Special Issue "Marine Natural Product Chemistry: A Themed Issue in Honor of Professor Peter Proksch on His Research Career"
Deadline for manuscript submissions: closed (30 December 2020) | Viewed by 13111
Interests: organic and medicinal chemistry; organic synthesis; catalytic oxidative processes; marine natural products; nucleosides chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: the bioactive metabolites derived from marine organisms (sponges and corals); marine mangrove plants and their associated microorganisms
Prof. Dr. Peter Proksch is an eminent chemist of marine natural product chemistry. Throughout his career, he devoted over 20 years of his life to researching and teaching at the Heinrich Heine University in Düsseldorf, and his research interests cover marine chemical ecology, bioactive natural compounds with unique structures derived from marine macro- and micro-organisms, OSMAC and co-culture of marine-derived fungi to activate the silent biosynthetic pathways, and the mode of actions of bioactive compounds. He engaged in the field of bioactive marine natural substances, which have potential for pharmaceutical and agriculture applications. At the early stage of his research career, he focused on marine invertebrates such as sponges and corals, which are regarded to be unique sources of chemical entities with potential bioactivities that could lead to potential new drug candidates and serve as a powerful chemical defense against a multitude of natural enemies and competitors. His research group is very productive, working on numerous bioactive compounds from benthic organisms inhabiting different ocean locations. Representative works include his discovery of sponge-derived brominated isoxazoline alkaloids and amide dienon that enzymatically converted from aeroplysinin-1 in the wounded sponge showing pronounced antibiotic activity against many Gram-positive and Gram-negative marine bacteria; brominated bastadins protecting sponges from overgrowth by fouling organisms such as barnacles and mollusks; and dibromohemibastadin (DBHB) preventing fouling by barnacles or mussels through inhibition of a phenoloxidase in the marine environment. In the last few decades prior to his retirement, he explored marine-derived fungi as sources of bioactive natural products due to the fact that many bioactive compounds isolated from sponges or other marine invertebrates are in fact of microbial origins and live within multicellular hosts, and he uncovered diverse fungi-derived new natural products with potent bioactivities, such as fungus-derived chlorflavonin as a new antibacterial agent and new inhibitor of tuberculosis pathogen and multiresistant strains with a new mode of action, phomoxanthone A provoking apoptosis in various tumor cell lines including platin-resistant cells, atropisomeric dihydroanthracenones as the inhibitors of multiresistant Staphylococcus aureus, and embellicine A as a novel NF-κB inhibitor. Further, he focused on the effect of microbial cross-talk on natural product accumulation and developed a microbial co-cultivation methodology to induce cryptic natural products and on the enhancement of constitutive present metabolites compared to axenic cultures. Prof. Proksch supervised more than 80 international doctoral students and published more than 600 peer-review original publications, review articles, and book chapters.
Prof. Dr. Peter Proksch was born in Leipzig in 1953, and studied biology in Cologne, where he received his doctorate, Master, and Bachelor in 1975–1980. After a research stay for two years (1980–1982) as a postdoctoral fellow at the University of California in Irvine (USA), he got a position as an assistant professor habilitated in the field of biology and pharmaceutical biology at the University of Cologne and at the Technical University of Braunschweig in 1982–1989. He was employed as an associate professor for pharmaceutical biology at the University of Würzburg (1990–1999), and then he was promoted as a full professor and a head of the Institute for Pharmaceutical Biology and Biotechnology at Heinrich Heine University Düsseldorf (Germany) until his retirement. Prof. Peter Proksch extended broad international collaborations to help scientists, especially in Asian countries including China, Indonesia, Vietnam, India, and Nigeria. Based on his excellent contribution in the marine natural product science and the international cooperation, he was given the National Friendship Award of the PRC (China) in 2016, the Qilu Friendship Award of Shandong Province (China) in 2014, the Coconut Island Commemorative Award (China) in 2017, an Honorary Doctorate from the University of Abuja (Nigeria) in 2017, a Commemorative Medal of the Vietnamese Academy of Sciences (Vietnam) in 2008, and the First Prize Inventor Award (North-Rhine Westfalia, Germany) in 2008. He has also received an Honorary Professorship of the Three Gorges University (China) (2015) and the Chinese Academy of Tropical Agricultural Science (2016),
Molecules is very pleased to host a Special Issue in honor of Prof. Peter Proksch for his excellent research contribution, and we invite scientists to submit original contributions to “Marine Natural Product Chemistry: A Themed Issue in Honor of Professor Peter Proksch on His Research Career”.
Prof. Dr. Vincenzo Piccialli
Prof. Dr. Wenhan Lin
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