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Special Issue "Polymer Biomaterials for Immune System Modulation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 15 July 2019

Special Issue Editors

Guest Editor
Dr. Giuseppe Bardi

Istituto Italiano di Tecnologia, Genoa, Italy
Website | E-Mail
Interests: nanobiointeractions; immune system; inflammation; nanoparticles
Guest Editor
Prof. Nicola Tirelli

Istituto Italiano di Tecnologia, Genoa, Italy
Website | E-Mail
Interests: polymer chemistry; colloid science; drug delivery; nanobiointeractions

Special Issue Information

Dear Colleagues,

Immune system (IS) activation may represent a major obstacle for drug delivery and pharmaceutical treatments in general; even when it is part of a beneficial outcome (e.g. vaccines), and the details of the response are critical to achieve a therapeutically valid target. Therefore, the possibility of modulating IS responses is a necessary component of precision medicine, allowing us to increase or decrease inflammatory processes in a fashion dependent on the therapeutic peculiarities.

For example, the efficacy of a given drug could be improved by using (nano)materials that hijack leukocytic machineries and upregulate specific processes, including cytokines or endo/phagocytic pathways. Biodegradable polymeric (nano)materials from synthetic or natural sources are advantageous in the tunability of their biological interactions through chemical/processing variables, which affect biocompatibility, (enzymatic) degradability, biodistribution and extracellular targeting, internalization and intracellular localization, the kinetics of drug release and transcription factor activation.

This Special Issue will welcome contributions ranging from materials design and processing (synthesis, functionalization, size control, microfluidics), through in vitro studies (new in vitro models, multicellular, 3D, microfluidics), to in vivo administration (pharmacokinetics, therapeutic outcomes), and will specifically focus on the immunological issues that accompany the use of (nano)materials and how the latter can influence them. This will include, but will not be limited to, studies aiming at dendritic cell targeting and vaccine development, topical and systemic anti-inflammatory therapies, cancer immunity applications, wound healing and angiogenetic processes.

Dr. Giuseppe Bardi
Prof. Nicola Tirelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Polymers
  • Nanoparticles
  • Microparticles
  • Matrices
  • Precision medicine
  • Regenerative medicine
  • Drug delivery
  • Immune system
  • Inflammation
  • Drug conjugates

Published Papers

This special issue is now open for submission.
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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