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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Components in Plants: Extraction, Characterization and Antioxidant Activity
edited by
submission deadline 15 Dec 2026 | 1 articles | Viewed by 1276 | Submission Open
Keywords: bioactive compounds; plant extracts; extraction of bioactives; polyphenols; chemical characterization; antioxidant activity; green chemistry
(This special issue belongs to the Section Natural Products Chemistry)
Bioactive Compounds and Biological Activity of Plants from the Cerrado and Amazon
edited by Paula Becker Pertuzatti, and Julia Teixeira De Paula
submission deadline 15 Dec 2026 | Viewed by 233 | Submission Open
Keywords: Cerrado plants; Amazon plants; natural products; sustainable biodiversity; health benefits; extraction and characterization
(This special issue belongs to the Section Natural Products Chemistry)
Featured Review Papers in Green Chemistry
edited by
submission deadline 15 Dec 2026 | Viewed by 195 | Submission Open
Keywords: green catalysts; green extraction and processing; chemistry based on natural products; bio-based solvents with sub- and super-critical fluids; microwave and ultrasound; organic reaction in green solvents; bioconversion of biomass and sustainable biomaterials; creating fine chemicals and polymers from renewable resources; green nanotechnology; green analytical chemistry; green degradation process
(This special issue belongs to the Section Green Chemistry)
Oxidative Stress and Cancer Therapy: Molecular Mechanisms, Drug Delivery, and Therapeutic Response
edited by
submission deadline 16 Dec 2026 | Viewed by 58 | Submission Open
Keywords: oxidative stress; reactive oxygen species; ROS; cancer therapy; anticancer agents; lipid peroxidation; ferroptosis; chemoresistance; drug resistance; antioxidant defense; redox signaling; redox homeostasis; drug delivery; nanomedicine; targeted delivery; combination therapy; immunogenic cell death; redox active compounds; natural products; therapeutic response
(This special issue belongs to the Section Chemical Biology)
Characterization of Organic Ligands: Correlations Between Results by Electrochemistry and Other Methods
edited by Eleonora-Mihaela Ungureanu
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1264 | Submission Open
Keywords: connections; electrochemical experiments; characterization of organic ligands; DFT calculations of ligand properties; optical methods; electrochemical methods; surface characterization methods (SEM; AFM; Raman; etc.); analytical methods
(This special issue belongs to the Section Applied Chemistry)
Terpenoids: Chemistry, Structural Diversity, and Biological Activities
edited by and Valentina Parisi
submission deadline 20 Dec 2026 | Viewed by 109 | Submission Open
Keywords: terpenoids; chemical diversity; specialised metabolites; drug discovery; plant-derived compounds; biological activity; biotechnology; metabolomics
(This special issue belongs to the Section Natural Products Chemistry)
Functional Supramolecular Gels: Design, Dynamics, and Applications submission deadline 20 Dec 2026 | Viewed by 96 | Submission Open
Keywords: hydrogels; organogels; ionogels; hybrid supramolecular gels; gel properties; gel applications
(This special issue belongs to the Section Materials Chemistry)
Rare Earth Materials: From Design to Applications
edited by Meng Ju
submission deadline 20 Dec 2026 | Viewed by 73 | Submission Open
Keywords: rare earth; crystal structure; spectral characteristic; luminescence; energy conversion; electronic properties; optical communications
(This special issue belongs to the Section Applied Chemistry)
AI in Materials Design and Discovery
edited by Guanjie Wang
submission deadline 20 Dec 2026 | Viewed by 61 | Submission Open
Keywords: materials informatics; materials large language model and agent; explainable machine learning; computational materials science; high-throughput screening; molecules inverse design; structure– property relationships; data-driven discovery
(This special issue belongs to the Section Materials Chemistry)
Phenolic Composition and Antioxidant Activity of Natural Products submission deadline 30 Dec 2026 | Viewed by 262 | Submission Open
