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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant Metabolites: Isolation, Phytochemistry, and Biological Activities
edited by , Karolina Grabowska and
submission deadline 31 Oct 2025 | Viewed by 92 | Submission Open
Keywords: isolation; plant metabolites; plant extracts; medicinal plants; biological activity assessment
(This special issue belongs to the Section Natural Products Chemistry)
Graphene and Graphene-Related Materials for Energy and Environment: Synthesis and Application submission deadline 31 Oct 2025 | Viewed by 92 | Submission Open
Keywords: graphene; graphene-related materials; energy applications; fuel cells; capacitors; photocatalysis; adsorption
(This special issue belongs to the Section Materials Chemistry)
Novel Flame Retardant Materials
edited by
submission deadline 31 Oct 2025 | Viewed by 90 | Submission Open
Keywords: novel flame retardants; flame-retardant polymers; bio-based flame retardants; flame-retardant coatings; environmentally friendly flame-retardant textiles; flame-retardant nanocomposites; flame retardant mechanism research
(This special issue belongs to the Section Materials Chemistry)
Design, Synthesis and Biological Activity of Novel Antitumor Drugs, 2nd Edition submission deadline 31 Oct 2025 | Viewed by 86 | Submission Open
Keywords: novel target; anticancer; small molecules; biological evaluation; synthesis; activity assay; molecular modeling
(This special issue belongs to the Section Medicinal Chemistry)
Feature Papers in Applied Chemistry: 4th Edition
edited by
submission deadline 31 Oct 2025 | Viewed by 82 | Submission Open
Keywords: applied chemistry; new molecules/materials; analytical methods and techniques; electrochemistry and catalysis; new materials and medicines
(This special issue belongs to the Section Applied Chemistry)
New Insights into Protein and Biomolecule Interactions
edited by Xin Peng and
submission deadline 31 Oct 2025 | Viewed by 79 | Submission Open
Keywords: protein; biomolecule; interaction; protein-biomolecule interactions; structural insights; drug development
(This special issue belongs to the Section Bioorganic Chemistry)
Signaling Pathways as Targets in Disease Therapy
edited by and
submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open
Keywords: small molecule inhibitors; signaling pathway; homeostasis maintenance; targeted therapy; cancer cells; metabolic diseases
(This special issue belongs to the Section Medicinal Chemistry)
Discovery, Isolation, and Mechanisms of Bioactive Natural Products (2nd Edition)
edited by
submission deadline 31 Oct 2025 | Viewed by 60 | Submission Open
Keywords: natural products; bioactivities; structural elucidation; mechanisms
(This special issue belongs to the Section Natural Products Chemistry)
Neurochemistry: Recent Advances and Future Opportunities in Antidepressants and Mood Stabilizers
edited by
submission deadline 31 Oct 2025 | Viewed by 58 | Submission Open
Keywords: neurochemistry; antidepressants; mood stabilizers; neurotransmitters; neuroplasticity; biomarkers; inflammation and mood disorders; personalized medicine; rapid-acting therapeutics; mechanisms of action
(This special issue belongs to the Section Medicinal Chemistry)
Design and Synthesis of Novel Adsorbents for Pollutant Removal, 2nd Edition
edited by
submission deadline 31 Oct 2025 | Viewed by 58 | Submission Open
Keywords: wastewater treatment; adsorbents; sustainable materials; adsorption mechanisms; surface chemistry; selective adsorption
(This special issue belongs to the Section Physical Chemistry)
Advances in Metal/Oxide Interfacial Catalysts: Design, Properties, and Applications
edited by Mausumi Mahapatra
submission deadline 31 Oct 2025 | Viewed by 54 | Submission Open
Keywords: oxides; metal– oxide interface; catalysts; active sites; heterogeneous catalysis
(This special issue belongs to the Section Physical Chemistry)
Bioactive Compounds for Brain Ischemia and Neurodegenerative Disease—3rd Edition submission deadline 31 Oct 2025 | Viewed by 54 | Submission Open
Keywords: brain; neuroprotection; neurodegenerative diseases; ischemia; mitochondria; oxidative stress; inflammation; bioactive compounds
(This special issue belongs to the Section Medicinal Chemistry)
Extraction Techniques for Sample Preparation submission deadline 31 Oct 2025 | Viewed by 50 | Submission Open
Keywords: sorbent-based extraction; liquid-based extraction; supercritical- or subcritical-based extraction; HPLC determination; GC determination; LC-MS-based analysis; chemical fingerprinting
(This special issue belongs to the Section Analytical Chemistry)
Advanced Materials for Energy Conversion and Water Sustainability, 2nd Edition
edited by and
submission deadline 31 Oct 2025 | Viewed by 49 | Submission Open
Keywords: advanced material innovation; energy conversion; desalination; wastewater treatment; pollutant degradation; sustainable clean water harvesting
