018 / Revised: 18 September 2018 / Accepted: 19 September 2018 / Published: 22 September 2018
PDF Full-text (857 KB) | HTML Full-text | XML Full-text
Abstract
Our immunity is guaranteed by a complex system that includes specialized cells and active molecules working in a spatially and temporally coordinated manner. Interaction of nanomaterials with the immune system and their potential immunotoxicity are key aspects for an exhaustive biological characterization. Several
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Our immunity is guaranteed by a complex system that includes specialized cells and active molecules working in a spatially and temporally coordinated manner. Interaction of nanomaterials with the immune system and their potential immunotoxicity are key aspects for an exhaustive biological characterization. Several assays can be used to unravel the immunological features of nanoparticles, each one giving information on specific pathways leading to immune activation or immune suppression. Size, shape, and surface chemistry determine the surrounding corona, mainly formed by soluble proteins, hence, the biological identity of nanoparticles released in cell culture conditions or in a living organism. Here, we review the main laboratory characterization steps and immunological approaches that can be used to understand and predict the responses of the immune system to frequently utilized metallic or metal-containing nanoparticles, in view of their potential uses in diagnostics and selected therapeutic treatments. Full article
(This article belongs to the Special Issue Immune Responses to Nanomaterials for Biomedical Applications)
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