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Development of Spectrochemical Imaging with Infrared and Raman Techniques

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (1 June 2023) | Viewed by 2069

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Guest Editor
Institute of Physical and Theoretical Chemistry, Universitat Tubingen, Tubingen, Germany
Interests: spectrochemical imaging; biophysics; protein dynamics; hyperspectral imaging; confocal Raman imaging; chemometrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infrared and Raman imaging are exciting analytical techniques that allow us to answer the question of what chemical species are present in a sample, and furthermore, these techniques can also tell us how much of a species is present and, even more importantly, where it is located.

Combining spectroscopic techniques with microscopic and macroscopic imaging capabilities opens up the possibility of answering these questions with a single measurement.

This results in the possibility of chemical imaging with which spatial and spectral information of samples can be obtained with high speed and spatial and spectral resolution.

Thus, this method allows us to perform detailed analysis of complex heterogeneous samples.

Due to the rapid development of the speed of data analysis and the improvement of the technical components of imaging equipment, this technology is constantly opening up new possibilities, to which we would like to devote special attention in this Special Issue.

Prof. Dr. Marc Brecht
Guest Editor

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Keywords

  • NIR imaging
  • Raman imaging
  • Chemical imaging

Published Papers (1 paper)

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Research

13 pages, 2480 KiB  
Article
Gradient SERS Substrates with Multiple Resonances for Analyte Screening: Fabrication and SERS Applications
by Ashutosh Mukherjee, Quan Liu, Frank Wackenhut, Fang Dai, Monika Fleischer, Pierre-Michel Adam, Alfred J. Meixner and Marc Brecht
Molecules 2022, 27(16), 5097; https://doi.org/10.3390/molecules27165097 - 10 Aug 2022
Cited by 3 | Viewed by 1592
Abstract
Surface-enhanced Raman spectroscopy (SERS) provides a strong enhancement to an inherently weak Raman signal, which strongly depends on the material, design, and fabrication of the substrate. Here, we present a facile method of fabricating a non-uniform SERS substrate based on an annealed thin [...] Read more.
Surface-enhanced Raman spectroscopy (SERS) provides a strong enhancement to an inherently weak Raman signal, which strongly depends on the material, design, and fabrication of the substrate. Here, we present a facile method of fabricating a non-uniform SERS substrate based on an annealed thin gold (Au) film that offers multiple resonances and gap sizes within the same sample. It is not only chemically stable, but also shows reproducible trends in terms of geometry and plasmonic response. Scanning electron microscopy (SEM) reveals particle-like and island-like morphology with different gap sizes at different lateral positions of the substrate. Extinction spectra show that the plasmonic resonance of the nanoparticles/metal islands can be continuously tuned across the substrate. We observed that for the analytes 1,2-bis(4-pyridyl) ethylene (BPE) and methylene blue (MB), the maximum SERS enhancement is achieved at different lateral positions, and the shape of the extinction spectra allows for the correlation of SERS enhancement with surface morphology. Such non-uniform SERS substrates with multiple nanoparticle sizes, shapes, and interparticle distances can be used for fast screening of analytes due to the lateral variation of the resonances within the same sample. Full article
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