Keywords: metabolomics; extracts; phenolic compounds; antioxidants; plants; fungi; lichens; phytotherapy
(This special issue belongs to the Section Natural Products Chemistry)
Bioactive Ingredients in Foods: Delivery, Stabilization, and Functionality submission deadline 30 Dec 2026 | Viewed by 200 | Submission Open
Keywords: antioxidant capacity; bioactive compounds; bioactive nutrients; carotenoids; food matrix; functional food; health benefits; natural sources; phytochemicals; polyphenols
(This special issue belongs to the Section Food Chemistry)
Recent Research Advances in Green Extraction of Natural Products submission deadline 30 Dec 2026 | Viewed by 178 | Submission Open
Keywords: sustainable chemistry; natural products; bio-based solvents; process intensification; sustainable extraction technologies; biomass valorization
(This special issue belongs to the Section Natural Products Chemistry)
Advancement in Natural and Novel Antimicrobial Agents submission deadline 30 Dec 2026 | Viewed by 132 | Submission Open
Keywords: bacterial priority list; antimicrobial resistance; natural compounds; novel antibacterial agents; synthetic antimicrobial compounds; extraction; synthesis; antimicrobial activity
(This special issue belongs to the Section Medicinal Chemistry)
Ab-Initio Molecular Dynamics Studies of Chemical Reactions in the Gas Phase, Condensed Phases and Interfaces
edited by Robert Benny Gerber and Imon Mandal
submission deadline 30 Dec 2026 | Viewed by 99 | Submission Open
Keywords: ab initio molecular dynamics; chemical reactions; reaction mechanism and dynamics; potential energy surfaces; trajectories
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Sustainable Electrochemical Platforms for Clinical and Environmental Determination submission deadline 30 Dec 2026 | Viewed by 59 | Submission Open
Keywords: sustainable electrochemistry; electrochemical biosensors; environmental monitoring; green synthesis; point-of-care diagnostics; biomass-derived carbon; emerging pollutants; nanocomposites; screen-printed electrodes; molecular detection
(This special issue belongs to the Section Electrochemistry)
Novel Polymer Materials for Environmental Applications submission deadline 30 Dec 2026 | Viewed by 56 | Submission Open
Keywords: bioplastics; polymer biocomposites; ecological packaging; polymer waste recovery; microplastics; photocatalytic polymers; conductive polymers; polymeric membranes; biodegradation of polymers
(This special issue belongs to the Section Materials Chemistry)
Advanced Techniques for the Chemical Analysis and Removal of Environmental Pollutants
edited by Anca-Iulia Stoica
submission deadline 30 Dec 2026 | Viewed by 52 | Submission Open
Keywords: pollutant monitoring; emerging contaminants; advanced techniques; removal of pollutants; eco-friendly treatments; nature-based solutions; environmental management
Drug Discovery Based on Non-Mammalian Models
edited by
submission deadline 30 Dec 2026 | Viewed by 11 | Submission Open
Keywords: disease models; drug discovery; zebrafish; drosophila melanogaster; caenorhabditis elegans
(This special issue belongs to the Section Medicinal Chemistry)
30th Anniversary of Molecules—Recent Advances in Organic Chemistry
edited by , Antonia Di Mola and
submission deadline 31 Dec 2026 | 19 articles | Viewed by 27942 | Submission Open
Keywords: organic synthesis; organic chemistry research; theoretical study; reaction mechanisms; catalysis
(This special issue belongs to the Section Organic Chemistry)
30th Anniversary of Molecules—Recent Advances in Chemical Biology submission deadline 31 Dec 2026 | 13 articles | Viewed by 24787 | Submission Open
Keywords: bioorthogonal chemistry; peptides; nucleic acids; proteins; analytical methods; chemical inhibitors; chemical probe; ubiquitination; structure-activity relationship
(This special issue belongs to the Section Chemical Biology)
30th Anniversary of Molecules: Recent Advances and the Next in Macromolecular Chemistry submission deadline 31 Dec 2026 | 9 articles | Viewed by 24375 | Submission Open
Keywords: macromolecular chemistry; synthetic polymers; natural polymers; polymerization mechanisms and kinetics; supramolecular self-assembly; biological macromolecules
(This special issue belongs to the Section Macromolecular Chemistry)