(This special issue belongs to the Section Applied Chemistry)
Vibrational Spectroscopy and Imaging of Mineralized Tissues and Biomaterials
edited by William Querido
submission deadline 31 Oct 2025 | Viewed by 49 | Submission Open
Keywords: vibrational spectroscopy; infrared and Raman spectroscopy; hyperspectral imaging; biomineralization; mineralized tissues and biomaterials; skeletal and dental tissue engineering; machine learning in spectral analysis
(This special issue belongs to the Section Analytical Chemistry)
Process Intensification Technology in Chemical Reaction
edited by
submission deadline 31 Oct 2025 | Viewed by 48 | Submission Open
Keywords: chemical process intensification; heat and mass transfer; intensification mechanism; reaction rate; resource and energy efficiency; miniaturization; sustainability
(This special issue belongs to the Section Green Chemistry)
Advancements in Silicon-Based Materials: Synthesis, Properties and Applications submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open
Keywords: silica synthesis: acidic and/or basic; sol-gel technique; synthesis of polymer/mesoporous silica nanocomposites; silica; characterization of silicate; citrus waste on silica; supports for catalysts; antimicrobial silica; circular economy
(This special issue belongs to the Section Materials Chemistry)
Nano and Micro Materials in Green Chemistry
edited by Ruijin Yu
submission deadline 31 Oct 2025 | Viewed by 46 | Submission Open
Keywords: green chemistry; biosynthesis and green synthesis; nanomaterials and micro-materials; biohybrid materials; nanostructured electrodes; chemical sustainability assessment
(This special issue belongs to the Section Materials Chemistry)
Next-Generation Catalytic Materials for Environmental Sustainability and Energy Efficiency
edited by
submission deadline 31 Oct 2025 | Viewed by 46 | Submission Open
Keywords: environmental catalysis; renewable energy; catalytic materials; photo(electro)catalysis; environmental Remediation; energy eaterials
(This special issue belongs to the Section Green Chemistry)
Design, Synthesis and Applications of Fluorescent Probes
edited by and
submission deadline 31 Oct 2025 | Viewed by 45 | Submission Open
Keywords: fluorescent probes; bioimaging; design synthesis; molecular imaging; cell biology; disease mechanisms; diagnostic imaging; drug discovery; biocompatibility
(This special issue belongs to the Section Medicinal Chemistry)
Electrochemical Catalytic Conversion of Small Molecules submission deadline 31 Oct 2025 | Viewed by 44 | Submission Open
Keywords: electrocatalysis; small molecule conversion; single-atom catalysis; mechanism study; sustainable energy
(This special issue belongs to the Section Electrochemistry)
Advanced Vibrational Spectroscopy
edited by Ke Lin
submission deadline 31 Oct 2025 | Viewed by 44 | Submission Open
Keywords: vibrational spectroscopy; molecular structure; molecular interaction; probe; excess spectroscopy; difference spectroscopy; ratio spectroscopy; multivariate curve resolution; two-dimensional correlation spectroscopy; Raman spectroscopy; infrared spectroscopy
(This special issue belongs to the Section Analytical Chemistry)
Advanced Electrode Materials for Aqueous Batteries
edited by
submission deadline 31 Oct 2025 | Viewed by 41 | Submission Open
Keywords: aqueous batteries; electrode materials; energy storage; electrochemical stability; ion intercalation; nanostructured materials
(This special issue belongs to the Section Materials Chemistry)
Plasmonic Metal Nanoparticles: From Synthesis to Major Applications
edited by
submission deadline 31 Oct 2025 | Viewed by 40 | Submission Open
Keywords: metal nanoparticles and nanoclusters; plasmonic metal nanoparticles; metal nanocomposites; shape-selected synthesis; size-selected synthesis; functional properties; high-resolution electron microscopy; surface plasmon resonance; interfacial properties; surface modification; catalysis; plasmonics; surface-enhanced Raman scattering; biomedical sensing; environmental sensing
(This special issue belongs to the Section Physical Chemistry)
Design, Preparation, and Application of Flexible Electrodes in Energy Storage
edited by and
submission deadline 31 Oct 2025 | Viewed by 36 | Submission Open
Keywords: flexible electrodes; energy storage; 2D nanomaterials; conductive polymers; photovoltaics cells; supercapacitors; lithium-ion batteries; scalable manufacturing
(This special issue belongs to the Section Materials Chemistry)
Advanced Bioactive Nanoparticles for Precision Medicine
edited by and Erica Quagliarini
submission deadline 31 Oct 2025 | Viewed by 33 | Submission Open
Keywords: bioactive nanoparticles; targeted drug delivery; molecular imaging; stimuli-responsive nanocarriers; surface functionalization; hybrid nanomaterials; precision nanomedicine; clinical translation
(This special issue belongs to the Section Medicinal Chemistry)
