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Special Issue "Multicomponent Reaction-Based Synthesis of Bioactive Molecules"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 June 2017).

Special Issue Editors

Prof. Dr. Diego Muñoz-Torrero
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Guest Editor
Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain
Interests: multitarget anti-Alzheimer agents; hybrid compounds; cholinesterase inhibitors; amyloid anti-aggregating compounds; BACE-1 inhibitors; antiprotozoan compounds
Special Issues and Collections in MDPI journals
Prof. Dr. Rodolfo Lavilla
Guest Editor
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain
Interests: multicomponent reactions; heterocyclic chemistry; scaffolds for medicinal chemistry; functional fluorophores; chemical biology
Prof. Dr. Christopher Hulme
Guest Editor
Department of Pharmacology and Toxicology, and Department of Chemistry and Biochemistry, College of Pharmacy, The University of Arizona, Biological Sciences West Room 351, 1041 East Lowell Street, Tucson, Arizona 85721, USA
Interests: multicomponent reactions; medicinal chemistry; diversity oriented synthesis; neurodegeneration

Special Issue Information

Dear Colleagues,

Multicomponent reactions (MCRs) involve the one-pot combination of three or more reactants to afford single products that feature structural elements of all the starting materials, thereby displaying a high degree of synthetic efficiency and atom economy. Because of their modular features, MCRs generate complex products, ideally in one step, amenable to a broad range of substitution patterns. This strategy represents a powerful tool for combinatorial and diversity-oriented synthesis, and hence, a compelling approach for new hit discovery and hit-to-lead optimization campaigns. As a consequence, MCRs are having a tremendous impact in drug discovery both in the pharmaceutical industry and in academia.

In this Special Issue, we intend to collect original research articles and short communications about medicinal chemistry projects where MCRs have played an important role in the synthesis of the target biologically active compounds or their advanced precursors. Review articles that address the role of known MCRs and the design of novel MCRs for drug discovery will be also welcome.

Prof. Dr. Diego Muñoz-Torrero
Prof. Dr. Rodolfo Lavilla
Prof. Dr. Christopher Hulme
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • multicomponent reactions
  • drug discovery
  • hit-to-lead optimization
  • diversity-oriented synthesis
  • structural complexity
  • exploratory power
  • iterative efficiency

Published Papers (7 papers)

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Open AccessCommunication
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases
Molecules 2018, 23(1), 177; - 16 Jan 2018
Cited by 3
Open AccessArticle
Multienzyme Biosynthesis of Dihydroartemisinic Acid
Molecules 2017, 22(9), 1422; - 28 Aug 2017
Cited by 10
Open AccessArticle
A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
Molecules 2017, 22(8), 1296; - 09 Aug 2017
Open AccessArticle
An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities
Molecules 2017, 22(8), 1278; - 03 Aug 2017
Cited by 4
Open AccessArticle
Synthesis and Biological Evaluation of New Substituted Hantzsch Thiazole Derivatives from Environmentally Benign One-Pot Synthesis Using Silica Supported Tungstosilisic Acid as Reusable Catalyst
Molecules 2017, 22(5), 757; - 07 May 2017
Cited by 11
Open AccessArticle
An Efficient One-Pot Protocol for the Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones Using Metallophthalocyanines (MPcs) as Potent Heterogeneous Catalysts: Synthesis, Characterization, Aggregation and Antimicrobial Activity
Molecules 2017, 22(4), 605; - 09 Apr 2017
Cited by 7
Open AccessCommunication
Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities of the Products
Molecules 2017, 22(2), 254; - 08 Feb 2017
Cited by 4
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