Advances in Coordination Chemistry, 3rd Edition
edited by Juan Niclós-Gutiérrez and
submission deadline 31 Dec 2026 | 8 articles | Viewed by 19035 | Submission Open
Keywords: synthesis strategies for novel coordination compounds; coordination compounds with tailor-made ligands for specific applications; coordination compounds with multitopic ligands; single-crystal XRD structures and dimensionality of metal complexes; metal– organic frameworks and their applications; molecular recognition in mixed ligand– metal complexes at the molecular and/or supra-molecular levels; model metal complexes from the bioinorganic frontier of biological chemistry; DFT and other theoretical approaches for inter-ligand interactions in metal complexes
(This special issue belongs to the Section Inorganic Chemistry)
Review Papers in Analytical Chemistry, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 16795 | Submission Open
Keywords: analytical chemistry; analytical spectroscopy; environmental sciences; medical science; forensic science; cultural heritage; food analysis
(This special issue belongs to the Section Analytical Chemistry)
30th Anniversary of Molecules—Recent Advances in Inorganic Chemistry submission deadline 31 Dec 2026 | 10 articles | Viewed by 14631 | Submission Open
Keywords: inorganic chemistry; coordination chemistry; solid-state chemistry; nanomaterials; organometallics; transition and main group metal chemistry; catalysis; bioinorganic chemistry
(This special issue belongs to the Section Inorganic Chemistry)
The 30th Anniversary of Molecules—Recent Advances in Natural Products Chemistry submission deadline 31 Dec 2026 | 6 articles | Viewed by 12121 | Submission Open
Keywords: natural compounds; bioactive molecules; drug discovery; pharmacological activity; formulations; drug delivery systems; food applications and additives; cosmetic applications; synthesis
(This special issue belongs to the Section Natural Products Chemistry)
30th Anniversary of Molecules—Recent Advances in Analytical Chemistry submission deadline 31 Dec 2026 | 4 articles | Viewed by 8775 | Submission Open
Keywords: chromatography and advanced mass spectrometry; atomic spectroscopy and elemental mass spectrometry; molecular spectroscopy; miniaturization of analytical instruments; ohmics; nanomaterials and sensors; automation and high-throughput screening; single-cell analysis; non-invasive analysis/techniques; green analytical chemistry
(This special issue belongs to the Section Analytical Chemistry)
Chemical Analysis of Pollutant in the Environment submission deadline 31 Dec 2026 | 5 articles | Viewed by 7850 | Submission Open
Keywords: inorganic and organic pollutants; persistent organic pollutants; heavy metals; nano- and microplastics; chemical methods; instrumental methods; validation
(This special issue belongs to the Section Green Chemistry)
Modern Trends and Solutions in Analytical Chemistry in Poland
edited by
submission deadline 31 Dec 2026 | 9 articles | Viewed by 7807 | Submission Open
Keywords: analytical and physical chemistry; separation sciences; chromatographic methods and related techniques (HPLC; SPE; SFC; GC; CZE; UPLC; GC × GC; and others); sample preparation and extraction techniques (SPE; QuEChERS/d-SPE; SPME; SBSE; HFLPME; DLLME; FUSLE; and others); detection techniques (DAD; FLD; MS; MS/MS; and others); spectrometry; bioanalytics; proteomics; metabolomics; and lipidomics; nanotechnology; environmental sciences; natural product chemistry (isolation; identification and quantification of bioactive compounds; and in vitro and then in vivo investigations on their biological activity); food analysis and food safety; xenobiotics analysis in environmental; biological; and food samples; chemometrics and statistical analysis
(This special issue belongs to the Section Analytical Chemistry)
Advance in Radiochemistry, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 6 articles | Viewed by 7473 | Submission Open
Keywords: radiochemistry; radionuclide (radioisotopes); radiolabeling; radiopharmaceutical (radiotracer); nuclear medicine; theranostics (diagnostics and therapeutics); molecular imaging
(This special issue belongs to the Section Medicinal Chemistry)