Halogen Bonding and Chalcogen Bonding in Polymer and Supramolecular Materials
edited by Andrew Docker
submission deadline 1 Nov 2025 | Viewed by 244 | Submission Open
Keywords: halogen bonding; chalcogen bonding; supramolecular materials; polymer materials
(This special issue belongs to the Section Materials Chemistry)
Advances in Small Molecule Inhibitor-Based Drug Discovery Through Computational Chemistry submission deadline 3 Nov 2025 | Viewed by 22 | Submission Open
Keywords: drug discovery; medicinal chemistry; molecular modeling; natural inhibitors; antiviral; small inhibitors
(This special issue belongs to the Section Bioorganic Chemistry)
Insights on the Electron Transport in Electrolytes
edited by Chao Fang and Jiale Ma
submission deadline 10 Nov 2025 | Viewed by 44 | Submission Open
Keywords: electron transport; electrolytes; energy storage technologies; material properties; electrochemistry
Advances in Lignin-Based Biomaterials: Synthesis and Characterizations submission deadline 15 Nov 2025 | Viewed by 157 | Submission Open
Keywords: lignin; lignin-based biomaterials; chemical characterization; functionalization; depolymerization; reprocessability
(This special issue belongs to the Section Green Chemistry)
Studies in Polymer Degradation
edited by , Edcleide Maria Araujo and Bastos Y. M. De Almeida
submission deadline 15 Nov 2025 | Viewed by 69 | Submission Open
Keywords: degradation mechanisms; photooxidation; thermal degradation; upcycling technologies and additivities
(This special issue belongs to the Section Macromolecular Chemistry)
Recent Insights into Biopolymer Processing, from Preparation to Fundamental Properties and Industrial Applications, 2nd Edition submission deadline 15 Nov 2025 | Viewed by 41 | Submission Open
Keywords: biopolymers; biomaterials; renewables; properties; applications; sustainability; circular economy
Functional Adsorption Materials for Catalytic Degradation in Pollution Chemistry submission deadline 15 Nov 2025 | Viewed by 38 | Submission Open
Keywords: adsorptive catalysis; pollutant degradation; functional meterials; environmental remediation; hybride adsorbents; water and air purification
(This special issue belongs to the Section Applied Chemistry)
Advances in Dyes and Photochromics submission deadline 16 Nov 2025 | 1 articles | Viewed by 672 | Submission Open
Keywords: photochromic compounds; green chemistry; molecular engineering; smart materials; environmental monitoring; electronic textiles; light-responsive materials; functional dyes; optical data storage; biomedical applications
(This special issue belongs to the Section Photochemistry)
Applied Analytical Chemistry: Second Edition
edited by
submission deadline 30 Nov 2025 | 8 articles | Viewed by 14991 | Submission Open
Keywords: food production; forensic practice and archaeology; environmental monitoring; clinical practice; quality control in industry; analysis of plant material
(This special issue belongs to the Section Analytical Chemistry)
Advances in Polymer Materials Based on Lignocellulosic Biomass
edited by Roland El Hage and
submission deadline 30 Nov 2025 | 13 articles | Viewed by 12089 | Submission Open
Keywords: natural fibers; agricultural wastes; pre-treatments; functionalisation; sustainability
(This special issue belongs to the Section Materials Chemistry)
10th Anniversary of Green Chemistry Section submission deadline 30 Nov 2025 | 13 articles | Viewed by 11021 | Submission Open
Keywords: green catalysts; green extraction and processing; chemistry based on natural products; bio-based solvents with sub- and super-critical fluids; microwave and ultrasound; organic reaction in green solvents; bioconversion of biomass and sustainable biomaterials; creating fine chemicals and polymers from renewable resources; green nanotechnology; green analytical chemistry; green degradation process
(This special issue belongs to the Section Green Chemistry)
Pharmaceutical Modelling in Physical Chemistry submission deadline 30 Nov 2025 | 5 articles | Viewed by 8562 | Submission Open
Keywords: pharmaceutical modelling; virtual screening; machine learning; molecular dynamics; enhanced sampling; ab initio calculations
(This special issue belongs to the Section Physical Chemistry)
Insights for Organofluorine Chemistry, 2nd Edition
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 6118 | Submission Open
Keywords: organofluorine compounds; fluorination; fluoroalkylation; fluorination reagents; fluoroalkylation reagents; fluorine building blocks; fluorine drugs; fluorine pesticides; fluorinated materials
(This special issue belongs to the Section Organic Chemistry)
Functional Evaluation of Bioactive Compounds from Natural Sources, 2nd Edition submission deadline 30 Nov 2025 | 5 articles | Viewed by 6113 | Submission Open
Keywords: bioactive compounds; natural sources; functional evaluation; biological activities; health benefits; mechanisms of action; bioactivity; phytochemicals
