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Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

International Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, 197101 St. Petersburg, Russia
Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(1), 127;
Received: 15 November 2019 / Revised: 30 December 2019 / Accepted: 5 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue Immune Responses to Nanomaterials for Biomedical Applications)
For the widespread application of nanotechnology in biomedicine, it is necessary to obtain information about their safety. A critical problem is presented by the host immune responses to nanomaterials. It is assumed that the innate immune system plays a crucial role in the interaction of nanomaterials with the host organism. However, there are only fragmented data on the activation of innate immune system factors, such as toll-like receptors (TLRs), by some nanoparticles (NPs). In this study, we investigated TLRs’ activation by clinically relevant and promising NPs, such as Fe3O4, TiO2, ZnO, CuO, Ag2O, and AlOOH. Cytotoxicity and effects on innate immunity factors were studied in THP-1(Tohoku Hospital Pediatrics-1) cell culture. NPs caused an increase of TLR-4 and -6 expression, which was comparable with the LPS-induced level. This suggests that the studied NPs can stimulate the innate immune system response inside the host. The data obtained should be taken into account in future research and to create safe-by-design biomedical nanomaterials. View Full-Text
Keywords: nanoparticles; toll-like receptors; cytotoxicity nanoparticles; toll-like receptors; cytotoxicity
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MDPI and ACS Style

Vasilichin, V.A.; Tsymbal, S.A.; Fakhardo, A.F.; Anastasova, E.I.; Marchenko, A.S.; Shtil, A.A.; Vinogradov, V.V.; Koshel, E.I. Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes. Nanomaterials 2020, 10, 127.

AMA Style

Vasilichin VA, Tsymbal SA, Fakhardo AF, Anastasova EI, Marchenko AS, Shtil AA, Vinogradov VV, Koshel EI. Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes. Nanomaterials. 2020; 10(1):127.

Chicago/Turabian Style

Vasilichin, Vladislav A.; Tsymbal, Sergey A.; Fakhardo, Anna F.; Anastasova, Elizaveta I.; Marchenko, Andrey S.; Shtil, Alexander A.; Vinogradov, Vladimir V.; Koshel, Elena I. 2020. "Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes" Nanomaterials 10, no. 1: 127.

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