Advances and Opportunities of Natural Products in Drug Discovery submission deadline 31 Dec 2026 | 6 articles | Viewed by 7250 | Submission Open
Keywords: natural products; drug discovery; pharmacological activity; biological activity; new compounds
(This special issue belongs to the Section Natural Products Chemistry)
Recent Advances in Porous Materials, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 7155 | Submission Open
Keywords: porous carbon; adsorption; catalysis; supercapacitor; biomass; energy storage; zeolite; fuel cell; molecular sieves; metal– organic frameworks; porous metal oxide; mesoporous silicon; macroporous resin; aerogel; separation; porous composites; covalent organic frameworks
(This special issue belongs to the Section Materials Chemistry)
Back to Nature: Pharmacological Activities of Phytochemicals Isolated from Medicinal Plants
edited by and Ludmila Yarmolinsky
submission deadline 31 Dec 2026 | 7 articles | Viewed by 6643 | Submission Open
Keywords: medicinal plant; pharmacological activity; phytochemical; disease; drug; therapeutic; polyphenol; terpene; carotenoid; saponin; alkaloid; thiophene; sugar; fatty oil; resin; phytosterol; protein; peptide; anti-inflammatory; antidiabetic; neuroprotective; anticancer; antioxidative; antimicrobial; antiviral; antifungal
(This special issue belongs to the Section Natural Products Chemistry)
Chromatography—The Ultimate Analytical Tool, 3rd Edition submission deadline 31 Dec 2026 | 5 articles | Viewed by 6453 | Submission Open
Keywords: chromatography; high-performance liquid chromatography; ultra-high-performance liquid chromatography; gas chromatography; two-dimensional gas chromatography; two-dimensional liquid chromatography; paper chromatography; liquid chromatography; preparative chromatography; supercritical fluid chromatography; thin-layer chromatography
(This special issue belongs to the Section Analytical Chemistry)
30th Anniversary of Molecules—Recent Advances in Bioorganic Chemistry submission deadline 31 Dec 2026 | 7 articles | Viewed by 6452 | Submission Open
Keywords: bioorganic chemistry; chemoenzymatic synthesis; biocatalysis; biomimetic synthesis; biomolecular interactions; functional biomolecules; molecular recognition
(This special issue belongs to the Section Bioorganic Chemistry)
30th Anniversary of Molecules: Recent Advances in Photochemistry submission deadline 31 Dec 2026 | 5 articles | Viewed by 6211 | Submission Open
Keywords: organic photochemistry synthetic photochemistry; photocatalysis; photofunctionalization; photobiology; medicinal photochemistry; computational photochemistry; photoelectrochemistry; solar energy conversion; condensed and gas phase photochemistry; polymer photochemistry; supramolecular photochemistry; photochromism; luminescent sensors; photochemistry for environmental remediation
(This special issue belongs to the Section Photochemistry)
30th Anniversary of Molecules—Recent Developments in Biobased Polymers submission deadline 31 Dec 2026 | 4 articles | Viewed by 5997 | Submission Open
Keywords: biobased polymers; sustainability; biodegradability; polymer recycling; polymer composites; polymer processing; green chemistry
(This special issue belongs to the Section Materials Chemistry)
Recent Advances in Transition Metal Catalysis, 2nd Edition
edited by Dingyi Wang
submission deadline 31 Dec 2026 | 4 articles | Viewed by 5949 | Submission Open
Keywords: transition metal catalysis; photocatalysis; electrosynthesis; organic synthesis; asymmetric synthesis; C-H functionalization; C-C functionalization; C-X functionalization
(This special issue belongs to the Section Organic Chemistry)
Bee Product Chemistry: Identification and Characterization of Natural Compounds, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 5509 | Submission Open
Keywords: honey; wax; bee pollen; venom; propolis; royal jelly; bee larvae
(This special issue belongs to the Section Natural Products Chemistry)
30th Anniversary of the MOF Concept
edited by and
submission deadline 31 Dec 2026 | 4 articles | Viewed by 5485 | Submission Open
Keywords: metal– organic frameworks; gas storage and separation; catalysis; drug delivery; sensing and detection; energy applications
(This special issue belongs to the Section Organometallic Chemistry)
