Molecules against Alzheimer II

Dear Colleagues,

The prevalence, mortality and economic figures associated with Alzheimer’s disease (AD) are continuously beating the most worrisome predictions. The ever-increasing impact of AD is leading to unbearable suffering for patients, relatives and caregivers, and will put health systems and national economies worldwide at unmanageable risk if drug development efforts are not successful. The social awareness of the huge burden of AD and the tremendous decades-long research efforts to delineate their pathogenic mechanisms and develop efficient therapies have not corresponded with the discovery of new drugs that have proven capable of halting or even just slowing down the neurodegenerative processes occurring in AD. Indeed, AD is one of the therapeutic areas with the highest attrition rates in clinical trials. However, this should not discourage us from maintaining our intensive research endeavors, rather the opposite. In this light, the best-established (but so far unproductive) working hypotheses on the pathogenic mechanisms of AD are being continuously revisited and new promising hypotheses are being drawn up, thereby providing very valuable clues for the development of the long-sought-after disease-modifying drugs.

Following the successful first edition, this Special Issue aims to gather recent medicinal chemistry works focused on the discovery of novel biological targets, diagnostic tools and drug candidates and the application of innovative CNS drug delivery systems and therapeutic approaches that can improve the early detection and treatment of AD. We welcome original articles and short communications as well as a limited number of review articles on these topics. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on the Special Issue website.

Prof. Dr. Diego Muñoz-Torrero
Prof. Dr. Michael Decker
Guest Editors

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