A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
1
Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Alge, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China
2
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China
3
College of pharmacy, University of Kentucky, Lexington, KY 40536, USA
*
Author to whom correspondence should be addressed.
Molecules 2017, 22(8), 1296; https://doi.org/10.3390/molecules22081296
Received: 29 June 2017 / Accepted: 2 August 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Multicomponent Reaction-Based Synthesis of Bioactive Molecules)
In this study, a convenient approach and green procedure for the synthesis of 4-phenacylideneflavenes has been developed from the reaction between 2,4-dihydroxybenzaldehyde and substituted acetophenones using boric acid as a catalyst in polyethylene glycol 400. Seven 4-phenacylideneflavenes were synthetized and their structures were confirmed by NMR and mass spectral analyses. Meanwhile, their possible mechanism of formation was also discussed. These products were found to have potential cytotoxic effect on HepG2 cell line with IC50 values from 12.5 to 50 µM.
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Keywords:
substituted acetophenones; 2,4-dihydroxybenzaldehyde; 4-phenacylideneflavenes; cytotoxic effect; HepG2 cell line
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MDPI and ACS Style
Chen, H.; Xu, Y.; Zhang, Y.; Zheng, Z. A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line. Molecules 2017, 22, 1296.
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