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Advances in Remediation Methods of Pharmaceutical Pollutants in Water

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 972

Special Issue Editors


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Guest Editor
Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
Interests: environmental pollutants; pharmaceutical analysis; drug metabolism; mass spectrometry; photodegradation; electrochemical oxidation

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Guest Editor
Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
Interests: photodegradation; electrochemical oxidation; AOPs; PPCPs pollution; ecotoxicology; xenobiotic metabolism; mass spectrometry
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Special Issue Information

Dear Colleagues,

Pharmaceuticals currently represent one of the main groups of organic pollutants in surface waters and particularly in rivers. This situation is influenced by the growing consumption of medicines by humans, their increasingly widespread use in veterinary medicine as well as agriculture, and their improper disposal.

At the same time, the conventional wastewater treatment methods currently in use are not very effective, and most pharmaceuticals, either in their unchanged form or as secondary metabolites and degradation products, enter the natural environment, where they can impact non-target organisms.

For this reason, there is an urgent need to develop high-efficiency, safe, and cost-effective modern methods for removing pharmaceuticals from water.

Therefore, this Special Issue focuses on the application of advanced methods for the purification of water and wastewater from pharmaceuticals, particularly, but not exclusively, using photochemical and electrochemical techniques. Papers discussing structural identification of the formed transformation products, as well as their toxic properties, are also welcome.

Prof. Dr. Robert Skibiński
Dr. Jakub Trawiński
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug pollutants
  • advanced oxidation processes
  • water treatment
  • electrochemical methods
  • photodegradation
  • degradation pathways
  • mineralization
  • toxicity assessment

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Published Papers (1 paper)

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Research

22 pages, 2984 KB  
Article
Electrochemical Removal of Cephalosporin Antibiotic—Cefuroxime Axetil from Aquatic Media Using Boron-Doped Diamond Electrodes: Process Optimization, Degradation Studies and Transformation Products Characterization
by Michał Wroński, Jakub Trawiński and Robert Skibiński
Molecules 2026, 31(1), 106; https://doi.org/10.3390/molecules31010106 - 26 Dec 2025
Cited by 1 | Viewed by 719
Abstract
Growing environmental concern over pharmaceutical contaminants in water, combined with the limited effectiveness of conventional treatment methods in removing persistent antibiotics, creates a need for advanced remediation technologies. This study investigates the degradation of the cephalosporin antibiotic cefuroxime axetil using an electrochemical advanced [...] Read more.
Growing environmental concern over pharmaceutical contaminants in water, combined with the limited effectiveness of conventional treatment methods in removing persistent antibiotics, creates a need for advanced remediation technologies. This study investigates the degradation of the cephalosporin antibiotic cefuroxime axetil using an electrochemical advanced oxidation process with a boron-doped diamond (BDD) anode. Experiments were conducted under varying pH levels and in natural water matrices, specifically river and lake water, to evaluate the process efficiency under realistic conditions. Significant differences were observed between matrices, with the best result obtained in river water, enabling complete degradation of cefuroxime axetil within 30 min. To clarify the factors influencing process efficiency, additional experiments examined the effects of dissolved organic matter (DOM) and chlorides. Cefuroxime axetil proved highly susceptible to electrooxidation, generally following pseudo-first-order kinetics, and chloride significantly accelerated its degradation. Using high-resolution mass spectrometry, ten transformation products were identified, including six not previously reported in the literature, representing a key novelty of this work. Their potential aquatic toxicity was subsequently evaluated in silico using fish and algae models. Finally, energy consumption analysis was conducted to evaluate the impact of various factors on the process’s economic efficiency. Full article
(This article belongs to the Special Issue Advances in Remediation Methods of Pharmaceutical Pollutants in Water)
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