(This special issue belongs to the Section Natural Products Chemistry)
Advanced Luminescent Materials: From Design, Synthesis, Fluorescent Mechanism to Applications
edited by Wei Chen
submission deadline 30 Nov 2025 | 4 articles | Viewed by 5546 | Submission Open
Keywords: fluorescent probes; bioimaging; biosensing; biomaterials
(This special issue belongs to the Section Nanochemistry)
Heterophase Polymerization and Functional Polymer Microspheres/Microcapsules
edited by Chengyou Kan and Wei Deng
submission deadline 30 Nov 2025 | 5 articles | Viewed by 5263 | Submission Open
Keywords: emulsion polymerization; mini emulsion polymerization; dispersion polymerization; suspension polymerization; encapsulation; functionalization; polymer microspheres; microcapsules; characterization; morphology control; structure– property relationship; polymer nanocomposite; application
(This special issue belongs to the Section Materials Chemistry)
10th Anniversary of the Bioorganic Chemistry Section of Molecules submission deadline 30 Nov 2025 | 6 articles | Viewed by 5024 | Submission Open
Keywords: chemoenzymatic synthesis and use of enzymes in organic chemistry; enzyme inhibitors; enzyme immobilization and controlled enzyme immobilization; biocatalysis (ribozymes and catalytic antibodies); biosynthesis; combinatorial biosynthesis; biomimetic synthesis; synthetic glycobiology; immunochemical techniques; membrane chemistry; protein and small biomolecules; protein– protein interactions; protein– molecule interactions; functional proteins and peptides; peptide chemistry; biopolymers and artificial supramolecular assemblies; the organic chemistry aspects of genetic engineering; neurotoxins and neuronal receptors; molecular recognition of nucleic acids; bioactive lipids; non-natural amino acids; mass spectrometry studies on biomolecules; bioactive peptides and proteins; biological signalling
(This special issue belongs to the Section Bioorganic Chemistry)
Featured Reviews in Organometallic Chemistry, 2nd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4984 | Submission Open
Keywords: organometallic chemistry; complexes; metals; metal– carbon bonding; main group metals; transition metals; lanthanides; catalysis; ligands; metal chemistry; phosphines; N-heterocyclic carbenes; bipyridines; homogeneous catalysis; cross coupling; bond activation; ancillary ligands; photoredox catalysis; asymmetric catalysis; crystallography; spectroscopy
(This special issue belongs to the Section Organometallic Chemistry)
Synthesis and Crystal Structure of Rare-Earth Metal Compounds
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4657 | Submission Open
Keywords: synthesis; crystal structure; luminescence; magnetism; catalysts; optical properties
(This special issue belongs to the Section Inorganic Chemistry)
Advances in Green Solvents for Analytical Chemistry: Deep Eutectic Solvents and Biosolvents submission deadline 30 Nov 2025 | 2 articles | Viewed by 3432 | Submission Open
Keywords: eutectic Solvents; biosolvents; green chemistry; microextraction techniques; environmentally friendly methods; green sample preparation; chromatography modifiers; sample preparation
(This special issue belongs to the Section Analytical Chemistry)
Recent Advances in the Valorization of Food, Agricultural By-Products and Waste, 2nd Edition submission deadline 30 Nov 2025 | 6 articles | Viewed by 3393 | Submission Open
Keywords: agro-food byproducts; green extraction methods; bioactive compounds; in vitro analysis; ex vivo and in vivo studies; health benefits; nutraceuticals
(This special issue belongs to the Section Green Chemistry)
Research Progress of New Antimicrobial Drugs submission deadline 30 Nov 2025 | 6 articles | Viewed by 3174 | Submission Open
Keywords: synthesis of new antimicrobials; bioactive compounds; antimicrobial derivatives; synthetic and natural compounds; pathogens and opportunistic microbes; prevention and treatment; antibiofilm; discovery of antimicrobials
(This special issue belongs to the Section Medicinal Chemistry)
Recent Advances in Supramolecular Chemistry
edited by Wen-Chao Geng
submission deadline 30 Nov 2025 | 4 articles | Viewed by 3166 | Submission Open
Keywords: supramolecular chemistry; molecular recognition; self-assembly; supramolecular materials; macrocycles
(This special issue belongs to the Section Macromolecular Chemistry)
Recent Advances in Mass Spectrometry Analysis for Medical and Pharmaceutical Applications
edited by Wojciech Piekoszewski
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3154 | Submission Open
Keywords: mass spectrometry (MS); biomarkers; drug metabolism; proteomics; metabolomics; pharmaceutical analysis; personalized medicine; therapeutic drug monitoring
(This special issue belongs to the Section Analytical Chemistry)
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