30th Anniversary of Molecules: Recent Advances in Organometallic Chemistry
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 5214 | Submission Open
Keywords: metal– organic framework; organometallic compounds; coordination assembly; metal– organic cluster; metal– organic cage; supramolecular chemistry
(This special issue belongs to the Section Organometallic Chemistry)
Novel Neuroprotective Agents: Design, Synthesis, and Biological Evaluation submission deadline 31 Dec 2026 | 1 articles | Viewed by 5121 | Submission Open
Keywords: neurodegenerative diseases; heterocyclic compounds; rational design; enzyme inhibitors; structure– activity relationship; structural characterization
(This special issue belongs to the Section Medicinal Chemistry)
30th Anniversary of Molecules—Recent Advances in Electrochemistry
edited by
submission deadline 31 Dec 2026 | 7 articles | Viewed by 4678 | Submission Open
Keywords: electrochemical science; energy conversion; charge transfer; voltammetry; magnetoelectrochemistry/spin; redox chemistry
(This special issue belongs to the Section Electrochemistry)
Quantum-Chemical Studies for Superspecies—in Celebration of Professor Jean-François Gal’s 80th Birthday
edited by
submission deadline 31 Dec 2026 | 6 articles | Viewed by 4000 | Submission Open
Keywords: structure of superspecies; neutral; ionic; and/or radical forms; isomerism; electron delocalization; energetic parameters of electron transfer; thermochemistry of proton transfer; quantum-chemical studies
Novel Nanomaterials for Photocatalysis submission deadline 31 Dec 2026 | 3 articles | Viewed by 3037 | Submission Open
Keywords: photocatalyst synthesis; band gap engineering; enhanced light absorption; clean energy; advanced oxidation/reduction processes; self-cleaning coatings; photocatalysis reaction mechanisms; artificial photosynthesis
(This special issue belongs to the Section Photochemistry)
Advances in Trace Element Analysis: Techniques and Applications
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 3013 | Submission Open
Keywords: trace element analysis; speciation techniques; environmental monitoring; atomic spectrometry; mass spectrometry; chromatography; bioavailability; environmental impact
(This special issue belongs to the Section Analytical Chemistry)
Optimization of Process Methodology for Specialty and Fine Chemicals
edited by and Łukasz Lamch
submission deadline 31 Dec 2026 | 5 articles | Viewed by 2928 | Submission Open
Keywords: process optimization; specialty and fine chemicals; process intensification; numerical and statistical optimization; design of experiments; green and sustainable chemistry; chemical engineering; data driven and model-based process design
(This special issue belongs to the Section Green Chemistry)
Heterocyclic Molecules in Drug Discovery submission deadline 31 Dec 2026 | 2 articles | Viewed by 2339 | Submission Open
Keywords: organic synthesis of bioactive heterocyclic compounds; structural analysis of heterocycles; biological activity of heterocycles; ADME properties of heterocycles; in silico analysis and experimental analysis of heterocyclic molecules
(This special issue belongs to the Section Medicinal Chemistry)
Plant Bioactive Compounds in Pharmaceuticals, 2nd Edition submission deadline 31 Dec 2026 | 2 articles | Viewed by 2268 | Submission Open
Keywords: bioactive compounds; medicinal plant; phytocomplexes; cell cultures
(This special issue belongs to the Section Natural Products Chemistry)
Photo- and Sonodynamic Antimicrobial and Anticancer Compounds submission deadline 31 Dec 2026 | 2 articles | Viewed by 2267 | Submission Open
Keywords: photosensitizers; sonosensitizers; photodynamic treatment; sonodynamic treatment; antimicrobials; anticancer treatment
(This special issue belongs to the Section Medicinal Chemistry)
Organometallic Compounds: Design, Synthesis and Application: 2nd Edition
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2021 | Submission Open
Keywords: organometallic compounds; design and synthesis; transition metal complexes; catalysis; metal coordination; catalytic applications; mechanisms; organic– inorganic hybrid compounds
(This special issue belongs to the Section Organometallic Chemistry)
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