Special Issue "Immune Responses to Nanomaterials for Biomedical Applications 2.0"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 30 June 2023 | Viewed by 1823

Special Issue Editors

Dr. Giuseppe Bardi
E-Mail Website
Guest Editor
Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
Interests: innate immune system; chemokines; nanomaterials; nanobiointeractions; adjuvants
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Monica Neagu
E-Mail Website1 Website2
Guest Editor
1. Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania
2. Immunology Department, “Victor Babes” National Institute of Pathology, 050096 Bucharest, Romania
Interests: immuno-oncology; biomarkers; inflammation; melanoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to be guest editing the second Issue on the subject "Immune Responses to Nanomaterials for Biomedical Applications”. The number of novel nanodevices and nanomaterials with successful application is growing astonishingly. Their importance has been emphasized by the use of mRNA-new generation vaccine-nanocarriers for ceasing SARS-CoV-2 infection as a result of the COVID-19 pandemic.

Many nanomaterials are still on the research bench or are at pre-clinical stage. More information on their interaction with the immune system is needed in order to drive future applications safely. A huge part of these nanotools require deep investigation in order to define the adverse outcome pathway in immunotoxicity (AOP) of nanomaterials in order to create safe-by-design nanotools for diagnostic and therapeutic purposes.

Even synthetic or natural molecules, which are biocompatible as a single-molecule compound, could show a completely different behavior once organized in nanostructures. Early nanoparticle-induced immune responses, such as complement opsonization, phagocytosis, or hypersensitivity reactions using in vitro or in vivo models, are at the core of this comprehensive issue. Nevertheless, the direct or indirect involvement of nanoparticle mediated effects on adaptive responses, especially humoral responses to polymer nanoparticles or T cell mediated processing of protein viral-like particles, is of relevance to this topic.

The present Special Issue is intended to provide information on the several interactions that the immune system has with nanomaterials developed to biomedical applications. Novel results on immune cells, tissues, or diverse animal models in order to unravel their inflammatory responses to nanomaterials will be welcomed, as well as critical review articles challenging the present knowledge and offering an expert platform for discussion.

Dr. Giuseppe Bardi
Dr. Monica Neagu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Editorial
Moving Forward in Nano-Immune Interactions
Nanomaterials 2022, 12(12), 2033; https://doi.org/10.3390/nano12122033 - 13 Jun 2022
Viewed by 646
Abstract
This is the second Special Issue on the topic “Immune Responses to Nanomaterials for Biomedical Applications” [...] Full article
(This article belongs to the Special Issue Immune Responses to Nanomaterials for Biomedical Applications 2.0)
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Brief Report
Chemokine-Decorated Nanoparticles Target Specific Subpopulations of Primary Blood Mononuclear Leukocytes
Nanomaterials 2022, 12(20), 3560; https://doi.org/10.3390/nano12203560 - 11 Oct 2022
Viewed by 475
Abstract
Specific cell targeting to deliver nanoparticles can be achieved by tailored modifications of the material surface with chemical moieties. The selection of the cell targets can be optimized by covering the nanoparticle with molecules, the receptor expression of which is restricted to particular [...] Read more.
Specific cell targeting to deliver nanoparticles can be achieved by tailored modifications of the material surface with chemical moieties. The selection of the cell targets can be optimized by covering the nanoparticle with molecules, the receptor expression of which is restricted to particular cell subsets. Chemokines perform their biological action through 7-TM Gi-protein-coupled receptors differently expressed in all tissues. We decorated the surface of biocompatible polymer nanoparticles with full-length CCL5, an inflammatory chemokine that attracts leukocytes by binding CCR5, which is highly expressed in blood-circulating monocytes. Our observations showed that CCL5 functionalization does not affect the nanoparticle biocompatibility. Notably, CCL5 NPs delivered to PBMCs are selectively internalized by CCR5+ monocytes but not by CCR5- lymphocytes. The efficacy of PBMC subpopulation targeting by chemokine-decorated nanoparticles establishes an easy-to-use functionalization for specific leukocyte delivery. Full article
(This article belongs to the Special Issue Immune Responses to Nanomaterials for Biomedical Applications 2.0)
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