A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line

Chen, Hongbin; Xu, Yang; Zhang, Yinan; Zheng, Zongping

doi:10.3390/molecules22081296

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A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line

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Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Alge, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China

School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China

College of pharmacy, University of Kentucky, Lexington, KY 40536, USA

Author to whom correspondence should be addressed.

Molecules 2017, 22(8), 1296; https://doi.org/10.3390/molecules22081296

Received: 29 June 2017 / Accepted: 2 August 2017 / Published: 9 August 2017

(This article belongs to the Special Issue Multicomponent Reaction-Based Synthesis of Bioactive Molecules)

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Abstract

In this study, a convenient approach and green procedure for the synthesis of 4-phenacylideneflavenes has been developed from the reaction between 2,4-dihydroxybenzaldehyde and substituted acetophenones using boric acid as a catalyst in polyethylene glycol 400. Seven 4-phenacylideneflavenes were synthetized and their structures were confirmed by NMR and mass spectral analyses. Meanwhile, their possible mechanism of formation was also discussed. These products were found to have potential cytotoxic effect on HepG2 cell line with IC₅₀ values from 12.5 to 50 µM. View Full-Text

Keywords: substituted acetophenones; 2,4-dihydroxybenzaldehyde; 4-phenacylideneflavenes; cytotoxic effect; HepG2 cell line

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Chen, H.; Xu, Y.; Zhang, Y.; Zheng, Z. A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line. Molecules 2017, 22, 1296. https://doi.org/10.3390/molecules22081296

AMA Style

Chen H, Xu Y, Zhang Y, Zheng Z. A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line. Molecules. 2017; 22(8):1296. https://doi.org/10.3390/molecules22081296

Chicago/Turabian Style

Chen, Hongbin, Yang Xu, Yinan Zhang, and Zongping Zheng. 2017. "A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line" Molecules 22, no. 8: 1296. https://doi.org/10.3390/molecules22081296

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A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line

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